Lycopene Ameliorates Insulin Resistance and Increases Muscle Capillary Density in Aging via Activation of SIRT1

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works

Mammalian Sirtuins: Biological Insights and Disease Relevance

Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

Bock, K. D., Γεωργιάδου, Μ., Schoors, S., Kuchnio, A., Wong, B. W., Cantelmo, A. R., Quaegebeur, A., Ghesquière, B., Cauwenberghs, S., Eelen, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.037 · Cited by 1,559 · see citing works

Glucose transporters in the 21st Century

Thorens, B., & Mueckler, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00712.2009 · Cited by 1,013 · see citing works

Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview

Mariani, E., Polidori, M. C., Cherubini, A., & Mecocci, P. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.04.023 · Cited by 682 · see citing works

Release of Interleukins and Other Inflammatory Cytokines by Human Adipose Tissue Is Enhanced in Obesity and Primarily due to the Nonfat Cells

Fain, J. N. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74018-3 · Cited by 679 · see citing works

Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention

Kaulmann, A., & Bohn, T. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.07.010 · Cited by 675 · see citing works

Endothelial Cell Metabolism in Normal and Diseased Vasculature

Eelen, G., de Zeeuw, P., Simons, M., & Carmeliet, P. (2015) · Circulation Research · doi:10.1161/circresaha.116.302855 · Cited by 619 · see citing works

SIRT1 Controls Endothelial Angiogenic Functions During Vascular Growth

Potente, M., Ghaeni, L., Baldessari, D., Mostoslavsky, R., Rossig, L., Dequiedt, F., Haendeler, J., Mione, M., Dejana, E., Alt, F. W., et al. (2007) · Genes & Development · doi:10.1101/gad.435107 · Cited by 608 · see citing works

Identification of a novel gene encoding an insulin-responsive glucose transporter protein

Birnbaum, M. J. (1989) · Cell · doi:10.1016/0092-8674(89)90968-9 · Cited by 598 · see citing works

Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review

Tsamis, A., Krawiec, J. T., & Vorp, D. A. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.1004 · Cited by 509 · see citing works

Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging

Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L.-J., Osborne, B., Joshi, S., Lu, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.008 · Cited by 496 · see citing works

Traffic-Related Air Pollution and Incident Type 2 Diabetes: Results from the SALIA Cohort Study

Krämer, U., Herder, C., Sugiri, D., Straßburger, K., Schikowski, T., Ranft, U., & Rathmann, W. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901689 · Cited by 395 · see citing works

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

Vicent, D., Ilany, J., Kondo, T., Naruse, K., Fisher, S. J., Kisanuki, Y. Y., Bursell, S. E., Yanagisawa, M., King, G. L., & Kahn, C. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15211 · Cited by 355 · see citing works

Serum antioxidants and inflammation predict red cell distribution width in older women: The Women's Health and Aging Study I

Semba, R. D., Patel, K. V., Ferrucci, L., Sun, K., Roy, C. N., Guralnik, J. M., & Fried, L. P. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.03.001 · Cited by 345 · see citing works

MicroRNA-34a regulation of endothelial senescence

Ito, T., Yagi, S., & Yamakuchi, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.012 · Cited by 336 · see citing works

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production

Longchamp, A., Mirabella, T., Arduini, A., MacArthur, M. R., Das, A., Trevino-Villarreal, J. H., Hine, C., Ben‐Sahra, I., Knudsen, N. H., Brace, L. E., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.001 · Cited by 327 · see citing works

Identification of genetically and oceanographically distinct blooms of jellyfish - DUPE OF DU:30098064

Lee, P. L. M., Dawson, M. N., Neill, S. P., Robins, P., Houghton, J. D. R., Doyle, T. K., & Hays, G. C. (2013) · Journal of The Royal Society Interface · Cited by 266 · see citing works

Modulation of Vascular Smooth Muscle Signaling by Reactive Oxygen Species

Lyle, A. N., & Griendling, K. K. (2006) · Physiology · doi:10.1152/physiol.00004.2006 · Cited by 239 · see citing works

Dissecting Multiple Steps of GLUT4 Trafficking and Identifying the Sites of Insulin Action

Bai, L., Wang, Y., Fan, J., Chen, Y., Ji, W., Qu, A., Xu, P., James, D. E., & Xu, T. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.013 · Cited by 216 · see citing works

PGC-1α Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload

Lu, Z., Xu, X., Hu, X., Fassett, J., Zhu, G., Tao, Y., Li, J., Huang, Y., Zhang, P., Zhao, B., et al. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2940 · Cited by 215 · see citing works

The Physiology of Bone Blood Flow: A Review

McCarthy, I. (2006) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.f.00890 · Cited by 202 · see citing works

Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities?

