The Role of Ovarian Volume As a Diagnostic Criterion for Chinese Adolescents with Polycystic Ovary Syndrome
Abstract
Background This study revisited the ovarian volume (OV) as one of the diagnostic criteria for Chinese adolescents with polycystic ovary syndrome (PCOS). It is unknown whether the threshold of 10 cm(3) for the OV, chosen at the PCOS international consensus in 2003, was optimal for Chinese PCOS adolescents or not.Methods 69 adolescent PCOS patients and 26 controls were involved in this study. Ultrasound examination was performed between cycle days 2 and 7 or at random with a 6-MHz transvaginal transducer. Receiver operating characteristic (ROC) curves analysis was mainly used for statistical analysis.Results Mean OV and maximum OV were significantly larger in PCOS group than that in controls. The area under the ROC curve was >0.8 for both criteria, indicating a satisfactory diagnostic potency. The two criteria had no statistical difference in diagnostic potency. Setting the threshold of mean OV at 6.74 cm(3) offered the best compromise between specificity (92.3%) and sensitivity (75.4%) and setting the threshold of maximum OV at 7.82 cm(3) offered the best compromise between specificity (88.5%) and sensitivity (73.9%).Conclusions OV yields good diagnostic accuracy to distinguish normal ovaries from polycystic ovaries in Chinese adolescents, but for Chinese PCOS adolescents, the best compromise between sensitivity and specificity was obtained with a threshold set at 6.74 cm(3) for mean ovarian volume and at 7.82 cm(3) for maximum ovarian volume instead of the 10 cm(3) threshold proposed by the Rotterdam consensus conference based on general PCOS patients.
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One level III3 case-control study with moderate risk of bias was identified by our search to answer the question, and was deemed insufficient evidence on which to base a recommendation.
“One level III3 case-control study with moderate risk of bias 73 was identified by our search to answer the question, and was deemed insufficient evidence on which to base a recommendation.”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [73]
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- Authors
- Chen, Y., Yang, D., Li, L., & Chen, X.
- Affiliations
- Sun Yat-sen University (CN)
- Venue
- Journal of Pediatric and Adolescent Gynecology
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 21
- Issue
- 6
- Pages
- 347-350
- ISSN
- 0932-8610 (ISSN-L)
- 1083-3188
- OpenAlex
- W2035780799
- Cited by
- 34
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2020: 3 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 2 · 2012: 2
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric and Adolescent Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- polycystic ovary syndrome, ovarian volume, adolescents, diagnostic thresholds, diagnostic accuracy, transvaginal ultrasound, Chinese adolescents
- MeSH terms
- Adolescent, China, Female, Humans, Organ Size, Ovary, Polycystic Ovary Syndrome, Sensitivity and Specificity, Ultrasonography
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