Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

Loeser, R.F.

doi:10.1016/j.joca.2009.03.002

Cited by 727Osteoarthritis Treatment and MechanismsTelomeres, Telomerase, and SenescenceProteoglycans and glycosaminoglycans research

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

Open access

Loeser, R.F.·2009·Osteoarthritis and Cartilage

DOI 10.1016/j.joca.2009.03.002PMC PMC2713363

Open this paper in CoChat — free account

Abstract

Objective Age-related changes in multiple components of the musculoskeletal system may contribute to the well established link between aging and osteoarthritis (OA). This review focused on potential mechanisms by which age-related changes in the articular cartilage could contribute to the development of OA.Methods The peer-reviewed literature published prior to February 2009 in the PubMed database was searched using pre-defined search criteria. Articles, selected for their relevance to aging and articular chondrocytes or cartilage, were summarized.Results Articular chondrocytes exhibit an age-related decline in proliferative and synthetic capacity while maintaining the ability to produce pro-inflammatory mediators and matrix degrading enzymes. These findings are characteristic of the senescent secretory phenotype and are most likely a consequence of extrinsic stress-induced senescence driven by oxidative stress rather than intrinsic replicative senescence. Extracellular matrix changes with aging also contribute to the propensity to develop OA and include the accumulation of proteins modified by non-enzymatic glycation.Conclusion The effects of aging on chondrocytes and their matrix result in a tissue that is less able to maintain homeostasis when stressed, resulting in breakdown and loss of the articular cartilage, a hallmark of OA. A better understanding of the basic mechanisms underlying senescence and how the process may be modified could provide novel ways to slow the development of OA.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.joca.2009.03.002

