Cited by 375Osteoarthritis Treatment and MechanismsPharmacological Effects of Medicinal PlantsProteoglycans and glycosaminoglycans research

The DOI matches its Crossref record; 42 of the 45 references it cites were found in a registry or an index.

Stigmasterol: a phytosterol with potential anti-osteoarthritic properties

Open access

Gabay, O., Sanchez, C., Salvat, C., Chevy, F., Breton, M., Nourissat, G., Wolf, C., Jacques, C., Berenbaum, F.·2010·Osteoarthritis and Cartilage

DOI 10.1016/j.joca.2009.08.019

Open this paper in CoChat — free account Open PDF

Abstract

Objective Although most studies have focused on the cholesterol-lowering activity of stigmasterol, other bioactivities have been ascribed to this plant sterol compound, one of which is a potential anti-inflammatory effect. To investigate the effects of stigmasterol, a plant sterol, on the inflammatory mediators and metalloproteinases produced by chondrocytes.Method We used a model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes in primary culture stimulated with or without IL-1beta (10 ng/ml), for 18 h. Cells were pre-incubated for 48 h with stigmasterol (20 microg/ml) compared to untreated cells. We initially investigated the presence of stigmasterol in chondrocyte, compared to other phytosterols. We then assessed the role of stigmasterol on the expression of various genes involved in inflammation (IL-6) and cartilage turn-over (MMP-3, -13, ADAMTS-4, -5, type II collagen, aggrecan) by quantitative Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). Additional experiments were carried out to monitor the production of MMP-3 and prostaglandin E2 (PGE(2)) by specific immuno-enzymatic assays. We eventually looked at the role of stigmasterol on NF-kappaB activation by western blot, using an anti-IkappaBalpha antibody.Results After 18 h of IL-1beta treatment, MMP-3, MMP-13, ADAMTS-4, but not ADAMTS-5 RNA expression were elevated, as well as MMP-3 and PGE(2) protein levels in mouse and human chondrocytes. Type II collagen and aggrecan mRNA levels were significatively reduced. Pre-incubation of stigmasterol to IL-1beta-treated cells significantly decreased these effects described above (significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE(2) protein in human and mouse) Finally, stigmasterol was capable of counteracting the IL-1beta-induced NF-kappaB pathway.Conclusion This study shows that stigmasterol inhibits several pro-inflammatory and matrix degradation mediators typically involved in OA-induced cartilage degradation, at least in part through the inhibition of the NF-kappaB pathway. These promising results justify further ex vivo and in vivo investigations with stigmasterol.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.joca.2009.08.019

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Nuclear factor-κB
Aggarwal, B. B. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.003 · Cited by 1,586
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
Glasson, S. S., Askew, R., Sheppard, B. J., Carito, B. A., Blanchet, T., Ma, H., Flannery, C. R., Peluso, D., Kanki, K., Yang, Z., et al. (2005) · Nature · doi:10.1038/nature03369 · Cited by 1,258
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
Loeser, R. F. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.03.002 · Cited by 726
Natural products as a gold mine for arthritis treatment
Khanna, D., Sethi, G., AHN, K., PANDEY, M., Kunnumakkara, A. B., SUNG, B., Aggarwal, A. N., & Aggarwal, B. B. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.03.002 · Cited by 391
Suppression of the Nuclear Factor‐κB Activation Pathway by Spice‐Derived Phytochemicals: Reasoning for Seasoning
Aggarwal, B. B., & Shishodia, S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.054 · Cited by 364
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation
Tortorella, M. D., Malfait, A., Deccico, C., & Arner, E. C. (2001) · Osteoarthritis and Cartilage · doi:10.1053/joca.2001.0427 · Cited by 327
Guggulsterone Inhibits NF-κB and IκBα Kinase Activation, Suppresses Expression of Anti-apoptotic Gene Products, and Enhances Apoptosis
Shishodia, S., & Aggarwal, B. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408093200 · Cited by 265
Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism
Goldring, M. B., Otero, M., Tsuchimochi, K., Ijiri, K., & Li, Y. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.098764 · Cited by 264
Toward understanding the dynamics of membrane-raft-based molecular interactions
Kusumi, A., & Suzuki, K. G. N. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.10.001 · Cited by 228

Show all 45 references

Research works printed but not linked: 2

Thiers, 1953, Rev Rhum Mal Osteoartic, 20, 636
Wlodarek, 2007, Rocz Panstw Zakl Hig, 58, 47

