Osteoarthritis Year in Review 2024: Molecular biomarkers of osteoarthritis
Open accessAbstract
Objective To provide a comprehensive and insightful summary of studies on molecular biomarkers at the gene, protein, and metabolite levels across different sample types and joints affected by osteoarthritis (OA). Methods A literature search using the PubMed database for publications on OA biomarkers published between April 1, 2023 and April 30, 2024 was performed. Publications were then screened, examined at length, and summarized in a narrative review. Results Out of the 364 papers initially identified, 44 publications met inclusion criteria, were relevant to OA, and were further examined for data extraction and discussion. These studies included 1 genomic analysis, 22 on protein markers, 6 on metabolite markers, 9 on inflammatory mediators, and 6 integrating multiple molecular levels. Conclusions Significant advancements have been made in identifying molecular biomarkers for OA, encompassing various joints, sample types, and molecular levels. Despite this progress, gaps remain, particularly in the need for validation, larger sample sizes, the integration of more clinical data, and consideration of covariates. For early detection and improved treatment of OA, continued efforts in biomarker identification are needed. This effort should seek to identify effective biomarkers that advance early detection, support prevention, evaluate interventions, and improve patient outcomes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
High-throughput screening and single-cell analytics have transformed biomarker discovery for degenerative joint disease by enabling comprehensive molecular profiling across genomic, transcriptomic, proteomic, and metabolomic domains.
“High-throughput screening and single-cell analytics have transformed biomarker discovery for degenerative joint disease by enabling comprehensive molecular profiling across genomic, transcriptomic, proteomic, and metabolomic domains”
From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [155]
The Introduction and Discussion describe osteoarthritis biomarker research at gene, protein, and metabolite levels, and the Concluding Remarks say multi-omic studies show promise. But the copy does not attribute this progress to high-throughput screening or single-cell analytics, nor does it say those methods have transformed discovery or enabled comprehensive profiling across all four named domains. No page numbers were provided for these passages. (LLM, conf=0.84)
Experimental — accuracy not yet measuredLongitudinal studies and standardization efforts enhance the clinical applicability of biomarkers for degenerative joint disease.
“while longitudinal studies and standardization efforts enhance their clinical applicability [155].”
From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [155]
The Discussion (Protein-level; page unavailable) describes a longitudinal study linking baseline biomarkers to later joint changes and their potential prognostic use. The Concluding Remarks (page unavailable) call for independent validation and larger cohorts to advance biomarkers toward clinical use, but do not specifically identify standardization efforts as a means of improving applicability. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Steinmetz, J. D., Culbreth, G. T., Haile, L. M., Rafferty, Q., Lo, J., Fukutaki, K. G., Cruz, J. A., Smith, A. E., Vollset, S. E., Brooks, P., et al. (2023) · The Lancet Rheumatology · doi:10.1016/s2665-9913(23)00163-7 · Cited by 2,278 · see citing works
Biomarker definitions and their applications
Califf, R. M. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370217750088 · Cited by 1,546 · see citing works
The burden of OA-health services and economics
Leifer, V. P., Katz, J. N., & Losina, E. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.05.007 · Cited by 739 · see citing works
Xia, Y., Xia, C., Wu, L., Li, Z., Li, H., & Zhang, J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12031128 · Cited by 503 · see citing works
Osteoarthritis: Diagnosis and Treatment
Sinusas, K. (1961) · BMJ · doi:10.1136/bmj.1.5222.355-a · Cited by 447 · see citing works