Cites

125 of 125 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Age-related decline in proliferative and synthetic capacities of articular chondrocytes may reduce subsequent tissue regeneration.
“the age-related decline in the proliferative and synthetic capacities of articular chondrocytes may reduce subsequent tissue regeneration33.”
From Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment (2017) · cites this paper as [33]
UBX0101 can clear senescent cells from aged articular cartilage, but age-related decline in proliferative and synthetic capacities of articular chondrocytes may reduce subsequent tissue regeneration.
“These findings suggest that UBX0101 can clear SnCs from aged articular cartilage, but the age-related decline in the proliferative and synthetic capacities of articular chondrocytes may reduce subsequent tissue regeneration33.”
From Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment (2017) · cites this paper as [33]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · see citing works
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · see citing works
Extension of murine life span by overexpression of catalase targeted to mitochondria
Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724 · see citing works
"A Controlled Study"
Davis, H. S. (1966) · JAMA · doi:10.1001/jama.1966.03100200106038 · Cited by 1,719 · see citing works
The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis
Sharma, L. (2001) · JAMA · doi:10.1001/jama.286.2.188 · Cited by 1,572 · see citing works
The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse
Glasson, S. S., Blanchet, T., & Morris, E. A. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.03.006 · Cited by 1,524 · see citing works
Oxidant signals and oxidative stress
Finkel, T. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00002-4 · Cited by 1,393 · see citing works
Osteoarthritis
Goldring, M. B., & Goldring, S. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21258 · Cited by 1,179 · see citing works
Redox Regulation of Cellular Signalling
Kamata, H., & Hirata, H. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(98)00037-0 · Cited by 1,150 · see citing works
A Framework for the in Vivo Pathomechanics of Osteoarthritis at the Knee
Andriacchi, T. P., Mündermann, A., Smith, R. L., Alexander, E. J., Dyrby, C. O., & Koo, S. (2004) · Annals of Biomedical Engineering · doi:10.1023/b:abme.0000017541.82498.37 · Cited by 1,068 · see citing works
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.
Billinghurst, R. C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C. H., Mitchell, P. G., Hambor, J., Diekmann, O., Tschesche, H., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119316 · Cited by 970 · see citing works
Effect of Collagen Turnover on the Accumulation of Advanced Glycation End Products
Verzijl, N., DeGroot, J., Thorpe, S. R., Bank, R. A., Shaw, J., Lyons, T. J., Bijlsma, J. W. J., Lafeber, F. P. J. G., Baynes, J., & TeKoppele, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006700200 · Cited by 964 · see citing works
Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.
Mitchell, P. G., Magna, H. A., Reeves, L. M., Lopresti‐Morrow, L., Yocum, S. A., Rosner, P. J., Geoghegan, K. F., & Hambor, J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118475 · Cited by 943 · see citing works
Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M., & Green, M. R. (2008) · Cell · doi:10.1016/j.cell.2007.12.032 · Cited by 903 · see citing works
Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94.
Dillon, C. F., Rasch, E. K., Gu, Q., & Hirsch, R. (2006) · PubMed · Cited by 815 · see citing works
Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age
Roos, H. P., Adalberth, T., Dahlberg, L., & Lohmander, S. L. (1995) · Osteoarthritis and Cartilage · doi:10.1016/s1063-4584(05)80017-2 · Cited by 540 · see citing works
Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes
Lo, Y. Y. C., & Cruz, T. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.11727 · Cited by 530 · see citing works
Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence
Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S.-I., Tahara, H., Nakayama, K., Nakayama, K. I., Ide, T., Saya, H., & Hara, E. (2006) · Nature Cell Biology · doi:10.1038/ncb1491 · Cited by 528 · see citing works
Methods to Detect Biomarkers of Cellular Senescence
Itahana, K., Campisi, J., & Dimri, G. P. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-361-5_3 · Cited by 520 · see citing works
Prevalence of Disabilities and Associated Health Conditions Among Adults—United States, 1999
(2001) · JAMA · doi:10.1001/jama.285.12.1571-jwr0328-3-1 · Cited by 495 · see citing works
Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.
Hollander, A. P., Pidoux, I., Reiner, A., Rorabeck, C. H., Bourne, R., & Poole, A. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118357 · Cited by 485 · see citing works
Impact of aging on DNA methylation
Richardson, B. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00010-2 · Cited by 420 · see citing works
Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function
Yudoh, K., van Trieu, N., Nakamura, H., Masuko, K., Kato, T., & Nishioka, K. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1499 · Cited by 397 · see citing works
The role of chondrocyte senescence in osteoarthritis
Price, J. S., Waters, J. G., Darrah, C., Pennington, C., Edwards, D. R., Donell, S. T., & Clark, I. M. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00008.x · Cited by 386 · see citing works
Superoxide Reacts with Nitric Oxide to Nitrate Tyrosine at Physiological pH via Peroxynitrite
Reiter, C. D., Teng, R., & Beckman, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910433199 · Cited by 385 · see citing works
Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?
Severino, J., Allen, R. G., Balin, S., Balin, A., & Cristofalo, V. J. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4875 · Cited by 370 · see citing works
The overexpression of major antioxidant enzymes does not extend the lifespan of mice
Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00449.x · Cited by 353 · see citing works
Large‐scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
Aigner, T. G., Fundel, K., Saas, J., Gebhard, P. M., Haag, J., Weiß, T., Zien, A., Obermayr, F., Zimmer, R., & Bartnik, E. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22174 · Cited by 352 · see citing works
Association between the abnormal expression of matrix‐degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions
Roach, H. I., Yamada, N., Cheung, K. S. C., Tilley, S., Clarke, N. M. P., Oreffo, R. O. C., Kokubun, S., & Bronner, F. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21300 · Cited by 351 · see citing works
Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage: The age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage
Bank, R. A., Bayliss, M. T., Lafeber, F. P. J. G., Maroudas, A., & TeKoppele, J. M. (1998) · Biochemical Journal · doi:10.1042/bj3300345 · Cited by 343 · see citing works
Mechanisms of cellular senescence in human and mouse cells.
Itahana, K., Campisi, J., & Dimri, G. P. (2004) · Biogerontology · doi:10.1023/b:bgen.0000017682.96395.10 · Cited by 338 · see citing works
The effect of body weight on progression of knee osteoarthritis is dependent on alignment
Felson, D. T., Goggins, J., Niu, J., Zhang, Y., & Hunter, D. J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20726 · Cited by 331 · see citing works
Magnetic resonance imaging-determined synovial membrane volume as a marker of disease activity and a predictor of progressive joint destruction in the wrists of patients with rheumatoid arthritis
́stergaard, M., Hansen, M. S., Stoltenberg, M., Gideon, P., Klarlund, M., Jensen, K. E., & Lorenzen, I. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199905)42:5 · Cited by 323 · see citing works
Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial
Dougados, M., Nguyen, M., Berdah, L., Mazi�res, B., Vignon, E. P., Lequesne, M. G., & for the ECHODIAH Investigators Study Group (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200111)44:11 · Cited by 320 · see citing works
Molecular mechanisms of cartilage destruction: Mechanics, inflammatory mediators, and aging collide
Loeser, R. F. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21813 · Cited by 320 · see citing works
Self-citation
Cell death in cartilage
Kühn, K., DʼLima, D. D., Hashimoto, S., & Lotz, M. (2003) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2003.09.015 · Cited by 317 · see citing works
Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage–bone interface: A modeling study
Zhou, S., Cui, Z., & Urban, J. P. G. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20675 · Cited by 279 · see citing works
Increased oxidative stress with aging reduces chondrocyte survival: Correlation with intracellular glutathione levels
Carlo, M. D., & Loeser, R. F. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11338 · Cited by 254 · see citing works
Self-citation
Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13
Wu, W. K. K., Billinghurst, R. C., Pidoux, I., Antoniou, J., Zukor, D. J., Tänzer, M., & Poole, A. R. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10428 · Cited by 250 · see citing works
AGEing and osteoarthritis: a different perspective
Verzijl, N., Bank, R. A., TeKoppele, J. M., & DeGroot, J. (2003) · Current Opinion in Rheumatology · doi:10.1097/00002281-200309000-00016 · Cited by 248 · see citing works
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis
Loeser, R. F., Yammani, R. R., Carlson, C. S., Chen, H., Cole, A. A., Im, H., Bursch, L. S., & Yan, S. D. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21199 · Cited by 244 · see citing works
