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Cited by 5Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and DisordersMenopause: Health Impacts and Treatments

The efficacy of long-term estrogen replacement therapy in Turner syndrome women with premature ovarian insufficiency

Son, Kyung-A, Lee, Dong-Yun, Yoon, Byung-Koo, Choi, DooSeok·2019·Journal of Pediatric and Adolescent Gynecology
DOI 10.1016/j.jpag.2019.05.008
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Abstract

Study objective To evaluate the efficacy of long-term estrogen replacement therapy (ERT) in uterine development and bone mineral density (BMD) of Turner syndrome (TS) women with premature ovarian insufficiency (POI).Design and setting Retrospective study.Participants and interventions Thirty-seven TS women grouped according to ovarian function status: TS women with POI (n = 32), aged 11-26 years, and those with intact ovarian function (IOF; n = 5), aged 13-17 years. TS women with POI underwent ERT.Main outcome measures Changes in uterine length, anterior-posterior (AP) fundal diameter of the uterus, and BMD were assessed. Statistical methods included Mann-Whitney U test and paired t test.Results In TS women with POI, uterine length, AP fundal diameter, and BMD significantly increased after ERT (P < .001). TS women with POI were subdivided into classic (n = 11) and variant (n = 21) types, and there were no significant differences in uterine development and BMD according to types of chromosome. After receiving ERT, AP fundal diameter was significantly longer in classic TS women (P = .034) compared with those with variant type.Conclusion Long-term ERT increased uterine length (before: 4.4 cm; after: 7.2 cm) and AP fundal diameter (before: 0.9 cm; after: 2.4 cm), and improved BMD in TS women with POI. After ERT, in TS women with POI, uterine length, BMD at lumbar 2-4 and femoral neck were similar to those of TS women with IOF. Therefore, TS women with POI can catch up to those with IOF by receiving ERT.

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  • HRT is important for continuing bone mass accrual to reach peak bone mass during the third decade and for further uterine growth and development.

    “During adulthood the aim is to restore the physiological hormonal environment as closely as possible and HRT is important for continuing bone mass accrual to reach peak bone mass during the third decade and for further uterine growth and development.326,327”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [327]

  • No studies have rigorously defined the effect of dose on BMI, height, weight, or lipids.

    “To date, no studies have rigorously defined the effect of dose on BMI, height, weight, or lipids.327-331”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [327]

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Authors
Son, K.-A., Lee, D.-Y., Yoon, B.-K., & Choi, D.
Affiliations
Samsung Medical Center (KR)
Corresponding author
Choi, DooSeok
ORCID
Venue
Journal of Pediatric and Adolescent Gynecology
Publisher
Elsevier BV
Published
2019-10
Volume
32
Issue
5
Pages
530-534
ISSN
  • 0932-8610 (ISSN-L)
  • 1083-3188
DOI
10.1016/j.jpag.2019.05.008
OpenAlex
W2946941323
Cited by
5
References
34
Citations by year
2024: 1 · 2023: 2 · 2021: 2
FWCI
0.30
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Pediatric and Adolescent Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
Turner syndrome, premature ovarian insufficiency, estrogen replacement therapy, uterine development, bone mineral density, uterine length, ovarian function
MeSH terms
Adolescent, Adult, Child, Estrogens, Female, Humans, Middle Aged, Retrospective Studies, Turner Syndrome, Uterus, Bone Density, Estrogen Replacement Therapy, Case-Control Studies, Primary Ovarian Insufficiency, Young Adult

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