Saliva as a diagnostic tool for oral and systemic diseases
Open accessAbstract
Early disease detection is not only vital to reduce disease severity and prevent complications, but also critical to increase success rate of therapy. Saliva has been studied extensively as a potential diagnostic tool over the last decade due to its ease and non-invasive accessibility along with its abundance of biomarkers, such as genetic material and proteins. This review will update the clinician on recent advances in salivary biomarkers to diagnose autoimmune diseases (Sjogren's syndrome, cystic fibrosis), cardiovascular diseases, diabetes, HIV, oral cancer, caries and periodontal diseases. Considering their accuracy, efficacy, ease of use and cost effectiveness, salivary diagnostic tests will be available in dental offices. It is expected that the advent of sensitive and specific salivary diagnostic tools and the establishment of defined guidelines and results following rigorous testing will allow salivary diagnostics to be used as chair-side tests for several oral and systemic diseases in the near future.
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Because saliva can be readily collected, it has been used in connection to in vitro diagnostic biosensors on strips or portable device platforms.
“Because saliva can be readily collected123-125, it has been used in connection to in vitro diagnostic biosensors on strips or portable device platforms,126-134.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [123]
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References 67 · Cited by 431
- Authors
- Javaid, M. A., Ahmed, A. S., Durand, R., & Tran, S. D.
- Affiliations
- University of British Columbia (CA)
- McGill University (CA)
- Université de Montréal (CA)
- Corresponding author
- Tran, Simon D.
- Venue
- Journal of Oral Biology and Craniofacial Research
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 6
- Issue
- 1
- Pages
- 67-76
- ISSN
- 2212-4268 (ISSN-L)
- PMC
- PMC4756071
- OpenAlex
- W1655497889
- Cited by
- 431
- References
- 67
- Citations by year
- 2026: 27 · 2025: 51 · 2024: 35 · 2023: 59 · 2022: 36 · 2021: 50 · 2020: 50 · 2019: 47 · 2018: 30 · 2017: 34 · 2016: 12
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Oral Biology and Craniofacial Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
- Keywords
- saliva, salivary biomarkers, salivary diagnostics, non-invasive diagnosis, Sjögren's syndrome, cystic fibrosis, cardiovascular disease, diabetes mellitus, HIV, oral cancer, dental caries, periodontal disease, oral diseases, systemic disease
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