Sorted by citations

Items 101–200 of 374

In-Vitro Screenings for Biological and Antioxidant Activities of Water Extract from Theobroma cacao L. Pod Husk: Potential Utilization in Foods
Yahya, M., Ginting, B., & Saidi, N. (2021) · Molecules · doi:10.3390/molecules26226915 · Cited by 28
Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor
Zhang, J., Zhang, C., Li, M., Meng, Z., Gu, N., & Song, G. (2023) · Pharmaceutical Biology · doi:10.1080/13880209.2023.2173252 · Cited by 28
Free radical scavenging, α-glucosidase inhibitory and anti-inflammatory constituents from Indian sedges, Cyperus scariosus R.Br and Cyperus rotundus L.
Botlagunta, M., Kakarla, L., Katragadda, S., Tiwari, A. K., Kotamraju, K., Madhusudana, K., & Kumar, D. (2016) · Pharmacognosy Magazine · doi:10.4103/0973-1296.191467 · Cited by 28
Edible and Herbal Plants for the Prevention and Management of COVID-19
Li, S., Cheng, C., Zhang, C., Tang, G., Tan, H., Chen, H., Wang, N., Lai, A. Y. K., & Feng, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.656103 · Cited by 28
Beneficial effects of secretome derived from mesenchymal stem cells with stigmasterol to negate IL-1β-induced inflammation in-vitro using rat chondrocytes—OA management
Sampath, S. J. P., Rath, S. N., Kotikalapudi, N., & Venkatesan, V. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00874-z · Cited by 27
Phytochemical analysis and in vitro anthelmintic activity of Imperata cylindrica underground parts
Lalthanpuii, P. B., & Lalchhandama, K. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-03125-w · Cited by 27
Anti-Inflammatory Activities of Yataprasen Thai Traditional Formulary and Its Active Compounds, Beta-Amyrin and Stigmasterol, in RAW264.7 and THP-1 Cells
Angsusing, J., Singh, S. K., Samee, W., Tadtong, S., Stokes, L., O'Connell, M. A., Bielecka, H., Toolmal, N., Mangmool, S., & Chittasupho, C. (2024) · Pharmaceuticals · doi:10.3390/ph17081018 · Cited by 27
Minor Constituents and Phytochemicals of the Kernel
Acosta‐Estrada, B. A., Gutierrez-Uribe, J. A., & Serna-Saldivar, S. O. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811971-6.00014-0 · Cited by 26
Gas chromatography–mass spectrometry profile of four Calendula L. taxa: A comparative analysis
Faustino, M. V., Seca, A. M. L., da Silveira, P. C., Silva, A. M. S., & Pinto, D. C. G. A. (2017) · Industrial Crops and Products · doi:10.1016/j.indcrop.2017.04.029 · Cited by 26
GC-MS analysis of Phytocomponents in the Methanol Extract of Premna latifolia Roxb
Kumar, R., Kumar, B., Kumar, A., Kumar, A., & Singh, M. (2021) · Pharmacognosy Research · doi:10.5530/pres.14.1.4 · Cited by 25
Potential metabolites of Arecaceae family for the natural anti-osteoarthritis medicine: A review
Sartinah, A., Nugrahani, I., Ibrahim, S., & Anggadiredja, K. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e12039 · Cited by 28
SECONDARY METABOLITES FOUND IN BERGENIA SPECIES: A COMPENDIOUS REVIEW
Chauhan, R., & Dwivedi, J. (2013) · Cited by 25
Tryptophan and Sterols from Salvia limbata
Saeidnia, S., Gohari, A. R., Malmir, M., Afrapoli, F. M., & Ajani, Y. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 25
Development and Characterization of Phytosterol-Enriched Oil Microcapsules for Foodstuff Application
Tolve, R., Condelli, N., Can, A., & Tchuenbou-Magaia, F. L. (2017) · Food and Bioprocess Technology · doi:10.1007/s11947-017-1990-4 · Cited by 25
In Vitro and In Vivo Evaluation for Antioxidant and Anti-Diabetic Properties of Cyperus rotundus L. Kombucha
Dechakhamphu, A., Wongchum, N., Chumroenphat, T., Tanomtong, A., Pinlaor, S., & Siriamornpun, S. (2023) · Foods · doi:10.3390/foods12224059 · Cited by 24
Engineering of Phytosterol-Producing Yeast Platforms for Functional Reconstitution of Downstream Biosynthetic Pathways
Xu, S., Chen, C., & Li, Y. (2020) · ACS Synthetic Biology · doi:10.1021/acssynbio.0c00417 · Cited by 24
STITCH, Physicochemical, ADMET, and In Silico Analysis of Selected Mikania Constituents as Anti-Inflammatory Agents
Narayanaswamy, R., Vasantha‐Srinivasan, P., Wadaan, M. A., Baabbad, A., Vinayagam, R., & Kang, S. G. (2023) · Processes · doi:10.3390/pr11061722 · Cited by 24
Anti-Inflammatory and Antioxidant Activities of Lipophilic Fraction from Liriope platyphylla Seeds Using Network Pharmacology, Molecular Docking, and In Vitro Experiments
