The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Baseline knee adduction and flexion moments during walking are both associated with 5 year cartilage changes in patients with medial knee osteoarthritis
Open accessAbstract
Objective To test the hypothesis that knee cartilage changes over five years are associated with baseline peak knee adduction moment (KAM) and peak knee flexion moment (KFM) during early stance. Design Baseline KAM and KFM were measured in sixteen subjects with medial knee OA. Regional changes in cartilage thickness and changes in medial-to-lateral thickness ratio were quantified using magnetic resonance imaging at baseline and again after five years. Multiple regression was used to determine whether baseline measures of KAM and KFM were associated with cartilage changes over five years. Associations with baseline pain score, Kellgren-Lawrence grade, walking speed, age, gender, and body mass index were tested one-by-one in the presence of KAM and KFM. Results Changes over five years in femoral medial-to-lateral thickness ratio were associated with baseline KAM, KFM, and pain score (R2=0.60, p=0.010), and most significantly with KAM (R2=0.33, p=0.019). Changes in tibial medial-to-lateral thickness ratio were associated with baseline KAM, KFM, and walking speed (R2=0.49, p=0.039), with KFM driving this association (R2=0.40, p=0.009). Changes in medial tibial thickness were associated with baseline KAM, KFM, and walking speed (R2=0.49, p=0.041); KFM also drove this association (R2=0.42, p=0.006). Conclusions The findings that the KAM has a greater influence on femoral cartilage change and the KFM has a greater influence on tibial cartilage change provide new insight into the tibiofemoral variations in cartilage changes associated with walking kinetics. These results suggest that both KAM and KFM should be considered when designing disease interventions as well as when assessing the risk for OA progression.
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Cited by
Hatfield, G. L., Costello, K. E., Astephen Wilson, J. L., Stanish, W. D., & Hubley-Kozey, C. L. (2021) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2021.03.038 · Cited by 15
Metadata
- Authors
- Chehab, E. F., Favre, J., Erhart-Hledik, J. C., & Andriacchi, T. P.
- Venue
- Osteoarthritis and Cartilage
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 22
- Issue
- 11
- Pages
- 1833-1839
- ISSN
- 1063-4584 (ISSN-L)
- OpenAlex
- W2046076789
- Cited by
- 353
- References
- 29
- FWCI
- 21.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
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- Chehab, E. F., Favre, J., Erhart-Hledik, J. C., & Andriacchi, T. P. (2014). Baseline knee adduction and flexion moments during walking are both associated with 5 year cartilage changes in patients with medial knee osteoarthritis. Osteoarthritis and Cartilage. https://doi.org/10.1016/j.joca.2014.08.009
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