Self-citation
Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations
Müller, M. K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2104 · Cited by 237 · see citing works
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin‐1β and with chondrocyte resistance to insulin‐like growth factor 1
Loeser, R. F., Carlson, C. S., Carlo, M. D., & Cole, A. A. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10496 · Cited by 234 · see citing works
Self-citation
Telomere Erosion and Senescence in Human Articular Cartilage Chondrocytes
Martin, J. A., & Buckwalter, J. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.4.b172 · Cited by 232 · see citing works
Pathomechanisms of cartilage destruction by mechanical injury
Kurz, B., Lemke, A. K., Fay, J., Pufe, T., Grodzinsky, A. J., & Schünke, M. (2005) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2005.07.003 · Cited by 228 · see citing works
The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham Study.
Felson, D. T., Anderson, J. J., Naimark, A., Kannel, W. B., & Meenan, R. F. (1989) · PubMed · Cited by 223 · see citing works
Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification
Morita, K., Miyamoto, T. K., Fujita, N., Kubota, Y., Ito, K., Takubo, K., Miyamoto, K., Ninomiya, K., Suzuki, T., Iwasaki, R., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062525 · Cited by 219 · see citing works
Accumulation of advanced glycation end products as a molecular mechanism for aging as a risk factor in osteoarthritis
DeGroot, J., Verzijl, N., Wijk, M. J. G. W., van der Wurff‐Jacobs, K. M. G., El, B. V., van Roermund, P. M., Bank, R. A., Bijlsma, J. W. J., TeKoppele, J. M., & Lafeber, F. P. J. G. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20170 · Cited by 216 · see citing works
Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics
Ruíz‐Romero, C., Calamia, V., Mateos, J., Carreira, V., Martiénez-Gomariz, M., Fernaéndez, M., & Blanco, F. J. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800292-mcp200 · Cited by 208 · see citing works
Aggrecan Turnover in Human Articular Cartilage: Use of Aspartic Acid Racemization as a Marker of Molecular Age
Maroudas, A., Bayliss, M. T., Kaushansky, N., Schneiderman, R. S., & Gil‐Av, E. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0492 · Cited by 207 · see citing works
Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products
Yammani, R. R., Carlson, C. S., Bresnick, A. R., & Loeser, R. F. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22042 · Cited by 206 · see citing works
Self-citation
Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis
Taniguchi, N., Caramés, B., Ronfani, L., Ulmer, U., Komiya, S., Bianchi, M. E., & Lotz, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806062106 · Cited by 204 · see citing works
Sulfation of Chondroitin Sulfate in Human Articular Cartilage
Bayliss, M. T., Osborne, D. J., Woodhouse, S. M., & Davidson, C. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15892 · Cited by 204 · see citing works
Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity
Davidson, E. B., Scharstuhl, A., Vitters, E. L., van der Kraan, P., & van den Berg, W. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1833 · Cited by 201 · see citing works
Growth factor responsiveness of human articular chondrocytes in aging and development
Guerne, P., Blanco, F. J., Kaelin, A. C., Desgeorges, A., & Lotz, M. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380712 · Cited by 200 · see citing works
Age‐Related changes in cartilage proteoglycans: Quantitative electron microscopic studies
Buckwalter, J. A., Roughley, P. J., & Rosenberg, L. C. (1994) · Microscopy Research and Technique · doi:10.1002/jemt.1070280506 · Cited by 200 · see citing works
Age‐related decline in chondrocyte response to insulin‐like growth factor‐I: The role of growth factor binding proteins
Martin, J. A., Ellerbroek, S. M., & Buckwalter, J. A. (1997) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100150403 · Cited by 200 · see citing works
Some Biochemical and Biophysical Parameters for the Study of the Pathogenesis of Osteoarthritis: a Comparison Between the Processes of Ageing and Degeneration in Human Hip Cartilage
Грушко, Г. В., Schneiderman, R. S., & Maroudas, A. (1989) · Connective Tissue Research · doi:10.3109/03008208909043895 · Cited by 199 · see citing works
Localization of Tritiated Thymidine in Articular Cartilage of Rabbits
Mankin, H. J. (1962) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-196244040-00008 · Cited by 187 · see citing works
Relationship between time-integrated C-reactive protein levels and radiologic progression in patients with rheumatoid arthritis
Plant, M., Williams, A., O’Sullivan, M., Lewis, P. A., Coles, E. C., & Jessop, J. D. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200007)43:7 · Cited by 183 · see citing works
Self-citation
Inflammation-Induced Chondrocyte Hypertrophy Is Driven by Receptor for Advanced Glycation End Products
Cecil, D. L., Johnson, K., Rediske, J. J., Lotz, M., Schmidt, A. M., & Terkeltaub, R. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.8296 · Cited by 176 · see citing works
Biomarkers of frailty in older persons.
Ferrucci, L., Cavazzini, C., Corsi, A., Bartali, B., Russo, C. R., Lauretani, F., Ferrucci, L., Cavazzini, C., Corsi, A. M., Bartali, B., et al. (2002) · PubMed · Cited by 173 · see citing works
Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index
Mouritzen, U., Christgau, S., Lehmann, H.-J., Tankó, L. B., & Christiansen, C. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.4.332 · Cited by 169 · see citing works
Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis
Davies, C., Guilak, F., Weinberg, J. B., & Fermor, B. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.09.012 · Cited by 168 · see citing works
The risk of osteoarthritis with running and aging: a 5-year longitudinal study.
Lane, N. E., Michel, B. A., Björkengren, A. G., Oehlert, J. W., Shi, H., Bloch, D. A., & Fries, J. F. (1993) · PubMed · Cited by 166 · see citing works
Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1 induction, G2/M arrest, and apoptosis
Shao, Z., Alpaugh, M. L., Fontana, J. A., & Barsky, S. H. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19980401)69:1 · Cited by 165 · see citing works
Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: Possible involvement of caveolin 1–induced down‐regulation of articular chondrocytes in the pathogenesis of osteoarthritis
Dai, S., Shan, Z., Nakamura, H., Masuko, K., Kato, T., Nishioka, K., & Yudoh, K. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21639 · Cited by 160 · see citing works
Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes
Steenvoorden, M. M. C., Huizinga, T. W. J., Verzijl, N., Bank, R. A., Ronday, H. K., Luning, H. A. F., Lafeber, F. P. J. G., Toes, R. E. M., & DeGroot, J. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21523 · Cited by 149 · see citing works
Osteoarthritis and articular chondrocalcinosis in the elderly.
Wilkins, E. S., Dieppe, P. A., Maddison, P. J., & Evison, G. (1983) · Annals of the Rheumatic Diseases · doi:10.1136/ard.42.3.280 · Cited by 149 · see citing works
Extracellular superoxide dismutase and oxidant damage in osteoarthritis
Regan, E. A., Flannelly, J., Bowler, R. P., Tran, K. C., Nicks, M. E., Carbone, B. D., Glueck, D. H., Heijnen, H. F. G., Mason, R. M., & Crapo, J. D. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21387 · Cited by 140 · see citing works
Impact of mitochondrial ROS production in the pathogenesis of insulin resistance
Nishikawa, T., Kukidome, D., Sonoda, K., Fujisawa, K., Matsuhisa, T., Motoshima, H., Matsumura, T., & Araki, E. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.01.071 · Cited by 133 · see citing works
Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle
Temple, M. M., Bae, W. C., Chen, M. Q., Lotz, M., Amiel, D., Coutts, R. D., & Sah, R. L. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.03.005 · Cited by 131 · see citing works
Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage
Chen, A. C., Temple, M. M., Ng, D. M., Verzijl, N., DeGroot, J., TeKoppele, J. M., & Sah, R. L. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10627 · Cited by 126 · see citing works
Association between age and knee structural change: a cross sectional MRI based study
Ding, C., Cicuttini, F., Scott, F., Cooley, H., & Jones, G. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.023069 · Cited by 126 · see citing works
Reduction of Age-Associated Pathology in Old Mice by Overexpression of Catalase in Mitochondria
Treuting, P. M., Linford, N. J., Knoblaugh, S. E., Emond, M. J., Morton, J. F., Martin, G. M., Rabinovitch, P. S., & Ladiges, W. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.8.813 · Cited by 125 · see citing works
Increased Matrix Metalloproteinase-13 Production With Aging by Human Articular Chondrocytes in Response to Catabolic Stimuli
Forsyth, C. B., Cole, A. A., Murphy, G., Bienias, J. L., Im, H.-J., & Loeser, R. F. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.9.1118 · Cited by 125 · see citing works
Self-citation
Effects of Oxidative Damage and Telomerase Activity on Human Articular Cartilage Chondrocyte Senescence
Martin, J. A., Klingelhutz, A. J., Moussavi‐Harami, F., & Buckwalter, J. A. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.4.b324 · Cited by 123 · see citing works
Aged bovine chondrocytes display a diminished capacity to produce a collagen-rich, mechanically functional cartilage extracellular matrix
Tran‐Khanh, N., Hoemann, C. D., McKee, M. D., Henderson, J. E., & Buschmann, M. D. (2005) · Journal of Orthopaedic Research® · doi:10.1016/j.orthres.2005.05.009.1100230617 · Cited by 123 · see citing works