Anagnostis, P. G., Karagiannis, A. I., Kakafika, A. I., Τζιόμαλος, Κ., Athyros, V. G., & Mikhailidis, D. P. (2008) · Osteoporosis International · doi:10.1007/s00198-008-0648-5 · Cited by 171 · see citing works

Vascular endothelial growth factor control mechanisms in skeletal growth and repair

Hu, K., & Olsen, B. R. (2016) · Developmental Dynamics · doi:10.1002/dvdy.24463 · Cited by 134 · see citing works

Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replicative lifespan and enhanced angiogenic capacity in a high glucose environment

Borradaile, N. M., & Pickering, J. G. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00453.x · Cited by 129 · see citing works

Endothelial cell survival and apoptosis in the tumor vasculature

Liu, W., Ahmad, S. A., Reinmuth, N., Shaheen, R. M., Jung, Y. D., Fan, F., & Ellis, L. M. (2000) · APOPTOSIS · doi:10.1023/a:1009679307513 · Cited by 128 · see citing works

Molecular mechanisms of insulin resistance in chronic kidney disease

Thomas, S. S., Zhang, L., & Mitch, W. E. (2015) · Kidney International · doi:10.1038/ki.2015.305 · Cited by 113 · see citing works

Characterization of Multiple Signaling Pathways of Insulin in the Regulation of Vascular Endothelial Growth Factor Expression in Vascular Cells and Angiogenesis

Jiang, Z. Y., He, Z., King, B. L., Kuroki, T., Opland, D. M., Suzuma, K., Suzuma, I., Ueki, K., Kulkarni, R., Kahn, C. R., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303314200 · Cited by 110 · see citing works

Antiobesity Effects and Improvement of Insulin Sensitivity by 1-Deoxynojirimycin in Animal Models

Kong, W.-H., Oh, S.-H., Ahn, Y.-R., Kim, K., Kim, J.-H., & Seo, S.-W. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073223i · Cited by 98 · see citing works

Effect of Inflammation on the Aging Microcirculation: Impact on Skeletal Muscle Blood Flow Control

Payne, G. W. (2006) · Microcirculation · doi:10.1080/10739680600618918 · Cited by 96 · see citing works

The bone marrow-derived endothelial progenitor cell response is impaired in delayed wound healing from ischemia

Bauer, S. M., Goldstein, L. J., Bauer, R. J., Chen, H., Putt, M. E., & Velazquez, O. C. (2006) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.08.038 · Cited by 85 · see citing works

Imaging Insights on the Aorta in Aging

Ohyama, Y., Redheuil, A. B., Kachenoura, N., Ambale‐Venkatesh, B., & Lima, J. A. C. (2018) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.117.005617 · Cited by 81 · see citing works

Apo-10′-Lycopenoic Acid, a Lycopene Metabolite, Increases Sirtuin 1 mRNA and Protein Levels and Decreases Hepatic Fat Accumulation in ob/ob Mice3

Chung, J., Koo, K., Lian, F., Hu, K. Q., Ernst, H., & Wang, X. (2012) · Journal of Nutrition · doi:10.3945/jn.111.150052 · Cited by 80 · see citing works

Vascular Endothelial Growth Factor A (VEGF-A) Induces Endothelial and Cancer Cell Migration through Direct Binding to Integrin α9β1

Oommen, S., Gupta, S. K., & Vlahakis, N. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.175158 · Cited by 76 · see citing works

AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation

Park, H., Lee, S., Shrestha, P., Kim, J., Park, J. A., Ko, Y., Ban, Y. H., Park, D. Y., Ha, S., Koh, G. Y., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201503113 · Cited by 72 · see citing works

Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance

Koronowski, K. B., Khoury, N., Saul, I., Loris, Z. B., Cohan, C. H., Stradecki, H. M., Dave, K. R., Young, J. I., & Pérez‐Pinzón, M. A. (2017) · Stroke · doi:10.1161/strokeaha.117.018562 · Cited by 72 · see citing works

Lycopene Improves Insulin Sensitivity through Inhibition of STAT3/Srebp-1c-Mediated Lipid Accumulation and Inflammation in Mice fed a High-Fat Diet

Zeng, Z., Wang, H., Jia, Z., & Hao, S. (2017) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-101919 · Cited by 67 · see citing works

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging

Das, A., Huang, G. X., Bonkowski, M. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.026 · Cited by 54 · see citing works

Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1

Xu, Y., Leo, M. A., & Lieber, C. S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01435-9 · Cited by 49 · see citing works

Capillary ultrastructure and mitochondrial volume density in skeletal muscle in relation to reduced exercise capacity of patients with intermittent claudication

Baum, O., Torchetti, E., Malik, C., Høier, B., Walker, M. A., Walker, P. J., Odriozola, A., Graber, F., Tschanz, S. A., Bangsbo, J., et al. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00480.2015 · Cited by 44 · see citing works

