Establishment of a pediatric ovarian and testicular cryopreservation program for malignant and non-malignant conditions: the Mayo Clinic experience
Abstract
Study objectives To describe the structure of a pediatric fertility preservation (FP) program and to share safety and patient satisfaction data.Design The FP program operates under prospective research protocols approved by the Mayo Clinic Institutional Review Board (IRB).Setting The FP program is a multidisciplinary effort between pediatric gynecology, reproductive endocrinology, pediatric urology, pediatric surgery, and laboratory medicine.Participants The FP program enrolls patients between 0-17 years of age who have been diagnosed with a fertility-threatening condition and/or are scheduled to undergo gonadotoxic treatment.Interventions FP is offered in the form of ovarian tissue cryopreservation (OTC) and testicular (TTC) tissue cryopreservation.Main outcome measures The outcome measures are the safety of the procedure and results of patient surveys conducted by phone using a standard list of questions to assess attitudes towards FP.Results To date, we have enrolled 38 OTC and 37 TTC patients. The median age (range) of OTC and TTC patients was 11 years (0.83-17 years) and 10 years (0.92-17 years) at the time of enrollment, respectively. Childhood cancers currently represent 88% of the fertility-threatening diagnoses. Meanwhile, patients with non-malignant conditions include those with gender dysphoria, aplastic anemia, and Turner's syndrome. To date, no serious adverse events (SAEs) have been reported following surgery. According to n = 34 one-year follow-ups, 100% of parents felt that FP was a good decision.Conclusion Consistent with the literature, our data suggests FP is safe and improves the quality of care provided to pediatric patients for their fertility-threatening diagnoses and/or treatments.Trial registration NCT02872532, NCT02646384.
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In three of four case reports, follicles were found in cases with a mosaic karyotype.
“Furthermore, in three of four case reports follicles were found in cases with a mosaic karyotype.600,615-617”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [617]
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224 · see citing works
Nadesapillai, S., van der Velden, J., van der Coelen, S., Schleedoorn, M., Sedney, A., Spath, M., Schurink, M., Oerlemans, A., IntHout, J., Beerendonk, I., et al. (2023) · Fertility and Sterility · doi:10.1016/j.fertnstert.2023.08.004 · Cited by 38 · see citing works
- Authors
- Joshi, V. B., Behl, S., Pittock, S. T., Arndt, C. A. S., Zhao, Y., Khan, Z., Granberg, C. F., & Chattha, A.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Chattha, Asma
- Venue
- Journal of Pediatric and Adolescent Gynecology
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 34
- Issue
- 5
- Pages
- 673-680
- ISSN
- 0932-8610 (ISSN-L)
- 1083-3188
- OpenAlex
- W3158052626
- Cited by
- 23
- References
- 61
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 2 · 2021: 2
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric and Adolescent Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- ovarian tissue cryopreservation, testicular tissue cryopreservation, gonadotoxic therapy, childhood cancer, patient safety, patient satisfaction, gender dysphoria, aplastic anemia, Turner syndrome
- MeSH terms
- Child, Female, Humans, Male, Neoplasms, Ovary, Prospective Studies, Testis, Cryopreservation, Fertility Preservation
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