The Cell Density of Human Femoral Head Cartilage
Vignon, E. P., ARLOT, M. E., Lm, P., & Vignon, G. (1976) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-197611000-00044 · Cited by 119 · see citing works
Chondrocyte apoptosis in development, aging and disease
Horton, W. E., Feng, L., & Adams, C. S. (1998) · Matrix Biology · doi:10.1016/s0945-053x(98)90024-5 · Cited by 119 · see citing works
Localization of Tritiated Thymidine in Articular Cartilage of Rabbits
Mankin, H. J. (1963) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-196345030-00011 · Cited by 118 · see citing works
Nitric oxide inhibits chondrocyte response to IGF-I: inhibition of IGF-IRβ tyrosine phosphorylation
Studer, R., Levicoff, E., Georgescu, H. I., Miller, L. A., Jaffurs, D., & Evans, C. H. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.4.c961 · Cited by 115 · see citing works
Apoptosis of Chondrocytes in Transgenic Mice Lacking Collagen II
Yang, C., Li, S.-W., Helminen, H. J., Khillan, J. S., Bao, Y., & Prockop, D. J. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3692 · Cited by 112 · see citing works
Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro
Zhou, H. W. (2004) · Rheumatology · doi:10.1093/rheumatology/keh127 · Cited by 108 · see citing works
Vulnerability to ROS-induced cell death in ageing articular cartilage: The role of antioxidant enzyme activity
Jallali, N., Ridha, H., Thrasivoulou, C., Underwood, C. K., Butler, P. E. M., & Cowen, T. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.02.011 · Cited by 107 · see citing works
Multiple Signals Induce Endoplasmic Reticulum Stress in Both Primary and Immortalized Chondrocytes Resulting in Loss of Differentiation, Impaired Cell Growth, and Apoptosis
Yang, L., Carlson, S. G., McBurney, D. L., & Horton, W. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501069200 · Cited by 106 · see citing works
The α5β1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro
Pulai, J. I., Carlo, M. D., & Loeser, R. F. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10334 · Cited by 105 · see citing works
Self-citation
Aging, long-distance running, and the development of musculoskeletal disability
Lane, N. E., Bloch, D. A., Wood, P. D., & Fries, J. F. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90014-3 · Cited by 101 · see citing works
Clinical Aspects of Calcium Pyrophosphate Dihydrate Crystal Deposition
Doherty, M., & Dieppe, P. A. (1988) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(21)00972-8 · Cited by 100 · see citing works
Heterochromatin and its Relationship to Cell Senescence and Cancer Therapy
Zhang, R.-G., & Adams, P. (2007) · Cell Cycle · doi:10.4161/cc.6.7.4079 · Cited by 99 · see citing works
Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13
Long, D. L., Blake, S. M., Song, X. Y. R., Lark, M. W., & Loeser, R. F. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2376 · Cited by 94 · see citing works
Self-citation
Apoptosis in osteoarthritis
Aigner, T. G., Kim, H. A., & Roach, H. I. (2004) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2004.04.002 · Cited by 94 · see citing works
Release of oxygen radicals by articular chondrocytes: A study of luminol-dependent chemiluminescence and hydrogen peroxide secretion
Rathakrishnan, C., Tiku, K., Raghavan, A., & TIKU, M. L. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650071005 · Cited by 93 · see citing works
Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro
Bobacz, K., Gruber, R., Soleiman, A., Erlacher, L., Smolen, J. S., & Graninger, W. B. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11248 · Cited by 91 · see citing works
Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments
Carlo, M. D., Schwartz, D., Erickson, E. A., & Loeser, R. F. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.035 · Cited by 84 · see citing works
Self-citation
Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
Dudhia, J., Davidson, C. M., Wells, T. E., VYNIOS, D. H., Hardingham, T., & Bayliss, M. T. (1996) · Biochemical Journal · doi:10.1042/bj3130933 · Cited by 83 · see citing works
Age-related changes in cartilage endogenous osteogenic protein-1 (OP-1)
Chubinskaya, S., Kumar, B., Merrihew, C., Heretis, K., Rueger, D. C., & Kuettner, K. E. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00158-8 · Cited by 79 · see citing works
Intracellular determinants of cell aging
Hayflick, L. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90018-6 · Cited by 74 · see citing works
Transglutaminase activity in aging articular chondrocytes and articular cartilage vesicles
Rosenthal, A. K., Derfus, B. A., & Henry, L. A. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400526 · Cited by 73 · see citing works
Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study
Zhai, G., Aviv, A., Hunter, D. J., Hart, D. J., Gardner, J. P., Kimura, M., Lu, X., Valdes, A. M., & Spector, T. D. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.056903 · Cited by 72 · see citing works
Replicative aging of human articular chondrocytes during ex vivo expansion
Parsch, D., Brümmendorf, T. H., Richter, W., & Fellenberg, J. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10626 · Cited by 67 · see citing works
Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage
Loeser, R., Im, H.-J., Richardson, B., Lu, Q., & Chubinskaya, S. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.08.003 · Cited by 67 · see citing works
Self-citation
Age-related changes in the composition, the molecular stoichiometry and the stability of proteoglycan aggregates extracted from human articular cartilage
Wells, T. E., Davidson, C. M., Mörgelin, M., Bird, J., Bayliss, M. T., & Dudhia, J. (2003) · Biochemical Journal · doi:10.1042/bj20020968 · Cited by 63 · see citing works
Articular chondrocytes from aging rats respond poorly to insulin-like growth factor-1: an altered signaling pathway
Messai, H., Duchossoy, Y., Khatib, A., Panasyuk, A., & Mitrovic, D. R. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00107-x · Cited by 60 · see citing works
Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice
Scharstuhl, A., van Beuningen, H. M., Vitters, E. L., van der Kraan, P. M., & van den Berg, W. B. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.12.1095 · Cited by 59 · see citing works
DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage
Pöschl, E., Fidler, A., Schmidt, B., Kallipolitou, A., Schmid, E., & Aigner, T. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.022509 · Cited by 59 · see citing works
Matrix homeostasis in aging normal human ankle cartilage
Aurich, M. E., Poole, A. R., Reiner, A., Mollenhauer, C., Margulis, A., Kuettner, K. E., & Cole, A. A. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10611 · Cited by 58 · see citing works
Mitochondrial proteomic characterization of human normal articular chondrocytes
Ruíz‐Romero, C., López-Armada, M. J., & Blanco, F. J. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.12.004 · Cited by 57 · see citing works
Genes, telomeres and mammalian ageing
Goyns, M. H. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00424-9 · Cited by 54 · see citing works
Age-Related Effects of TGF-β on Proteoglycan Synthesis in Equine Articular Cartilage
Iqbal, J., Dudhia, J., Bird, J., & Bayliss, M. T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3167 · Cited by 51 · see citing works
Chondrocyte antioxidant defences: the roles of catalase and glutathione peroxidase in protection against H2O2 dependent inhibition of proteoglycan biosynthesis.
Baker, M. S., Feigan, J., & Lowther, D. A. (1988) · PubMed · Cited by 45 · see citing works
Increasing age at symptom onset is associated with worse radiological damage at presentation in patients with early inflammatory polyarthritis
Bukhari, M. A. S., Lunt, M., Barton, A. C., Bunn, D. K., Silman, A. J., & Symmons, D. P. M. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.055657 · Cited by 44 · see citing works
Modulation of Intracellular Reactive Oxygen Species Level in Chondrocytes by IGF-1, FGF, and TGF-β1
Jallali, N., Ridha, H., Thrasivoulou, C., Butler, P. E. M., & Cowen, T. (2007) · Connective Tissue Research · doi:10.1080/03008200701331516 · Cited by 40 · see citing works
Morphology of sites of adhesion between hepatic stellate cells (vitamin A-storing cells) and a three-dimensional extracellular matrix
Imai, K., & Senoo, H. (1998) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199804)250:4 · Cited by 34 · see citing works
A novel role for Bcl‐2 associated‐athanogene‐1 (Bag‐1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes
Yang, L., McBurney, D. L., Tang, S., Carlson, S. G., & Horton, W. E. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21328 · Cited by 24 · see citing works
Age‐related expression patterns of Bag‐1 and Bcl‐2 in growth plate and articular chondrocytes
Kinkel, M. D., Yagi, R., McBurney, D. L., Nugent, A. E., & Horton, W. E. (2004) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.20063 · Cited by 22 · see citing works
Peroxide accumulation without major mitochondrial alteration in replicative senescence
Pfeuty, A., & Guéride, M. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01188-1 · Cited by 16 · see citing works
Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus
Gergely, P., Grossman, C., Niland, B., Puskas, F., Neupane, H., Allam, F., Banki, K., Phillips, P. E., & Perl, A. (2002) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200201)46:1 · Cited by 5 · see citing works
Untitled work
Blais (1997) · doi:10.1002/1529-0131(199707)40:7
Untitled work
Pope (2001) · doi:10.1002/1529-0131(200106)44:6
Untitled work
Atsumi (2000) · doi:10.1002/1529-0131(200009)43:9
Self-citation
Untitled work
Komuro (2001) · doi:10.1002/1529-0131(200112)44:12