10 Economics of osteoarthritis: a global perspective
MARCH, L. M., & Bachmeier, C. J. M. (1997) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(97)80011-8 · Cited by 320 · see citing works
Inflammation in osteoarthritis: the latest progress and ongoing challenges
Knights, A. J., Redding, S. J., & Maerz, T. (2022) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000923 · Cited by 306 · see citing works
Keshishian, H., Burgess, M. W., Specht, H., Wallace, L., Clauser, K. R., Gillette, M. A., & Carr, S. A. (2017) · Nature Protocols · doi:10.1038/nprot.2017.054 · Cited by 190 · see citing works
Nielsen, R. L., Monfeuga, T., Kitchen, R. R., Egerod, L., Leal, L. G., Schreyer, A. T. H., Gade, F. S., Sun, C. W., Helenius, M., Simonsen, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46663-4 · Cited by 96 · see citing works
Osteoarthritis and the Complement Cascade
Silawal, S., Triebel, J., Bertsch, T., & Schulze-Tanzil, G. G. (2018) · Clinical Medicine Insights Arthritis and Musculoskeletal Disorders · doi:10.1177/1179544117751430 · Cited by 91 · see citing works
Threats to scholarly research integrity arising from paper mills: a rapid scoping review
Pérez-Neri, I., Pineda, C., & Sandoval, H. (2022) · Clinical Rheumatology · doi:10.1007/s10067-022-06198-9 · Cited by 70 · see citing works
Styrkársdóttir, U., Lund, S., Saevarsdottir, S., Magnusson, M. I., Gunnarsdottir, K., Norddahl, G., Frigge, M., Ivarsdottir, E. V., Bjornsdottir, G., Hólm, H., et al. (2021) · Arthritis & Rheumatology · doi:10.1002/art.41793 · Cited by 64 · see citing works
An osteoarthritis pathophysiological continuum revealed by molecular biomarkers
Kraus, V. B., Sun, S., Reed, A., Soderblom, E. J., Moseley, M. A., Zhou, K., Jain, V., Arden, N., & Li, Y. (2024) · Science Advances · doi:10.1126/sciadv.adj6814 · Cited by 36 · see citing works
Styrkarsdottir, U., Lund, S. H., Thorleifsson, G., Saevarsdottir, S., Gudbjartsson, D. F., Thorsteinsdottir, U., & Stefansson, K. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42376 · Cited by 34 · see citing works
Amirkhizi, F., Shahraki, S. H., & Rahimlou, M. (2023) · Journal of Health Population and Nutrition · doi:10.1186/s41043-023-00450-x · Cited by 34 · see citing works
Zhang, X., Ma, S., Naz, S. I., Jain, V. K., Soderblom, E. J., Aliferis, C., & Kraus, V. B. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109812 · Cited by 33 · see citing works
Giordano, R., Ghafouri, B., Arendt‐Nielsen, L., & Petersen, K. K. (2023) · Pain · doi:10.1097/j.pain.0000000000003042 · Cited by 31 · see citing works
Can serum MMP-3 diagnose early knee osteoarthritis?
Singh, S. K., Jindal, D., & Khanna, R. (2023) · Journal of Orthopaedics · doi:10.1016/j.jor.2023.02.014 · Cited by 27 · see citing works
Prognostic model to predict the incidence of radiographic knee osteoarthritis
Paz-González, R., Barreiro, V. B., Lourido, L., Calamia, V., Fernández‐Puente, P., Oreiro, N., Ruíz‐Romero, C., & Blanco, F. J. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-225090 · Cited by 24 · see citing works
Zou, M., & Shao, Z. (2024) · Biomolecules · doi:10.3390/biom14030355 · Cited by 23 · see citing works
Relevance of Biomarkers in Serum vs. Synovial Fluid in Patients with Knee Osteoarthritis
Kalogera, S., Jansen, M. P., Bay‐Jensen, A., Frederiksen, P., Karsdal, M. A., Thudium, C. S., & Mastbergen, S. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119483 · Cited by 23 · see citing works
Tarabeih, N., Kalinkovich, A., Shalata, A., Higla, O., & Livshits, G. (2023) · Biomolecules · doi:10.3390/biom13091315 · Cited by 21 · see citing works
Rai, M. F., Cai, L., Zhang, Q., Townsend, R. R., & Brophy, R. H. (2023) · The American Journal of Sports Medicine · doi:10.1177/03635465231169526 · Cited by 20 · see citing works
Serum proteomic biomarkers diagnostic of knee osteoarthritis
Kraus, V. B., Reed, A., Soderblom, E. J., Golightly, Y. M., Nelson, A. E., & Li, Y. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.09.007 · Cited by 19 · see citing works
Mehta, O., Vijay, A., Gohir, S. A., Kelly, T., Zhang, W., Doherty, M., Walsh, D. A., Aithal, G. P., & Valdes, A. M. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.02.023 · Cited by 18 · see citing works
