Psychosis in multiple sclerosis associated with left temporal lobe lesions on serial MRI scans
Abstract
There is retrospective evidence of a correlation between psychosis in multiple sclerosis (MS) patients and temporal lobe pathology. A 35-year-old woman with MS presented with psychosis. There was no concurrent history of medication/substance use or family history. Comparison with previous MRI scans showed significant progression of lesions within the periventricular white matter of the left temporal lobe. This case highlights the association of psychosis and MS progression with worsening of left temporal lobe lesions. Prospective studies are required to ascertain the extent to which left temporal lobe lesions are predictive of future psychosis.
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Increased phasic activity of dopaminergic neurons could drown out dopaminergic activity associated with reinforcing or motivationally salient stimuli, leading to negative symptoms such as anhedonia, avolition, and apathy.
“With respect to the etiology of negative symptoms, it is possible that the increased phasic activity of these dopaminergic neurons could ''drown out'' the dopaminergic activity typically associated with reinforcing or motivationally salient stimuli, as per the suggestion of Roiser et al. 69 The consequently reduced valence of typically reinforcing stimuli could underlie such negative symptoms of”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [70]
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Schizophrenia, myelination, and delayed corollary discharges: a hypothesis
Whitford, T. J., Ford, J. M., Mathalon, D. H., Kubicki, M., & Shenton, M. E. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq105 · Cited by 140 · see citing works
- Authors
- Reiss, J. P., Sam, D., & Sareen, J.
- Affiliations
- University of Manitoba (CA)
- Corresponding author
- Reiss, Jeffrey P.
- ORCID
- Sareen, Jitender
- Venue
- Journal of Clinical Neuroscience
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 13
- Issue
- 2
- Pages
- 282-284
- ISSN
- 0967-5868 (ISSN-L)
- OpenAlex
- W2093780860
- Cited by
- 31
- References
- 8
- Citations by year
- 2024: 1 · 2021: 1 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- psychosis, multiple sclerosis, periventricular white matter lesions, lesion progression, magnetic resonance imaging, psychosis prediction, temporal lobe pathology
- MeSH terms
- Olanzapine, Lamotrigine, Adult, Benzodiazepines, Delusions, Female, Hallucinations, Humans, Magnetic Resonance Imaging, Multiple Sclerosis, Pain, Psychotic Disorders, Temporal Lobe, Antipsychotic Agents, Triazines, Weight Gain, Excitatory Amino Acid Antagonists, Risperidone
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