Flagged first, then by citations

5 of the 130 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

[113]Pelletier JP Martel-Pelletier J Abramson SB Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets Arthritis Rheum 2001 44 1237 1247 11407681

Sorted by citations

Osteoarthritis: A disease of the joint as an organ
Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34453 · Cited by 3,129 · see citing works
Self-citation
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363 · see citing works
Osteoarthritis: an update with relevance for clinical practice
Bijlsma, J. W. J., Berenbaum, F., & Lafeber, F. P. J. G. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60243-2 · Cited by 2,301 · see citing works
Osteoarthritis
Martel-Pelletier, J., Barr, A., Cicuttini, F., Conaghan, P., Cooper, C., Goldring, M. B., Goldring, S. R., Jones, G., Teichtahl, A., & Pelletier, J. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.72 · Cited by 49 · see citing works
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Jeon, O. H., Kim, C., Laberge, R.-M., Demaria, M., Rathod, S., Vasserot, A. P., Chung, J. W., Kim, D. H., Poon, Y., David, N., et al. (2017) · Nature Medicine · doi:10.1038/nm.4324 · Cited by 1,515 · see citing works
Senescence and aging: Causes, consequences, and therapeutic avenues
McHugh, D., & Gil, J. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201708092 · Cited by 1,233 · see citing works
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Chen, D., Shen, J., Zhao, W.-W., Wang, T.-Y., Han, L., Hamilton, J., & Im, H. (2017) · Bone Research · doi:10.1038/boneres.2016.44 · Cited by 1,146 · see citing works
ROS/oxidative stress signaling in osteoarthritis.
Lepetsos, P., & Papavassiliou, A. (2016) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2016.01.003 · Cited by 776 · see citing works
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
Coryell, P. R., Diekman, B. O., & Loeser, R. F. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00533-7 · Cited by 761 · see citing works
Self-citation
The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis.
Zheng, L.-L., Zhang, Z.-J., Sheng, P., & Mobasheri, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101249 · Cited by 717 · see citing works
Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory
Gupta, R. C., Lall, R., Srivastava, A., & Sinha, A. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00192 · Cited by 662 · see citing works
Mitochondrial dysfunction and the inflammatory response
López-Armada, M. J., Riveiro-Naveira, R. R., Vaamonde‐García, C., & Valcarcel‐Ares, M. N. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.01.003 · Cited by 528 · see citing works
Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration
Wang, F., Cai, F., Shi, R., Wang, X.-H., & Wu, X. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.09.019 · Cited by 526 · see citing works
Oxidative stress in bone remodelling and disease
Wauquier, F., Léotoing, L., Coxam, V., Guicheux, J., & Wittrant, Y. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.08.004 · Cited by 489 · see citing works
Chondrocyte dedifferentiation and osteoarthritis (OA)
Charlier, E., Deroyer, C., Ciregia, F., Malaise, O., Neuville, S., Plener, Z., Malaise, M., & de Seny, D. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.02.036 · Cited by 464 · see citing works
Autophagy activation by rapamycin reduces severity of experimental osteoarthritis
Caramés, B., Hasegawa, A., Taniguchi, N., Miyaki, S., Blanco, F. J., & Lotz, M. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200557 · Cited by 458 · see citing works
Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis
He, L., He, T., Xing, J., Zhou, Q., Fan, L., Liu, C., Chen, Y., Wu, D.-P., Tian, Z., Liu, B., et al. (2020) · Stem cell research & therapeutics · doi:10.1186/s13287-020-01781-w · Cited by 392 · see citing works
Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis.
Ayhan, E., Kesmezacar, H., & Akgun, I. (2014) · World Journal of Orthopaedics · doi:10.5312/wjo.v5.i3.351 · Cited by 445 · see citing works
Biomechanical considerations in the pathogenesis of osteoarthritis of the knee
Heijink, A., Gomoll, A. H., Madry, H., Drobnič, M., Filardo, G., Espregueira‐Mendes, J., & van Dijk, C. N. (2011) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-011-1818-0 · Cited by 417 · see citing works
Effects of aging on articular cartilage homeostasis
Lotz, M., & Loeser, R. F. (2012) · Bone · doi:10.1016/j.bone.2012.03.023 · Cited by 393 · see citing works
Self-citation
Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models
He, Y., Li, Z. A., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020) · Biology · doi:10.3390/biology9080194 · Cited by 400 · see citing works
Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges.
Rahmati, M., Mobasheri, A., & Mozafari, M. (2016) · Bone · doi:10.1016/j.bone.2016.01.019 · Cited by 365 · see citing works
Stigmasterol: A phytosterol with potential anti-osteoarthritic properties
Gabay, O., Sanchez, C., Salvat, C., Chevy, F., Breton, M., Nourissat, G., Wolf, C., Jacques, C., & Berenbaum, F. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.08.019 · Cited by 375 · see citing works
Adipose-Derived Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis: A Randomized Controlled Trial
Freitag, J., Bates, D., Wickham, J. B., Shah, K., Huguenin, L., Tenen, A., Paterson, K. L., & Boyd, R. L. (2019) · Regenerative Medicine · doi:10.2217/rme-2018-0161 · Cited by 369 · see citing works
Senescent cells and osteoarthritis: a painful connection
Jeon, O. H., David, N. E., Campisi, J., & Elisseeff, J. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95147 · Cited by 354 · see citing works
Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice
Xu, M., Bradley, E. W., Weivoda, M. M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., et al. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw154 · Cited by 352 · see citing works
Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis
Buhrmann, C., Mobasheri, A., & Shakibaei, M. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2850 · Cited by 318 · see citing works
Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA
Lotz, M. K., & Caramés, B. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.109 · Cited by 314 · see citing works
Macroscale delivery systems for molecular and cellular payloads
Kearney, C. J., & Mooney, D. J. (2013) · Nature Materials · doi:10.1038/nmat3758 · Cited by 300 · see citing works
Cartilage tissue engineering: Molecular control of chondrocyte differentiation for proper cartilage matrix reconstruction
Demoor, M., Ollitrault, D., Gómez-Leduc, T., Bouyoucef, M., Hervieu, M., Fabre, H., Lafont, J. E., Denoix, J., Audigié, F., Mallein‐Gérin, F., et al. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.02.030 · Cited by 298 · see citing works
Chondrocyte and mesenchymal stem cell-based therapies for cartilage repair in osteoarthritis and related orthopaedic conditions
Mobasheri, A., Gauthaman, K., Musumeci, G., & Batt, M. E. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.04.017 · Cited by 283 · see citing works
Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy – a review
Freitag, J., Bates, D., Boyd, R. L., Shah, K., Barnard, A., Huguenin, L., & Tenen, A. (2016) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-016-1085-9 · Cited by 283 · see citing works
Cartilage cell clusters
Lotz, M., Otsuki, S., Grogan, S. P., Sah, R. L., Terkeltaub, R. A., & DʼLima, D. D. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27528 · Cited by 241 · see citing works
A Review of the Effects of Collagen Treatment in Clinical Studies
Wang, H. (2021) · Polymers · doi:10.3390/polym13223868 · Cited by 239 · see citing works
Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy
Hu, S., Zhang, C., Ni, L., Huang, C., Chen, D., Shi, K., Jin, H., Zhang, K., Li, Y., Xie, L., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2680-0 · Cited by 236 · see citing works
Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1−SMAD1 interaction
Lian, C., Wang, X., Qiu, X., Wu, Z., Gao, B., Liu, L., Liang, G., Zhou, H., Yang, X., Peng, Y., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0046-y · Cited by 234 · see citing works
Inflammation and epigenetic regulation in osteoarthritis
Shen, J., Abu‐Amer, Y., O’Keefe, R. J., & McAlinden, A. (2016) · Connective Tissue Research · doi:10.1080/03008207.2016.1208655 · Cited by 229 · see citing works
p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis
Philipot, D., Guérit, D., Platano, D., Chuchana, P., Olivotto, E., Espinoza, F., Dorandeu, A., Pers, Y.-M., Piette, J., Borzi, R. M., et al. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4494 · Cited by 226 · see citing works
Microarray analysis reveals age‐related differences in gene expression during the development of osteoarthritis in mice
Loeser, R. F., Olex, A. L., McNulty, M. A., Carlson, C. S., Callahan, M. F., Ferguson, C. M., Chou, J., Leng, X., & Fetrow, J. S. (2012) · Arthritis & Rheumatism · doi:10.1002/art.33388 · Cited by 222 · see citing works
Self-citation
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity
Dudek, M., Gossan, N. C., Yang, N., Im, H., Ruckshanthi, J. P. D., Yoshitane, H., Li, X., Jin, D., Wang, P., Boudiffa, M., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci82755 · Cited by 221 · see citing works
Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults
Safdar, A., Hamadeh, M. J., Kaczor, J. J., Raha, S., deBeer, J., & Tarnopolsky, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010778 · Cited by 217 · see citing works
Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis
Mobasheri, A., Matta, C., Zákány, R., & Musumeci, G. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.12.003 · Cited by 218 · see citing works
Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis
Teeple, E. A., Jay, G. D., Elsaid, K. A., & Fleming, B. C. (2013) · The AAPS Journal · doi:10.1208/s12248-013-9454-x · Cited by 212 · see citing works
The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date
Oo, W. M., Little, C. B., Duong, V., & Hunter, D. J. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s295224 · Cited by 212 · see citing works
Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage
Hui, W., Young, D. A., Rowan, A. D., Xu, X., Cawston, T. E., & Proctor, C. J. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-206295 · Cited by 202 · see citing works
Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration
Ashraf, S., Cha, B.-H., Kim, J.-S., Ahn, J., Han, I., Park, H., & Lee, S.-H. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.07.008 · Cited by 195 · see citing works
The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies
Kang, D., Lee, J., Wu, C., Guo, X., Lee, B. J., Chun, J., & Kim, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0408-y · Cited by 192 · see citing works
Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers
Jeon, O. H., Wilson, D. R., Clement, C. C., Rathod, S., Cherry, C., Powell, B. H., Lee, Z., Khalil, A. M., Green, J. J., Campisi, J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.125019 · Cited by 186 · see citing works
Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis
Han, Z., Wang, K., Ding, S., & Zhang, M. (2024) · Bone Research · doi:10.1038/s41413-024-00375-z · Cited by 189 · see citing works
Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration
Fan, Y., Bian, X.-Z., Meng, X., Li, L., Fu, L.-Y., Zhang, Y.-N., Wang, L., Zhang, Y., Gao, D.-L., Guo, X., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224420 · Cited by 187 · see citing works
Efficacy of Ultrasound-guided Intra-articular Injections of Platelet-rich Plasma Versus Hyaluronic Acid for Hip Osteoarthritis
Battaglia, M., Guaraldi, F., Vannini, F., Rossi, G., Timoncini, A., Buda, R., & Giannini, S. (2013) · Orthopedics · doi:10.3928/01477447-20131120-13 · Cited by 176 · see citing works
Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis
Portal‐Núñez, S., Esbrit, P., Alcaraz, M. J., & Largo, R. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.12.012 · Cited by 170 · see citing works
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis
D'Amico, D., Olmer, M., Fouassier, A. M., Valdés, P., Andreux, P. A., Rinsch, C., & Lotz, M. (2022) · Aging Cell · doi:10.1111/acel.13662 · Cited by 170 · see citing works
Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α
Terkeltaub, R. A., Yang, B., Lotz, M., & Liu‐Bryan, R. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30333 · Cited by 168 · see citing works
Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes
Vaamonde‐García, C., Riveiro-Naveira, R. R., Valcarcel‐Ares, M. N., Hermida-Carballo, L., Blanco, F. J., & López-Armada, M. J. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34508 · Cited by 161 · see citing works
Mitochondria: Are they causal players in cellular senescence?
Correia-Melo, C., & Passos, J. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.017 · Cited by 160 · see citing works
Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice
Zheng, W., Feng, Z., You, S., Zhang, H., Tao, Z., Wang, Q., Chen, H., & Wu, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.02.009 · Cited by 160 · see citing works
Micromass co-culture of human articular chondrocytes and human bone marrow mesenchymal stem cells to investigate stable neocartilage tissue formation in vitro
Giovannini, S., Diaz‐Romero, J., Aigner, T. G., Heini, P., Mainil‐Varlet, P., & Nesic, D. (2010) · European Cells and Materials · doi:10.22203/ecm.v020a20 · Cited by 156 · see citing works
Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes
Ntoumou, E., Tzetis, M., Braoudaki, M., Lambrou, G. Ι., Poulou, M., Malizos, Κ. Ν., Stefanou, N., Anastasopoulou, L., & Tsezou, A. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0428-1 · Cited by 156 · see citing works
Extracellular Vesicles from Adipose‐Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts
Tofiño-Vian, M., Guillén, M. I., del Caz, M. D. P., Castejón, M. A., & Alcaraz, M. J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7197598 · Cited by 154 · see citing works
Self-assembled hyaluronic acid nanoparticles for osteoarthritis treatment
Kang, L., Yoon, J., Rho, J. G., Han, H. S., Lee, S., Oh, Y. S., Kim, I. H., Kim, E., Kim, S. J., Lim, Y. T., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120967 · Cited by 154 · see citing works
Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis
Mavrogonatou, E., Pratsinis, H., Papadopoulou, A., Karamanos, N. K., & Kletsas, D. (2019) · Matrix Biology · doi:10.1016/j.matbio.2017.10.004 · Cited by 153 · see citing works
Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development
Kang, D., Shin, J., Cho, Y., Kim, H.-S., Gu, Y.-R., Kim, H., You, K. T., Chang, M. J., Chang, C. B., Kang, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aar6659 · Cited by 148 · see citing works
Autophagy in osteoarthritis.
Li, Y.-S., Zhang, F.-J., Zeng, C., Luo, W., Xiao, W.-F., Gao, S.-G., & Lei, G.-H. (2016) · Joint, bone, spine : revue du rhumatisme · doi:10.1016/j.jbspin.2015.06.009 · Cited by 110 · see citing works
Biology and pathology of Rho GTPase, PI‐3 kinase‐Akt, and MAP kinase signaling pathways in chondrocytes
Beier, F., & Loeser, R. F. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22604 · Cited by 138 · see citing works
Self-citation
The Role of Aging in the Development of Osteoarthritis.
Loeser, R. F. (2017) · Europe PMC (PubMed Central) · Cited by 137 · see citing works
Self-citation
Role of the inflammation-autophagy-senescence integrative network in osteoarthritis
Vinatier, C., Domínguez, E., Guicheux, J., & Caramés, B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00706 · Cited by 135 · see citing works
TGF-b signaling in cartilage homeostasis and osteoarthritis