Truong, V., Bae, Y.-J., Rarison, R. H. G., Bang, J.-H., Park, S.-Y., & Jeong, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914958 · Cited by 24
Oleochemical Properties for Different Fractions of Foxtail Millet Bran
Ji, J., Liu, Y., Ge, Z., Zhang, Y., & Wang, X. (2019) · Journal of Oleo Science · doi:10.5650/jos.ess19063 · Cited by 23
GC-MS Analysis of Bioactive Phytochemicals in Methanol Extract of Aerial Part and Callus of Dipterygium glaucum Decne
Choudhary Choudhary, D., Shekhawat Shekhawat, J. K., & Kataria, V. (2019) · Pharmacognosy Journal · doi:10.5530/pj.2019.11.165 · Cited by 23
Solanum paniculatum L. decreases levels of inflammatory cytokines by reducing NFKB, TBET and GATA3 gene expression in vitro
Rios, R., Silva, H. B. F., Carneiro, N. V. Q., Pires, A. D. O., Carneiro, T. C. B., Costa, R. D. S., Marques, C. R., Machado, M. S. S., Velozo, E. D. S., da Silva, T. M. G., et al. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.07.014 · Cited by 23
A dietary antioxidant supplementation of Jamaican cherries (Muntingia calabura L.) attenuates inflammatory related disorders
Gomathi, R., Anusuya, N., & Manian, S. (2013) · Food Science and Biotechnology · doi:10.1007/s10068-013-0146-1 · Cited by 22
Inhibitory Effects of Chloroform Extracts Derived from Corbicula fluminea on the Release of Pro-inflammatory Cytokines
Lin, C.-M., Lin, Y., Tsai, N., Wu, H.-Y., Ho, S.-Y., Chen, C., Liu, Y.-K., Chiu, Y., Ho, L.-P., Lee, R.-P., et al. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2051202 · Cited by 23
Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways
Yuan, H., Wu, X., Wang, X., & Yuan, C. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.06.001 · Cited by 21
A novel therapeutic combination of mesenchymal stem cells and stigmasterol to attenuate osteoarthritis in rodent model system— a proof of concept study
Sampath, S. J. P., Kotikalapudi, N., & Venkatesan, V. (2021) · Stem Cell Investigation · doi:10.21037/sci-2020-048 · Cited by 21
Mechanistic Insights into the Neuroprotective Potential of Sacred Ficus Trees
Shim, K. H., Sharma, N., & An, S. S. A. (2022) · Nutrients · doi:10.3390/nu14224731 · Cited by 26
Advances in Ayurvedic medicinal plants and nanocarriers for arthritis treatment and management: A review
Venugopal, E., Krishnan, K., Bhattacharyya, A., & Selvakumar, R. (2020) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2020.100412 · Cited by 23
Phytochemical Analysis of Acaciaehrenbergiana (Hayne) Grown in Qatar: Identification of Active Ingredients and Their Biological Activities
Thotathil, V., Rizk, H. H., Fakrooh, A., & Sreerama, L. (2022) · Molecules · doi:10.3390/molecules27196400 · Cited by 20
Phytosterol of lotus seed core powder alleviates hypercholesterolemia by regulating gut microbiota in high-cholesterol diet-induced C57BL/6J mice
Liu, D., Pi, J., Zhang, B., Zeng, H., Li, C., Xiao, Z., Fang, F., Liu, M., Deng, N., & Wang, J. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.102279 · Cited by 22
Cloning, characterization, and heterologous expression of a novel glucosyltransferase gene from sophorolipid-producing Candida bombicola
Solaiman, D. K. Y., Liu, Y., Moreau, R. A., & Zerkowski, J. A. (2014) · Gene · doi:10.1016/j.gene.2014.02.029 · Cited by 20
The role of fluconazole in the regulation of fatty acid and unsaponifiable matter biosynthesis in Schizochytrium sp. MYA 1381
Li, J., Zhou, H., Pan, X., Li, Z., Lu, Y., He, N., Meng, T., Yao, C., Chen, C., & Ling, X. (2019) · BMC Microbiology · doi:10.1186/s12866-019-1622-4 · Cited by 21
Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Effects of Leptopus Cordifolius Decne. In Diabetic Mice
Rahman, S., Jan, G., Jan, F. G., & Rahim, H. U. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.643242 · Cited by 20
SBT (Composed of Panax ginseng and Aconitum carmichaeli) and Stigmasterol Enhances Nitric Oxide Production and Exerts Curative Properties as a Potential Anti-Oxidant and Immunity-Enhancing Agent
Han, N., Kim, K. C., Kim, J., Park, H., Ko, S., & Moon, P. (2022) · Antioxidants · doi:10.3390/antiox11020199 · Cited by 19
In vitro cytotoxic effect of stigmasterol derivatives against breast cancer cells
Dube, N. P., Tembu, V. J., Nyemba, G. R., Davison, C., Rakodi, G. H., Kemboi, D., de la Mare, J., Siwe‐Noundou, X., & Manicum, A.-L. E. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04137-y · Cited by 19