Paz-González, R., Turkiewicz, A., Ali, N., Ruíz‐Romero, C., Blanco, F. J., Englund, M., & Önnerfjord, P. (2023) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2023.100417 · Cited by 18 · see citing works
Matejová, J., Fecskeová, L. K., Slovinská, L., Harvanová, D., Špaková, T., & Janočková, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-47074-z · Cited by 16 · see citing works
Zhou, Q., Liu, J., Xin, L., Hu, Y., & Qi, Y. (2023) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/tygnk6 · Cited by 15 · see citing works
McAlindon, T. E., Hunnicutt, J. L., Roberts, M. B., Haugen, I. K., Schaefer, L. F., Driban, J. B., Lü, B., Duryea, J., Smith, S. E., Booth, S. L., et al. (2024) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.10.011 · Cited by 15 · see citing works
Armitano‐Lago, C., Evans‐Pickett, A., Davis-Wilson, H. C., Munsch, A. E., Longobardi, L., Willcockson, H. H., Schwartz, T. A., Franz, J. R., & Pietrosimone, B. (2024) · Clinical Rheumatology · doi:10.1007/s10067-024-06898-4 · Cited by 14 · see citing works
Serum proteomic panel validated for prediction of knee osteoarthritis progression
Kraus, V. B., Reed, A., Soderblom, E. J., Moseley, M. A., Hsueh, M.-F., Attur, M. G., Samuels, J., Abramson, S. B., & Li, Y. (2023) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2023.100425 · Cited by 13 · see citing works
Rydén, M., Turkiewicz, A., Önnerfjord, P., Tjörnstrand, J., Englund, M., & Ali, N. (2023) · PROTEOMICS · doi:10.1002/pmic.202300040 · Cited by 11 · see citing works
Wang, X., Cai, W., Liu, Y., Lu, Y.-M., Liu, M., Cao, X., & Guo, D. (2023) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-023-07084-4 · Cited by 11 · see citing works
Turnbull, J., Jha, R. R., Barrett, D. A., Valdes, A. M., Alderson, J., Williams, A., Vincent, T. L., Watt, F. E., & Chapman, V. (2024) · The American Journal of Sports Medicine · doi:10.1177/03635465241228209 · Cited by 11 · see citing works
Coppock, J. A., McNulty, A. L., Starr, K. N. P., Holt, A. G., Borack, M. S., Kosinski, A. S., Collins, A. T., Bales, C. W., & DeFrate, L. E. (2023) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2023.100376 · Cited by 10 · see citing works
Immobilization by 21 days of bed rest results in type II collagen degradation in healthy individuals
Liphardt, A., Godonou, E. T., Dreiner, M., Mündermann, A., Taşçılar, K., Djalal, N., Heer, M. A., Schett, G. A., Zaucke, F., & Niehoff, A. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.11.007 · Cited by 10 · see citing works
Tan, Q., Li, F., Zhang, K., Liu, Z., Tian, Y., & Zhu, T. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00584 · Cited by 10 · see citing works
Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis
Ilia, I., Ciordas, P. D., Nițușcă, D., Anton, A., & Marian, C. (2024) · Medicina · doi:10.3390/medicina60040571 · Cited by 10 · see citing works
Goode, A. P., Cleveland, R. J., Kraus, V. B., Taylor, K. A., George, S. Z., Schwartz, T. A., Renner, J. B., Huebner, J. L., Jordan, J. M., & Golightly, Y. M. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.02.005 · Cited by 10 · see citing works
Clarke, E. J., Varela, L., Jenkins, R. E., Lozano−Andrés, E., Cywińska, A., Przewozny, M., van Weeren, P. R., van de Lest, C. H. A., Peffers, M. J., & Wauben, M. H. M. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101635 · Cited by 10 · see citing works
Almalki, A. A., Gharib, A. F., Almehmadi, M. M., Alharthi, A., Alsalmi, O. A., Alsulimani, A. H., Alanazi, R. H., AlWthenani, A. A., Alotaibi, M. A., & AlZaidi, F. T. (2023) · Cureus · doi:10.7759/cureus.48350 · Cited by 9 · see citing works
Turnbull, J., Jha, R. R., Gowler, P. R. W., Ferrands-Bentley, R., Kim, D., Barrett, D. A., Sarmanova, A., Fernandes, G., Doherty, M., Zhang, W., et al. (2024) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2024.04.006 · Cited by 8 · see citing works
Work-related outcomes in individuals with and without lower limb osteoarthritis: an online survey
Alyousef, Y. S., Johnston, V., & Smith, M. D. (2023) · BMC Public Health · doi:10.1186/s12889-023-16723-3 · Cited by 8 · see citing works
Point-of-Care Testing of the MTF1 Osteoarthritis Biomarker Using Phenolphthalein-Soaked Swabs
Park, S. Y., Chae, D., Lee, J. S., Cho, B.-K., & Lee, N. Y. (2023) · Biosensors · doi:10.3390/bios13050535 · Cited by 8 · see citing works
Mai, N. T. T., Hang, N. T., Hanh, D. H., Le, H., Hinh, N. V., Ky, N. D., Tuan, N. M., Tong, H. V., Quan, D. T., & Toàn, N. L. (2023) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2023e12746 · Cited by 7 · see citing works
sCTX II is a better biomarker than sMMP‐3 to identify early knee osteoarthritis
Singh, S. K., Jindal, D., & Khanna, R. (2023) · Journal of Orthopaedic Research® · doi:10.1002/jor.25582 · Cited by 6 · see citing works
Changes in the Serum Metabolome in an Inflammatory Model of Osteoarthritis in Rats
Berenguer, N. I., Sifre, V., Soler, C., Segarra, S., Mateo, A. G. D. C., & Aguado, C. I. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063158 · Cited by 6 · see citing works
Rocchetti, M. T., Bizzoca, D., Moretti, L., Ragni, E., Moretti, F. L., Vicenti, G., Solarino, G., Rizzello, A., Petruzzella, V., Palese, L. L., et al. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13060916 · Cited by 6 · see citing works
Adepu, S., Lord, M., Hugoh, Z., Nyström, S., Hultén, L. M., Abrahamsson‐Aurell, K., Lützelschwab, C. M., & Skiöldebrand, E. (2023) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2023.100354 · Cited by 5 · see citing works
Meehan, R. T., Gill, M. T., Hoffman, E. D., Coeshott, C. M., Galvan, M. D., Wolf, M. L., Amigues, I., Kastsianok, L., Regan, E. A., Crooks, J., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12175541 · Cited by 5 · see citing works
Liu, D., Zhao, Y.-C., Li, H., Yin, L.-J., Chen, J., & Liu, G. (2024) · Journal of Applied Biomedicine · doi:10.32725/jab.2024.001 · Cited by 5 · see citing works
Zhou, R., Zhao, L., Wang, Q., Cheng, Y., Song, M., & Huang, C. (2024) · Disease Markers · doi:10.1155/2024/9936295 · Cited by 5 · see citing works
Liu, F., Su, F., Zhang, T., Liu, R., Liu, N., & Dong, T. (2023) · Medicine · doi:10.1097/md.0000000000034691 · Cited by 5 · see citing works
Andersson, M., Zimmerman, M., Brogren, E., Bergman, S., Strindberg, L., Fryk, E., & Jansson, P. (2024) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2024.100455 · Cited by 5 · see citing works
Serum carboxymethyllysine concentration is associated with erosive hand osteoarthritis
Cambon‐Binder, A., Jaisson, S., Tuffet, S., Courties, A., Eymard, F., Okwieka, A., Gillery, P., Miquel, A., Rousseau, A., Crema, M. D., et al. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.03.006 · Cited by 4 · see citing works
Kumavat, R., Kumar, V. L., & Biswas, S. (2024) · Molecular Biotechnology · doi:10.1007/s12033-023-00983-w · Cited by 2 · see citing works
Flagged first, then by citations
2 of the 58 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [24]Chen X, Xu J, Zhang H, Yu L. A nomogram for predicting osteoarthritis based on serum biomarkers of bone turnover in middle age: A cross-sectional study of PTH and beta-CTx. Medicine (Baltimore) 2023; 102: e33833. 37335703 PMC10194786
Cited by
Sorted by citations
Osteoarthritis: Mechanisms and Therapeutic Advances
Liu, W., Guo, N., Wang, J., & Xu, B. (2025) · MedComm · doi:10.1002/mco2.70290 · Cited by 53 · see citing works
Cai, J., Chen, Z. H., Yang, X., Cai, J., Chen, L., Chen, S., Zou, Y., Zheng, D., & Xu, L. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107865 · Cited by 15 · see citing works
Coleman, L. J., Byrne, J. L., Edwards, S., & O’Hara, R. (2025) · Biologics · doi:10.3390/biologics5030027 · Cited by 12 · see citing works
Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease
Kumar, R., Sporn, K., Borole, A., Khanna, A., Gowda, C., Paladugu, P., Ngo, A., Jagadeesan, R., Zaman, N., & Tavakkoli, A. (2025) · Diagnostics · doi:10.3390/diagnostics15111418 · Cited by 10 · see citing works
“…analytics have transformed biomarker discovery for degenerative joint disease by enabling comprehensive molecular profiling across genomic, transcriptomic, proteomic, and metabolomic domains, while longitudinal studies and standardization efforts enhance their clinical applicability [155].”