Philip, A. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s266 · Cited by 133 · see citing works
Osteoarthritis: Another Component of Metabolic Syndrome?
Velasquez, M. T., & Katz, J. D. (2010) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2009.0110 · Cited by 132 · see citing works
Cellular senescence in aging and osteoarthritis
Toh, W. S., Brittberg, M., Farr, J., Foldager, C. B., Gomoll, A. H., Hui, J. H. P., Richardson, J. B., Roberts, S., & Spector, M. (2016) · Acta Orthopaedica · doi:10.1080/17453674.2016.1235087 · Cited by 130 · see citing works
Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age
Rezuş, E., Burlui, A., Cardoneanu, A., Rezuș, C., Codreanu, C., Parvu, M., Zota, G. R., & Tamba, B.-I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020592 · Cited by 117 · see citing works
Physical activity ameliorates cartilage degeneration in a rat model of aging: a study on lubricin expression
Musumeci, G., Castrogiovanni, P., Trovato, F. M., Imbesi, R., Giunta, S., Szychlinska, M. A., Loreto, C., Castorina, S., & Mobasheri, A. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12290 · Cited by 115 · see citing works
The role of sirtuin 1 and its activator, resveratrol in osteoarthritis
Deng, Z., Li, Y.-S., Liu, H., Xiao, S., Li, L.-J., Tian, J., Cheng, C., Zhang, G., & Zhang, F.-J. (2019) · Bioscience Reports · doi:10.1042/bsr20190189 · Cited by 96 · see citing works
Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes
Nagai, K., Matsushita, T., Matsuzaki, T., Takayama, K., Matsumoto, T., Kuroda, R., & Kurosaka, M. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.03.024 · Cited by 110 · see citing works
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in osteoarthritis
Zhao, S., Xiu, G., Wang, J., Wen, Y., Lu, J., Wu, B., Wang, G., Yang, D., Ling, B., Du, D., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02086-9 · Cited by 109 · see citing works
Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes
Hoff, P., Buttgereit, F., Burmester, G., Jakstadt, M., Gaber, T., Andreas, K., Matziolis, G., Perka, C., & Röhner, E. (2012) · International Orthopaedics · doi:10.1007/s00264-012-1724-1 · Cited by 101 · see citing works
The Future of Osteoarthritis Therapeutics: Targeted Pharmacological Therapy
Mobasheri, A. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-013-0364-9 · Cited by 109 · see citing works
ERK‐1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts
Prasadam, I., van Gennip, S., Friis, T., Shi, W., Crawford, R., & Xiao, Y. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27397 · Cited by 108 · see citing works
The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis
He, Y., Wu, Z., Xu, L., Xu, K., Chen, Z., Ran, J., & Wu, L. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03497-9 · Cited by 106 · see citing works
Cell Interplay in Osteoarthritis
Li, Z., Huang, Z., & Bai, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.720477 · Cited by 108 · see citing works
Aging and Oxidative Stress Reduce the Response of Human Articular Chondrocytes to Insulin‐like Growth Factor 1 and Osteogenic Protein 1
Loeser, R. F., Gandhi, U., Long, D. L., Yin, W., & Chubinskaya, S. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38641 · Cited by 104 · see citing works
Self-citation
The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets.
Endisha, H., Rockel, J., Jurisica, I., & Kapoor, M. (2018) · JCI Insight · doi:10.1172/jci.insight.121630 · Cited by 101 · see citing works
Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis
Yang, H., Chen, C., Chen, H., Duan, X., Li, J., Zhou, Y., Zeng, W., & Yang, L. (2020) · Aging · doi:10.18632/aging.103177 · Cited by 105 · see citing works
Inflammatory and Metabolic Signaling Interfaces of the Hypertrophic and Senescent Chondrocyte Phenotypes Associated with Osteoarthritis
Horváth, E., Sólyom, Á., Székely, J., Nagy, E. E., & Popoviciu, H. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216468 · Cited by 104 · see citing works
Conceitos atuais em osteoartrite
de Rezende, M. U., de Campos, G. C., & Pailo, A. F. (2013) · Acta Ortopédica Brasileira · doi:10.1590/s1413-78522013000200010 · Cited by 101 · see citing works
Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis
Adães, S., Mendonça, M., Santos, T. N., Castro‐Lopes, J. M., Ferreira‐Gomes, J., & Neto, F. L. M. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4436 · Cited by 100 · see citing works
Identifying and Treating Preclinical and Early Osteoarthritis
Felson, D. T., & Hodgson, R. J. (2014) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2014.07.012 · Cited by 98 · see citing works
Cartilage repair in the degenerative ageing knee
Brittberg, M., Gomoll, A. H., Canseco, J. A., Far, J., Lind, M., & Hui, J. H. P. (2016) · Acta Orthopaedica · doi:10.1080/17453674.2016.1265877 · Cited by 98 · see citing works
Dance between biology, mechanics, and structure: A systems‐based approach to developing osteoarthritis prevention strategies
Chu, C. R., & Andriacchi, T. P. (2015) · Journal of Orthopaedic Research® · doi:10.1002/jor.22817 · Cited by 97 · see citing works
Glucosamine Activates Autophagy In Vitro and In Vivo
Caramés, B., Kiosses, W. B., Akasaki, Y., Brinson, D. C., Eap, W., Koziol, J. A., & Lotz, M. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37977 · Cited by 96 · see citing works
Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis
Zhang, M., Mani, S. B., He, Y., Hall, A. M., Xu, L., Li, Y., Zurakowski, D., Jay, G. D., & Warman, M. L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83676 · Cited by 95 · see citing works
Conserved senescence associated genes and pathways in primary human fibroblasts detected by RNA-seq
Marthandan, S., Baumgart, M., Priebe, S., Groth, M., Schaer, J., Kaether, C., Guthke, R., Cellerino, A., Platzer, M., Diekmann, S., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154531 · Cited by 91 · see citing works
Mechanical stress abnormalities promote chondrocyte senescence - The pathogenesis of knee osteoarthritis
Jiang, W., Chen, H., Lin, Y., Cheng, K., Zhou, D., Chen, R., Song, C., Zeng, L., & Yu, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115552 · Cited by 98 · see citing works
Articular Chondrocyte Phenotype Regulation through the Cytoskeleton and the Signaling Processes That Originate from or Converge on the Cytoskeleton: Towards a Novel Understanding of the Intersection between Actin Dynamics and Chondrogenic Function
Lauer, J. C., Selig, M., Hart, M. L., Kurz, B., & Rolauffs, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063279 · Cited by 92 · see citing works
Management of knee osteoarthritis. Current status and future trends
Ondrésik, M., Maia, F. R., Morais, A. D. S., Gertrudes, A. C., Bacelar, A. H. D., Correia, C. O., Gonçalves, C., Radhouani, H., Sousa, R. A., Oliveira, J. M., et al. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.26182 · Cited by 91 · see citing works
Autophagy in osteoarthritis
Jeon, H., & Im, G. (2016) · Connective Tissue Research · doi:10.1080/03008207.2016.1240790 · Cited by 91 · see citing works
The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond
Berenbaum, F., & Meng, Q. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.93 · Cited by 91 · see citing works
TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis
Yoon, D. S., Lee, K., Choi, Y., Ko, E. A., Lee, N., Cho, S., Park, K. H., Lee, J., Kim, H., & Lee, J. W. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-021-00925-6 · Cited by 89 · see citing works
Interventions for age-related diseases: Shifting the paradigm
Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 87 · see citing works
BMSCs‐Derived Exosomes Ameliorate Pain Via Abrogation of Aberrant Nerve Invasion in Subchondral Bone in Lumbar Facet Joint Osteoarthritis
Li, J., Ding, Z., Li, Y., Wang, W., Wang, J., Yu, H., Liu, A., Miao, J., Chen, S., Wu, T., et al. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24497 · Cited by 88 · see citing works