Chondroitin Sulfate/Hyaluronic Acid-Blended Hydrogels Suppress Chondrocyte Inflammation under Pro-Inflammatory Conditions
Nguyen, M. B., Battistoni, C. M., Babiak, P. M., Liu, J. C., & Panitch, A. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00200 · Cited by 19
Featured Article: Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo- induced murine osteoarthritis
Monfoulet, L., Philippe, C., Mercier, S., Coxam, V., & Wittrant, Y. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370214565078 · Cited by 21
Oleanane and Stigmasterol-Type Triterpenoid Derivatives from the Stem Bark of Albizia gummifera and Their Antibacterial Activities
Ayele, T. T., GURMESSA, G. T., Abdissa, Z., Kenasa, G., & Abdissa, N. (2022) · Journal of Chemistry · doi:10.1155/2022/9003143 · Cited by 19
Rapeseed meal nutraceuticals
Hashmi, S. I., Satwadhar, P. N., Khotpal, R. R., Deshpande, H. W., Ka, S., & Vibhute, R. P. (2010) · Journal of Oilseed Brassica · Cited by 19
Chemical profile and antibacterial activity of acetone extract of Homalomena cochinchinensis Engl. (Araceae)
Van, H. T., Tam, L. N., Nguyen, D. L., Tran, G., Huynh, N. T. A., Vo, H. S., Chu, V. H., Truong, H. A. V., & Nguyen, Q. H. (2021) · Plant Science Today · doi:10.14719/pst.2021.8.1.971 · Cited by 18
Pectin–zein based stigmasterol nanodispersions ameliorate dextran sulfate sodium-induced colitis in mice
Feng, S., Sui, M., Wang, D., Ritzoulis, C., Farag, M. A., & Shao, P. (2021) · Food & Function · doi:10.1039/d1fo02493k · Cited by 18
Unravelling the anti-inflammatory mechanism of Allium cepa: an integration of network pharmacology and molecular docking approaches
Omoboyede, V., Onile, O. S., Oyeyemi, B. F., Aruleba, R. T., Fadahunsi, A., Oke, G. A., Onile, T. A., Ibrahim, O., & Adekiya, T. A. (2023) · Molecular Diversity · doi:10.1007/s11030-023-10614-w · Cited by 18
Network pharmacology and molecular docking approach to investigate the mechanism of a Chinese herbal formulation Yougui pills against steroid-related osteonecrosis of the femoral head
Wang, Y., Xu, T., Chen, X., Yang, Y., Liu, L., Wang, Y., & Zhang, P. (2024) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2024.105609 · Cited by 18
Bioassay Guided Isolation and Identification of Anti-inflammatory Active Compounds from the Root of Ficus formosana
Huang, G., Deng, J., Huang, S., Wang, S., Chang, Y., & Kuo, Y. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4033766 · Cited by 18
Validation of phytosterol analysis by alkaline hydrolysis and trimethylsilyl derivatization coupled with gas chromatography for rice products
Islam, M. A., Jeong, B.-G., KERR, W. L., & Chun, J. (2021) · Journal of Cereal Science · doi:10.1016/j.jcs.2021.103305 · Cited by 17
Valorization of water hyacinth through supercritical CO2 extraction of stigmasterol
de Melo, M. M. R., Silva, R. P., Silvestre, A. J. D., & Silva, C. M. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.11.036 · Cited by 17
Buddleja thyrsoidesLam. crude extract presents antinociceptive effect on an arthritic pain model in mice
Fialho, M. F. P., Brusco, I., Brum, E. D. S., Piana, M., Boligon, A. A., Trevisan, G., & Oliveira, S. M. (2017) · Biochemical Journal · doi:10.1042/bcj20170008 · Cited by 17
Elucidation of the Mechanisms and Molecular Targets of Sanhuang Xiexin Decoction for Type 2 Diabetes Mellitus Based on Network Pharmacology
Xu, M., Li, Z., Yang, L., Zhai, W., Wei, N., Zhang, Q., Chao, B., Huang, S., & Cui, H. (2020) · BioMed Research International · doi:10.1155/2020/5848497 · Cited by 17
Chemical Profiling and In Vitro Antiurolithiatic Activity of Pleurolobus gangeticus (L.) J. St.- Hil. ex H. Ohashi & K. Ohashi Along with Its Antioxidant and Antibacterial Properties
Mohan, P. K., Krishna, T. P. A., Thirumurugan, A., Kumar, T. S., & Kumari, B. D. R. (2022) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-022-04017-0 · Cited by 18
The Multicomponent Medication Lymphomyosot Improves the Outcome of Experimental Lymphedema
Keim, A., Slis, J. R., Mendez, U., Stroup, E. M., Burmeister, Y., Tsolaki, N., Gailing, O., & Goldman, J. (2013) · Lymphatic Research and Biology · doi:10.1089/lrb.2012.0024 · Cited by 17
Oldenlandia diffusa Ameliorates Dextran Sulphate Sodium-Induced Colitis Through Inhibition of NF-κB Activation
Kim, S., Kim, Y.-G., Kim, D., Jeon, Y., Kim, M.-C., Kim, H.-L., Kim, S.-Y., Jang, H.-J., Lee, B.-C., Hong, S., et al. (2011) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x11009330 · Cited by 16
