Cited by 2,766Sex and Gender in HealthcarePain Mechanisms and TreatmentsPain Management and Placebo Effect

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Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

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Fillingim, Roger B., King, Christopher D., Ribeiro-Dasilva, Margarete C., Rahim-Williams, Bridgett, Riley, Joseph L.·2009·The Journal of Pain

DOI 10.1016/j.jpain.2008.12.001PMC PMC2677686

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Abstract

Unlabelled Sex-related influences on pain and analgesia have become a topic of tremendous scientific and clinical interest, especially in the last 10 to 15 years. Members of our research group published reviews of this literature more than a decade ago, and the intervening time period has witnessed robust growth in research regarding sex, gender, and pain. Therefore, it seems timely to revisit this literature. Abundant evidence from recent epidemiologic studies clearly demonstrates that women are at substantially greater risk for many clinical pain conditions, and there is some suggestion that postoperative and procedural pain may be more severe among women than men. Consistent with our previous reviews, current human findings regarding sex differences in experimental pain indicate greater pain sensitivity among females compared with males for most pain modalities, including more recently implemented clinically relevant pain models such as temporal summation of pain and intramuscular injection of algesic substances. The evidence regarding sex differences in laboratory measures of endogenous pain modulation is mixed, as are findings from studies using functional brain imaging to ascertain sex differences in pain-related cerebral activation. Also inconsistent are findings regarding sex differences in responses to pharmacologic and non-pharmacologic pain treatments. The article concludes with a discussion of potential biopsychosocial mechanisms that may underlie sex differences in pain, and considerations for future research are discussed.Perspective This article reviews the recent literature regarding sex, gender, and pain. The growing body of evidence that has accumulated in the past 10 to 15 years continues to indicate substantial sex differences in clinical and experimental pain responses, and some evidence suggests that pain treatment responses may differ for women versus men.

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Classification of chronic pain
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Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198
The complex role of estrogens in inflammation
Straub, R. H. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0001 · Cited by 1,950
The Effect of Race and Sex on Physicians' Recommendations for Cardiac Catheterization
Schulman, K. A., Berlin, J. A., Harless, W., Kerner, J. F., Sistrunk, S., Gersh, B. J., Dubé, R., Taleghani, C. K., Burke, J. E., Williams, S., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902253400806 · Cited by 1,934

Show all 463 references

Research works printed but not linked: 3

de Leeuw, 2006, Influence of estrogen on brain activation during stimulation with painful heat, J Oral Maxillofac Surg, 64, 158, 10.1016/j.joms.2005.10.006 · DOI
De, 2008, Preoperative psychologic and demographic predictors of pain perception and tramadol consumption using intravenous patient-controlled analgesia, Clin J Pain, 24, 399, 10.1097/AJP.0b013e3181671a08 · DOI
Fillingim, 1996, The influence of gender and psychological factors on pain perception, J Gender Cult Health, 1, 21

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the VZV Pain Study Group, Parruti, G., Tontodonati, M., Rebuzzi, C., Polilli, E., Sozio, F., Consorte, A., Agostinone, A., Masi, F. D., Congedo, G., et al. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-58 · Cited by 75
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Back and neck pain are related to mental health problems in adolescence
Rees, C. S., Smith, A. J., O’Sullivan, P., Kendall, G. E., & Straker, L. M. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-382 · Cited by 75
Sex differences in pain responses
Sorge, R. E., & Strath, L. J. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.05.006 · Cited by 73
Effects of pain neuroscience education and dry needling for the management of patients with chronic myofascial neck pain: a randomized clinical trial
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Novicoff, W. M., & Saleh, K. J. (2011) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-010-1765-y · Cited by 77
Sex, Gender, and Orofacial Pain
Shaefer, J. R., Khawaja, S. N., & Bavia, P. F. (2018) · Dental Clinics of North America · doi:10.1016/j.cden.2018.06.001 · Cited by 75
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Multifacet assessment of capability for suicide: Development and prospective validation of the Acquired Capability With Rehearsal for Suicide Scale.
George, S. E., Page, A. C., Hooke, G. R., & Stritzke, W. G. K. (2016) · Psychological Assessment · doi:10.1037/pas0000276 · Cited by 73
Listening is therapy: Patient interviewing from a pain science perspective
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Authors: Fillingim, R. B., King, C. D., Ribeiro-Dasilva, M. C., Rahim-Williams, B., & Riley, J. L.
Affiliations: University of Florida (US)
University of Florida Health (US)
Corresponding author: Fillingim, Roger B.
ORCID: Fillingim, Roger B.
King, Christopher D.
Ribeiro-Dasilva, Margarete C.
Rahim-Williams, Bridgett
Riley, Joseph L.
Venue: The Journal of Pain
Publisher: Elsevier BV
Published: 2009-05
Volume: 10
Issue: 5
Pages: 447-485
ISSN: 1526-5900 (ISSN-L)
DOI: 10.1016/j.jpain.2008.12.001
PMC: PMC2677686
OpenAlex: W2000492372
Cited by: 2,766
References: 463
Citations by year: 2026: 149 · 2025: 192 · 2024: 179 · 2023: 161 · 2022: 191 · 2021: 194 · 2020: 216 · 2019: 196 · 2018: 197 · 2017: 156 · 2016: 180 · 2015: 140 · 2014: 148 · 2013: 153 · 2012: 121
FWCI: 13.93
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5246 d)
Locations: Journal of Pain (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS41670, R01NS041670, T32NS045551)
National Institute of Dental and Craniofacial Research (U01DE017018)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: sex differences in pain, gender differences, experimental pain, pain sensitivity, postoperative pain, temporal summation of pain, endogenous pain modulation, biopsychosocial mechanisms, sex hormones
MeSH terms: Adolescent, Analgesics, Animals, Mental Disorders, Child, Female, Hormones, Humans, Male, Pain, Pain Measurement, Sex Characteristics, Social Environment, Pain Management

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Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

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