Possible mechanisms of lycopene amelioration of learning and memory impairment in rats with vascular dementia

Zhao, X., Zhu, N., Yin, X., Lin, R., Fan, X.-L., Chen, S., & Zhu, Y.-M. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.265565 · Cited by 36 · see citing works

Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity

Hughes-Large, J. M., Pang, D., Robson, D. L., Chan, P., Toma, J., & Borradaile, N. M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.10.090 · Cited by 35 · see citing works

Fractal dimensions of laser doppler flowmetry time series

Carolan‐Rees, G., Tweddel, A. C., Naka, K. Κ., et al. (2002) · Medical Engineering & Physics · doi:10.1016/s1350-4533(01)00117-5 · Cited by 29 · see citing works

Intracellular Adenosine Triphosphate Delivery Enhanced Skin Wound Healing in Rabbits

Wang, J., Zhang, Q., Wan, R., Mo, Y., Li, M., Tseng, M. T., & Chien, S. (2009) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e31817fe47e · Cited by 29 · see citing works

Effects of Red Wine and Vodka on Collateral-Dependent Perfusion and Cardiovascular Function in Hypercholesterolemic Swine

Chu, L. M., Lassaletta, A. D., Robich, M. P., Liu, Y., Burgess, T. A., Laham, R. J., Sweeney, J. D., Shen, T., & Sellke, F. W. (2012) · Circulation · doi:10.1161/circulationaha.111.082172 · Cited by 27 · see citing works

Aging Changes of the Angioarchitecture and Arterial Morphology of the Spinal Cord in Rats

Qiu, M., & Zhu, X.-H. (2004) · Gerontology · doi:10.1159/000080173 · Cited by 23 · see citing works

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice

Leon, E. R. D., Brinkman, J. A., Fenske, R. J., Gregg, T., Schmidt, B., Sherman, D. S., Richardson, N. E., Peter, D. C., Kimple, M. E., Lamming, D. W., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-36289-0 · Cited by 22 · see citing works

Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice

Nawaz, A., Mehmood, A., Kanatani, Y., Kado, T., Igarashi, Y., Takikawa, A., Yamamoto, S., Okabe, K., Nakagawa, T., Yagi, K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29773-0 · Cited by 21 · see citing works

Blood flow in the hands of a predefined homogeneous systemic sclerosis population: the presence of digital ulcers and the improvement with bosentan

Meijs, J., Voskuyl, A. E., Bloemsaat-Minekus, J. P. J., & Vonk, M. C. (2014) · Lara D. Veeken · doi:10.1093/rheumatology/keu300 · Cited by 20 · see citing works

Assessment of the elasticity properties of the ascending aorta in patients with subclinical hypothyroidism by tissue Doppler imaging

Yurtdaş, M., Gen, R., Özcan, T., & Aydın, M. K. (2013) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302013000200006 · Cited by 17 · see citing works

Bax inhibiting peptide reduces apoptosis in neonatal rat hypoxic-ischemic brain damage.

Sun, M., Cui, K.-J., Yu, M.-M., Zhang, H., Peng, X.-L., & Jiang, H. (2015) · PubMed Central · Cited by 17 · see citing works

The Effects of Hypothyroidism on the Mechanical Properties and Histomorphological Structure of the Thoracic Aorta

Moulakakis, K. G., Sokolis, D. P., Perrea, D. N., et al. (2009) · Angiology · doi:10.1177/0003319709344191 · Cited by 8 · see citing works

Oxidative Stress & FoxO Transcription Factors in Cardiovascular Aging

Kim, J., Cho, S. Y., Cho, D., et al. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666161213100140 · Cited by 6 · see citing works

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works

Endothelial cell apoptosis in angiogenesis and vessel regression

Watson, E. L., Grant, Z. L., & Coultas, L. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2577-y · Cited by 138 · see citing works

Live imaging of angiogenesis during cutaneous wound healing in adult zebrafish

Noishiki, C., Yuge, S., Ando, K., Wakayama, Y., Mochizuki, N., Ogawa, R., & Fukuhara, S. (2019) · Angiogenesis · doi:10.1007/s10456-018-09660-y · Cited by 52 · see citing works

Tumor Angiogenesis, Vascularization, and Contrast-Enhanced Magnetic Resonance Imaging

Bhujwalla, Z. M., Artemov, D., & Glockner, J. F. (1999) · Topics in Magnetic Resonance Imaging · doi:10.1097/00002142-199904000-00002 · Cited by 59 · see citing works

Angiogenesis and the skin

Barnhill, R. L., & Wolf, J. E. (1987) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(87)70161-3 · Cited by 44 · see citing works

Blood Vessel Growth in the Endometrium

Goodger, A. M., & Rogers, P. A. W. (1995) · Microcirculation · doi:10.3109/10739689509148277 · Cited by 34 · see citing works