He, Q., Liu, L., Hu, X., Lin, L., Song, Z., Xia, Y., Lin, Q., Wei, J., & Li, S. (2025) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s537507 · Cited by 7 · see citing works
Deng, Y., Liu, J., Bamahel, A. S., Zhang, P., Yu, A., Cui, H., Xu, H., & Fang, Y. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116270 · Cited by 7 · see citing works
Advances in heterogeneity and classification of osteoarthritis
Huang, T., 舒建雄, Wu, Z. Z., Li, Z. A., Tuan, R. S., Ding, C., & Lu, Y. (2026) · Bone Research · doi:10.1038/s41413-026-00549-x · Cited by 7 · see citing works
Ao, Y., Xiao, F., Qiu, J., Lyu, J., Luo, W. F., Liufu, Y., & Junxing, Y. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02618-2 · Cited by 5 · see citing works
MMP13 mRNA Expression Level as a Potential Marker for Knee OA Progression—An Observational Study
Baran, K., Czechowska, A., Kopacz, K., Padula, G., Migdalska‐Sęk, M., Tomaszewski, W., Nowak, K., Domżalski, M. E., & Brzeziańska‐Lasota, E. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14041263 · Cited by 5 · see citing works
Keshari, R., Muddala, G., Rajput, A., Balakrishnan, B., Kaur, N., & Srivastava, R. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107796 · Cited by 4 · see citing works
Osteoimmunology and aging — a frontier to explore
Ille, M., Adamopoulos, I. E., Fain, M. J., & Nikolich‐Žugich, J. (2025) · GeroScience · doi:10.1007/s11357-025-01744-0 · Cited by 4 · see citing works
Yang, G., Bi, S., Zhang, X., Zhong, J., & Wu, L. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116612 · Cited by 4 · see citing works
Systemic implications of osteoarthritis: from local degeneration to systemic metabolic Dysregulation
Luo, J., Li, L., Deng, Q., Ji, Z., Wang, C., & Dai, B. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08277-w · Cited by 3 · see citing works
Günaydın, E. B., & Ay, S. (2025) · Indian Journal of Orthopaedics · doi:10.1007/s43465-025-01561-9 · Cited by 2 · see citing works
Liu, W., Wang, D., Venkatesan, J. K., Schmitt, G., Madry, H., & Cucchiarini, M. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.01.008 · Cited by 2 · see citing works
An Exploratory Study for Proteomic‐Based Markers of Joint Pain and Chronic Back Pain
Schillemans, T., Rönnegård, A., Assimes, T. L., Peterson, M., Wändell, P. E., Lind, L., & Ärnlöv, J. (2025) · European Journal of Pain · doi:10.1002/ejp.70158 · Cited by 1 · see citing works
Immunonutritional biomarkers in osteoarthritis: mechanistic insights and prognostic potential
Dan, J., Ding, H., Li, L., & Wu, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1769089 · Cited by 1 · see citing works
Garnero, P., Guillemin, F., Sime, W. N., Gineyts, É., Chapurlat, R. D., & Roux, C. H. (2025) · Lara D. Veeken · doi:10.1093/rheumatology/keaf510
What’s New in Musculoskeletal Basic Science
Bahney, C. S., Stoddart, M. J., Miclau, T., & Marcucio, R. (2025) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.25.01234
Sari, D., Çon, F., Güvendi, M., Yelkenci, H. E., Helvacı, N., Kural, A., Zámocký, M., Kural, C., & Beker, M. Ç. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062862
Nanotechnology in follicle tracking and ovarian stimulation
Tiwari, G., Gadhave, R. V., Metri, S. M., Dev, D., Pawar, S. V., Rajendran, S. P., & Kela, P. R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-41561-6.00014-5
Osteoarthrose – aktueller Stand der Diagnostik und Therapie
Mann, J., Kuipers, J. G., & Arnold, I. (2026) · Aktuelle Rheumatologie · doi:10.1055/a-2727-1653
Wang, D., Li, F., Liu, Y., & Wang, S. (2026) · Modern Rheumatology · doi:10.1093/mr/roag038
Harsányi, Š., Schmiedlova, K., Milosovicova, L., Bernatova, S., Harsanyiova, K., Danišovič, Ľ., & Šteňo, B. (2026) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-026-07009-6
Liu, J., Tang, J., Ma, Z., Wang, Z., & Zhang, H. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s611519
Meng, T., Ma, L., Zhang, X. M., Han, J., Li, F., Wu, W., Liu, S., & Liu, A. (2026) · Human Mutation · doi:10.1155/humu/3061956
Defining the Impact of Genetics on Equine Performance and Development of Orthopaedic Disease
Chernavsky, H., Pezzanite, L. M., Simske, S., & Kawcak, C. E. (2026) · Animals · doi:10.3390/ani16121875
Elmounedi, N., Ellouz, Z., & Keskes, H. (2026) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-026-00607-0
Wytrwał-Sarna, M., Oclon, E. A., Rzepa, S., Pardyak, L., Szmajnta, K., Kucharski, M., Górniewicz, M., & Szczubiałka, K. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127167
Blanco, F. J., Martínez-Sotodosos, L., Oreiro, N., Galindo, L., Vázquez-García, J., Noriega-Cobo, D. M., Lourido, L., Paz-González, R., Quaranta, P., Calamia, V., et al. (2026) · medRxiv · doi:10.64898/2026.07.21.26357764
Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities
Enteshari-Moghaddam, A., Khorramdelazad, H., & Abbasifard, M. (2026) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2026.100395
Liu, H., Yao, D., Wang, Y., & Kong, Q. (2026) · Calcified Tissue International · doi:10.1007/s00223-026-01598-4
Epidemiology and potential mechanisms of structural progression in osteoarthritis
Das, S., Swain, P., Swain, S., Misra, R. D. K., & Rautray, T. R. (2026) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2026.2724794
Li, F., Tan, M., Zhai, R., Ouyang, Y., & Shen, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1938807 · Cited by 1 · see citing works
Kulpinski, J., Carusi, A. T., & Langworthy, M. J. (2026) · Frontiers in Surgery · doi:10.3389/fsurg.2026.1924870
Kim, Y. I., Padalhin, A., Ryu, H. S., Abueva, C. D. G., Bae, J. S., Park, S. Y., Jeon, H. B., Mo, J., Chung, P., Gong, H. S., et al. (2026) · Biomaterials Research · doi:10.34133/bmr.0424
Serum evaluation of synovial fluid biomarkers in osteoarthritis
Yang, L., Wang, B., Wang, J., Ma, Q., & Cheng, Y. (2026) · Journal of orthopaedic surgery · doi:10.1177/10225536261498974
Neural crosstalk between subchondral bone and synovium in osteoarthritis
Feng, Y., Gao, Q., Liu, X., & Li, Y. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1971392
Blees, N. R., Teunissen, M., Smit, I. H., Verseijden, F., Meij, B. P., Prevo-Keijbets, E., van Vuure, C., Corbee, R. J., & Tryfonidou, M. A. (2026) · The Veterinary Journal · doi:10.1016/j.tvjl.2026.106946
- Authors
- Welhaven, H. D., Welfley, A. H., & June, R. K.
- Affiliations
- Montana State University (US)
- Corresponding author
- June, Ronald K.
- Venue
- Osteoarthritis and Cartilage
- Publisher
- Elsevier BV
- Published
- 2025-01
- Volume
- 33
- Issue
- 1
- Pages
- 67-87
- ISSN
- 1063-4584 (ISSN-L)
- PMC
- PMC11663115
- OpenAlex
- W4403528140
- Cited by
- 39
- References
- 58
- Citations by year
- 2026: 26 · 2025: 13
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Osteoarthritis and Cartilage (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Montana State University ScholarWorks (Montana State University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Science Foundation Division of Civil Mechanical and Manufacturing Innovation
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Surgery › Hip disorders and treatments
- Keywords
- osteoarthritis, molecular biomarkers, protein biomarkers, metabolic biomarkers, genomic biomarkers, inflammatory mediators, early detection, biomarker validation, joint diseases
- MeSH terms
- Humans, Osteoarthritis, Biomarkers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