Phytochemical Investigation and Therapeutical Potential of Cotinus coggygria Scop. in Alloxan‐Induced Diabetic Mice
Rahman, S., Jan, G., Jan, F. G., & Rahim, H. U. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8802178 · Cited by 17
Discovery and identification of proangiogenic chemical markers from Gastrodiae Rhizoma based on zebrafish model and metabolomics approach
Liu, M., Zhao, L., Han, L., Li, H., Shi, Y., Cui, J., Wang, C., Xu, L., & Zhong, L. (2020) · Phytochemical Analysis · doi:10.1002/pca.2949 · Cited by 15
Isolation and characterization of steroids from Calligonum polygonoides
Samejo, M. Q., Memon, S., Bhanger, M. I., & Khan, K. M. (2013) · Journal of Pharmacy Research · doi:10.1016/j.jopr.2013.03.017 · Cited by 15
Methanol extract of Guettarda speciosa Linn. inhibits the production of inflammatory mediators through the inactivation of Syk and JNK in macrophages
Le, H. T. T., Cho, Y., & Cho, S. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3377 · Cited by 15
Solvent extraction, spectral analysis and antibacterial activity of the bioactive crystals of Sargassum aquifolium (Turner) C.Agardh from Red Sea
Moni, S. S., Alam, M. F., Makeen, H. A., Alhazmi, H. A., Sultan, M. H., Siddiqui, R., Jabeen, A., Sanobar, S., Alam, M. S., Rehman, Z. U., et al. (2019) · Natural Product Research · doi:10.1080/14786419.2019.1645659 · Cited by 15
Molecular docking of secondary metabolites from Indonesian marine and terrestrial organisms targeting SARS-CoV-2 ACE-2, M pro, and PL pro receptors
Syahputra, G., Gustini, N., Bustanussalam, B., Hapsari, Y., Sari, M., Ardiansyah, A., Bayu, A., & Putra, M. Y. (2021) · Pharmacia · doi:10.3897/pharmacia.68.e68432 · Cited by 14
A Short Review: Bioactivity of Fermented Rice Bran
Ardiansyah, A. (2021) · Journal of Oleo Science · doi:10.5650/jos.ess21190 · Cited by 14
Properties and metabolite profiling of Bambara groundnut flour as affected by different food processing conditions
Oladimeji, B. M., & Adebo, O. A. (2024) · Applied Food Research · doi:10.1016/j.afres.2024.100389 · Cited by 14
Intra-articular injection of stigmasterol-loaded nanoparticles reduce pain and inhibit the inflammation and joint destruction in osteoarthritis rat model: A pilot study
Lim, J. H., Kim, S. E., Kim, H. J., Song, G. G., & Jung, J. H. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01501-w · Cited by 14
Validation of the Key Active Ingredients and Anti-Inflammatory and Analgesic Effects of Shenjin Huoxue Mixture Against Osteoarthritis by Integrating Network Pharmacology Approach and Thin-Layer Chromatography Analysis
Yu, M., Ma, X., Song, X., Huang, Y., Jiang, H., Wang, J., & Yang, W. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s243951 · Cited by 14
HPTLC detection of altitudinal variation of the potential antivenin stigmasterol in different populations of the tropical ethnic antidote Rauvolfia serpentina
Dey, A., & Pandey, D. K. (2014) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(14)60287-x · Cited by 14
Egyptian red sea seagrass as a source of biologically active secondary metabolites
Mettwally, W. S. A., Hamdy, A.-H., El-fiky, N. M., El-Beih, A., & Mohammed, M. D. (2020) · Egyptian Pharmaceutical Journal · doi:10.4103/epj.epj_57_19 · Cited by 13
From waste to therapeutics: Extraction methodologies and biological properties of bioactive compounds from fruit and vegetable waste
Roy, P., & Graceffa, V. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105389 · Cited by 14
Agro-industrial waste seeds from Peruvian Pouteria lucuma as new source of phytosterols
Guerrero-Castillo, P., Reyes, S., de la Cruz, O. A., Sepúlveda, B., & Areche, C. (2021) · LWT · doi:10.1016/j.lwt.2021.111259 · Cited by 13
Analysis of sterol compounds from Sambucus ebulus
Bubulică, M.-V., Chirigiu, L., Popescu, M., Simionescu, A., Anoaica, P. G., & Popescu, A. (2012) · Chemistry of Natural Compounds · doi:10.1007/s10600-012-0297-y · Cited by 13
Estimation of phytochemical, nutritional, antioxidant and antibacterial activity of dried fruit of sacred figs (Ficus religiosa) and formulation of value added product (Hard Candy)
Verma, I., & Gupta, R. K. (2015) · Journal of Pharmacognosy and Phytochemistry · Cited by 13
Active Cousinia thomsonii Extracts Modulate Expression of Crucial Proinflammatory Mediators/Cytokines and NFκB Cascade in Lipopolysaccharide-Induced Albino Wistar Rat Model
Dar, K. B., Khan, I. S., Amin, S., Ganie, A. H., Bhat, A. H., Dar, S. A., Reshi, B. A., & Ganie, S. A. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s272539 · Cited by 13
A New Insight into Application for Barley Chromosome Addition Lines of Common Wheat: Achievement of Stigmasterol Accumulation
Tang, J., Ohyama, K., Kawaura, K., Hashinokuchi, H., Kamiya, Y., Suzuki, M., Muranaka, T., & Ogihara, Y. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.183533 · Cited by 13
CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC ANALYSIS OF BIOACTIVE COMPOUNDS FROM CAYRATIA TRIFOLIA (L.) STEM
Sowmya, S., Palanisamy, C. P., & Gopalakrishnan, V. K. (2016) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 13
Effect of Distigmasterol-Modified Acylglycerols on the Fluidity and Phase Transition of Lipid Model Membranes
Pruchnik, H., Włoch, A., Gładkowski, W., Grudniewska, A., Chojnacka, A., Krzemiński, M., & Rudzińska, M. (2022) · Membranes · doi:10.3390/membranes12111054 · Cited by 12
Mild and Efficient Preparation of Phytosteryl Amino Acid Ester Hydrochlorides and Their Emulsifying Properties
Jia, C., Xia, X., Liu, P., Wang, H., Zhang, J., & Zhang, X. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b07153 · Cited by 12
Bark Constituents from Mushroom-detoxifiedRhus vernicifluaSuppress Kainic Acid-induced Neuronal Cell Death in Mouse Hippocampus
Byun, J.-S., Han, Y. H., Hong, S. J., Hwang, S. M., Kwon, Y.-S., Lee, H. J., Kim, S., Kim, M. J., & Chun, W. (2010) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2010.14.5.279 · Cited by 14
Analysis of Bioactive Components of Ethanolic Extract of Coriandrum Sativum L.
Kanimozhi, D., & Bai, V. R. (2012) · Cited by 12
Integrated Analysis of Transcriptome and Metabolome in Cirsium japonicum Fisch ex DC
Park, Y. J., Baek, S., Kim, J. K., & Park, S. U. (2020) · ACS Omega · doi:10.1021/acsomega.0c04001 · Cited by 11
Antioxidant Potential of Red Palm-Pressed Mesocarp Olein
Teh, S. S., Mah, S. H., Lau, H. L. N., Teng, K., & Loganathan, R. (2021) · Journal of Oleo Science · doi:10.5650/jos.ess21147 · Cited by 11
The Bioavailability Prediction and Screening Phytochemicals of Sansevieria Trifasciata Leaves Extract
Oomariyah, N., & van Dijk, G. (2022) · MATEC Web of Conferences · doi:10.1051/matecconf/202237202003 · Cited by 11
Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example
Sun, L., Wang, D., Xu, Y., Qi, W., & Wang, Y. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/8873371 · Cited by 11
Spectral Analysis and Antiulcer Potential of Lactuca sativa through the Amelioration of Proinflammatory Cytokines and Apoptosis Markers
Syed, R. U., Moni, S. S., Lila, A. S. A., Abdallah, M. H., Abouzied, A. S., Banu, H., Alreshidi, K. S. M., Alrashidi, B. M. W., Hadi, M. A., El‐Horany, H. E., et al. (2022) · Life · doi:10.3390/life12101641 · Cited by 11
Gas chromatography-mass spectroscopic (GC-MS) analysis of n-Hexane extract of Lentinus tuber-regium (Fr) Fr (Polyporaceae) syn Pleurotus tuber regium Fr sclerotia
Afieroho, O. E., & Ugoeze, K. C. (2014) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v13i11.20 · Cited by 11
Antihypertensive activity and vascular reactivity mechanisms of Vitex pubescens leaf extracts in spontaneously hypertensive rats
Al-Akwaa, A. A., Asmawi, M. Z., Dewa, A., & Mahmud, R. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04588 · Cited by 11
Isolation and Characterization of Stigmasterol from Fritillaria roylei
Kaur, G., Gupta, V., Singhal, R., & Bansal, P. (2020) · Biology Medicine & Natural Product Chemistry · doi:10.14421/biomedich.2020.92.77-80 · Cited by 11
Investigation on the mechanisms of guiqi huoxue capsule for treating cervical spondylosis based on network pharmacology and molecular docking
Liu, Y., Zhang, J., Liu, X., Zhou, W., Stalin, A., Fu, C., Wu, J., Cheng, G., Guo, S., Jia, S., et al. (2021) · Medicine · doi:10.1097/md.0000000000026643 · Cited by 11
Ethnopharmacology and Antioxidant Activity Studies of Woody Liana Original Wallacea
Hapid, A., Napitupulu, M., & Zubair, M. S. (2021) · International Journal of Design & Nature and Ecodynamics · doi:10.18280/ijdne.160503 · Cited by 11
Characterization of Schinziophyton rautanenii (Manketti) nut oil from Namibia rich in conjugated fatty acids and tocopherol