Authors: Loeser, R. F.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: Loeser, R.F.
ORCID: Loeser, R.F.
Venue: Osteoarthritis and Cartilage
Publisher: Elsevier BV
Published: 2009-08
Volume: 17
Issue: 8
Pages: 971-979
ISSN: 1063-4584 (ISSN-L)
DOI: 10.1016/j.joca.2009.03.002
PMC: PMC2713363
OpenAlex: W2025243746
Cited by: 726
References: 130
Citations by year: 2026: 39 · 2025: 55 · 2024: 48 · 2023: 51 · 2022: 39 · 2021: 75 · 2020: 57 · 2019: 48 · 2018: 35 · 2017: 46 · 2016: 43 · 2015: 49 · 2014: 36 · 2013: 29 · 2012: 27
FWCI: 3.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1661 d)
Locations: Osteoarthritis and Cartilage (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG016697, R01-AG-16697, P30AG021332)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR49003, R01AR049003)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords: osteoarthritis, aging, chondrocyte senescence, articular cartilage, oxidative stress, replicative senescence, extracellular matrix, glycation, pro-inflammatory mediators, matrix-degrading enzymes, cartilage homeostasis
MeSH terms: Aging, Animals, Cartilage, Articular, Humans, Osteoarthritis, Oxidative Stress, Chondrocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks