Cited by 118Osteoarthritis Treatment and MechanismsHip disorders and treatmentsMusculoskeletal pain and rehabilitation

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Cartilage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip osteoarthritis (OA) diagnosis: a systematic review and meta-analysis

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Hao, H.Q., Zhang, J.F., He, Q.Q., Wang, Z.·2019·Osteoarthritis and Cartilage

DOI 10.1016/j.joca.2018.10.009

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Abstract

Objective This study was design to examine the diagnostic performance of cartilage oligomeric matrix protein (COMP), C-terminal cross-linking telopeptide of type II collagen (CTX-II), and matrix metalloproteinase-3 (MMP-3) as biomarker for knee and hip OA. Methods Systematic search on multiple databases was completed in January 2018 using certain keywords. COMP, CTX-II, MMP-3 levels in knee and hip OA patients and healthy individuals were collected and calculated. Differences between subgroups were expressed as standardized mean differences (SMD). Subgroup analyses were performed to compare COMP, CTX-II, and MMP-3 performance between measuring sources, genders, large and small sample size and diagnostic criteria for OA patients. Results A moderate performance of COMP in distinguishing between knee (SMD: 0.68; 95% confidence intervals (CI): 0.43-0.93; P < 0.0001) or hip (SMD: 0.25; 95% CI, 0.10, 0.40; P = 0.0008) OA patients and controls were found. CTX-II showed a moderated standardised mean differences (SMD) of 0.48 (95% CI, 0.32, 0.64; P < 0.0001) in the detection of knee OA and a large SMD of 0.76 (95% CI, 0.09, 1.42; P = 0.03) in diagnosing hip OA. A small SMD of 0.32 (95% CI, -0.03, 0.67; P = 0.07) was found for MMP-3 performance and the results did not reach statistic significance. Progression study revealed potential effectiveness of serum COMP in predicting OA progression. Subgroup analysis showed that serum COMP and urinary CTX-II performed better in male than female. Study size and diagnostic criteria did not significantly influence the pooled SMD, but they might be the sources of heterogeneity among studies. Conclusion The overall results indicates that serum COMP and urinary CTX-II can distinguish between knee or hip OA patients and control subjects. Serum COMP is effective in predicting OA progression.Further researches with rigorous study design and a larger sample size are required to validate our findings.

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Authors: Hao, H. Q., Zhang, J. F., He, Q. Q., & Wang, Z.
Affiliations: Shanxi University of Traditional Chinese Medicine (CN)
Shanxi Medical University (CN)
Corresponding author: Zhang, J.F.
ORCID: Zhang, J.F.
He, Q.Q.
Venue: Osteoarthritis and Cartilage
Publisher: Elsevier BV
Published: 2019-05
Volume: 27
Issue: 5
Pages: 726-736
ISSN: 1063-4584 (ISSN-L)
DOI: 10.1016/j.joca.2018.10.009
OpenAlex: W2899068696
Cited by: 118
References: 88
Citations by year: 2026: 11 · 2025: 15 · 2024: 13 · 2023: 32 · 2022: 14 · 2021: 10 · 2020: 17 · 2019: 6
FWCI: 1.37
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Osteoarthritis and Cartilage (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81573245, 81102198)
Shanxi provincial health Commission projects (2018GW09, 2014169)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Health Sciences › Medicine › Surgery › Hip disorders and treatments
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords: cartilage oligomeric matrix protein, matrix metalloproteinase-3, knee osteoarthritis, hip osteoarthritis, osteoarthritis biomarkers, osteoarthritis diagnosis, osteoarthritis progression, serum biomarkers, urinary biomarkers, diagnostic accuracy
MeSH terms: Humans, Peptide Fragments, Prognosis, Osteoarthritis, Hip, Biomarkers, Matrix Metalloproteinase 3, Osteoarthritis, Knee, Collagen Type II, Cartilage Oligomeric Matrix Protein

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Cartilage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip osteoarthritis (OA) diagnosis: a systematic review and meta-analysis

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