Cheikhyoussef, N., Kandawa‐Schulz, M., Bock, R. D., de Koning, C. B., Cheikhyoussef, A., & Hussein, A. A. (2017) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2017.12.015 · Cited by 11
Stigmasterol Exerts an Anti-Melanoma Property through Down-Regulation of Reactive Oxygen Species and Programmed Cell Death Ligand 1 in Melanoma Cells
Han, N.-R., Park, H.-J., Ko, S.-G., & Moon, P. (2024) · Antioxidants · doi:10.3390/antiox13030380 · Cited by 11
Ethnomedicinal Usage, Phytochemistry and Pharmacological Potential of Solanum surattense Burm. f.
Hasan, K., Sabiha, S., Islam, N., Pinto, J. F., & Silva, O. M. D. (2024) · Pharmaceuticals · doi:10.3390/ph17070948 · Cited by 10
Phytonutrient content and oil quality of selected edible oils upon twelve months storage
Teh, S. S., & Lau, H. L. N. (2023) · Journal of the American Oil Chemists Society · doi:10.1002/aocs.12692 · Cited by 10
Nickel-Catalyzed Reductive Cross-Coupling of Propargylic Acetates with Chloro(vinyl)silanes: Access to Silylallenes
Xu, C., Xiong, Z., Qin, J., Xu, X., & Li, J. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.3c02228 · Cited by 10
Screening of some lesser known tree-borne oilseed plants from North-East India for their oil content and major fatty acid components
Chaliha, B., Lahkar, L., Doley, A., Kotoky, R., Saikia, S. P., & Nath, S. C. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.08.014 · Cited by 10
Cytotoxic metabolites from Thysanolaena maxima Roxb. available in Bangladesh
Hoque, N., Sohrab, M. H., Afroz, F., Rony, S. R., Sharmin, S., Moni, F., Hasan, C. M., & Rana, M. S. (2020) · Clinical Phytoscience · doi:10.1186/s40816-020-00226-4 · Cited by 10
A Stigmasterol Containing n-hexane Fraction ofRauvolfia serpentinaMethanolic Extract Shows Tissue-Specific Variation of Biocidal and Antioxidant Activities
Dey, A., Mukherjee, S., De, A., & Pandey, D. K. (2016) · Journal of Herbs Spices & Medicinal Plants · doi:10.1080/10496475.2015.1042617 · Cited by 10
Determination of phytocomponents and validation of squalene in ethanolic extract of Clerodendrum serratum Linn roots—using gas chromatography-mass spectroscopy and GC-FID technique
Reddy, K., Gurupadayya, B., Choezom, L., & R, H. V. P. (2021) · Journal of Analytical Science & Technology · doi:10.1186/s40543-021-00286-2 · Cited by 10
Use of Natural Components Derived from Oil Seed Plants for Treatment of Inflammatory Skin Diseases
Styrczewska, M., Żuk, M., Boba, A., Zalewski, I., & Kulma, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190716111700 · Cited by 9
Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities
Antão, A. M. R., Bangay, G., Domínguez-Martín, E. M., Dı́az-Lanza, A. M., & Rijo, P. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.768268 · Cited by 9
Valorization of food waste biomass and biomaterials from a circular economy approach
Echave, J., Fraga‐Corral, M., Pereira, A. G., Soria-López, A., Barral, M. T., Chamorro, F., Cao, H., Xiao, J., Simal‐Gándara, J., & Prieto, M. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90885-6.00004-1 · Cited by 11
Eichhornia crassipes Ameliorated Rheumatoid Arthritis by Modulating Inflammatory Cytokines and Metalloproteinase Enzymes in a Rat Model
Sattar, S., Shabbir, A., Shahzad, M., Akhtar, T., Ahmad, A., Alnasser, S. M., Riaz, B., Karimulla, S., & Ahmad, A. (2023) · Medicina · doi:10.3390/medicina59091594 · Cited by 9
Plant Sterols and Stanols for Pediatric Patients with Increased Cardiovascular Risk
Pederiva, C., Biasucci, G., Banderali, G., & Capra, M. E. (2024) · Children · doi:10.3390/children11010129 · Cited by 9
Flax Terpenoid Pathway as a Source of Health Promoting Compounds
Styrczewska, M., Kulma, A., Kostyń, K., Hasiewicz-Derkacz, K., & Szopa, J. (2013) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955713804999829 · Cited by 9
DETERMINATION OF BIOACTIVE COMPONENTS OF CARALLUMA UMBELLATA HAW. (APOCYNACEAE) BY GAS CHROMATOGRAPHY AND MASS SPECTROSCOPY ANALYSIS
Michael Evanjaline, R., & Vr, M. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i5.23103 · Cited by 9
Estudios etnofarmacológicos de Cecropia obtusifolia (Urticaceae) y su importancia en el tratamiento de la diabetes mellitus tipo 2 (DM-2): una mini-revisión
Cadena-Zamudio, J. D., Nicasio-Torres, P., Guerrero‐Analco, J. A., & Ibarra‐Laclette, E. (2018) · Acta Botanica Mexicana · doi:10.21829/abm126.2019.1361 · Cited by 9

Authors: Gabay, O., Sanchez, C., Salvat, C., Chevy, F., Breton, M., Nourissat, G., Wolf, C., Jacques, C., & Berenbaum, F.
Affiliations: Université Pierre-et-Marie-Curie (FR)
University of Liège (BE)
Inserm (FR)
Hôpital Saint-Antoine (FR)
Assistance Publique – Hôpitaux de Paris (FR)
Corresponding author: Berenbaum, F.
ORCID: Gabay, O.
Sanchez, C.
Nourissat, G.
Jacques, C.
Berenbaum, F.
Venue: Osteoarthritis and Cartilage
Publisher: Elsevier BV
Published: 2010-01
Volume: 18
Issue: 1
Pages: 106-116
ISSN: 1063-4584 (ISSN-L)
DOI: 10.1016/j.joca.2009.08.019
OpenAlex: W2070570765
Cited by: 375
References: 45
Citations by year: 2026: 19 · 2025: 12 · 2024: 34 · 2023: 35 · 2022: 40 · 2021: 39 · 2020: 30 · 2019: 26 · 2018: 17 · 2017: 26 · 2016: 20 · 2015: 12 · 2014: 15 · 2013: 17 · 2012: 12
FWCI: 7.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1508 d)
Locations: Osteoarthritis and Cartilage (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
ORBi (University of Liège) (submittedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Pharmacological Effects of Medicinal Plants
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords: stigmasterol, phytosterols, osteoarthritis, chondrocytes, IL-1β, NF-κB signaling, matrix metalloproteinases, MMP-3, MMP-13, ADAMTS-4, ADAMTS5, prostaglandin E2, type II collagen, aggrecan, cartilage degeneration, anti-inflammatory activity
MeSH terms: ADAMTS5 Protein, Aged, Aged, 80 and over, Animals, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Humans, L-Lactate Dehydrogenase, Middle Aged, RNA, Messenger, Stigmasterol, Blotting, Western, Dinoprostone, NF-kappa B, Cell Death, Matrix Metalloproteinase 3, Chondrocytes, Reverse Transcriptase Polymerase Chain Reaction, Osteoarthritis, Knee, Models, Animal, Mice, ADAM Proteins, Matrix Metalloproteinase 13, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Stigmasterol: a phytosterol with potential anti-osteoarthritic properties

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks