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Cited by 757Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsMusculoskeletal pain and rehabilitation

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

The Central Sensitization Inventory (CSI): establishing clinically-significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample

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Neblett, Randy, Cohen, Howard, Choi, YunHee, Hartzell, Meredith M., Williams, Mark, Mayer, Tom G., Gatchel, Robert J.·2013·The Journal of Pain
DOI 10.1016/j.jpain.2012.11.012PMC PMC3644381
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Abstract

Unlabelled Central sensitization (CS) is a proposed physiological phenomenon in which central nervous system neurons become hyperexcitable, resulting in hypersensitivity to both noxious and non-noxious stimuli. The term central sensitivity syndrome (CSS) describes a group of medically indistinct (or nonspecific) disorders, such as fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome, for which CS may be a common etiology. In a previous study, the Central Sensitization Inventory (CSI) was introduced as a screening instrument for clinicians to help identify patients with a CSS. It was found to have high reliability and validity (test-retest reliability = .82; Cronbach's alpha = .88). The present study investigated a cohort of 121 patients who were referred to a multidisciplinary pain center, which specializes in the assessment and treatment of complex pain and psychophysiological disorders, including CSSs. A large percentage of patients (n = 89, 74%) met clinical criteria for one or more CSSs, and CSI scores were positively correlated with the number of diagnosed CSSs. A receiver operating characteristic analysis determined that a CSI score of 40 out of 100 best distinguished between the CSS patient group and a nonpatient comparison sample (N = 129) (area under the curve = .86, sensitivity = 81%, specificity = 75%).Perspective The CSI is a new self-report screening instrument to help identify patients with CSSs, including fibromyalgia. The present study investigated CSI scores in a heterogeneous pain population with a large percentage of CSSs, and a normative nonclinical sample to determine a clinically relevant cutoff value.

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Research works printed but not linked: 3

  1. American Psychiatric Association: Diagnostic and statistical manual of mental disorders, 4th edition, text rev. American Psychiatric Association, Washington, D.C., 2000
  2. Yunus, 2000, Central Sensitivity Syndromes: A Unified Concept for Fibromyalgia and other Similar Maladies, J Indian Rheum Assoc, 8, 27
  3. Zhu W, Zeng N: Sensitivity, specificity, accuracy, associated confidence interval and ROC analysis with practical SAS Implementations. Available at: http://www.nesug.org/Proceedings/nesug10/hl/hl07.pdf. Accessed May 9, 2012

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Metadata

Authors
Neblett, R., Cohen, H., Choi, Y., Hartzell, M. M., Williams, M., Mayer, T. G., & Gatchel, R. J.
Affiliations
  • Productive Rehabilitation Institute of Dallas for Ergonomics (US)
  • The University of Texas at Arlington (US)
  • The University of Texas Southwestern Medical Center (US)
Corresponding author
Mayer, Tom G.
ORCID
Venue
The Journal of Pain
Publisher
Elsevier BV
Published
2013-05
Volume
14
Issue
5
Pages
438-445
ISSN
1526-5900 (ISSN-L)
DOI
10.1016/j.jpain.2012.11.012
PMC
PMC3644381
OpenAlex
W1976214008
Cited by
757
References
45
Citations by year
2026: 90 · 2025: 88 · 2024: 82 · 2023: 99 · 2022: 87 · 2021: 83 · 2020: 58 · 2019: 49 · 2018: 39 · 2017: 31 · 2016: 23 · 2015: 17 · 2014: 7 · 2013: 3
FWCI
11.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Pain (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Public Health Service (1UO1 DEO10713-12A2)
  • National Institute of Dental and Craniofacial Research (U01DE010713)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords
Central Sensitization Inventory, central sensitization, central sensitivity syndromes, fibromyalgia, chronic pain, screening tool, cut-off values, receiver operating characteristic, reference values, multidisciplinary pain center, complex pain
MeSH terms
Adolescent, Adult, Female, Fibromyalgia, Humans, Male, Middle Aged, Outpatients, ROC Curve, Sensitivity and Specificity, Cohort Studies, Young Adult, Central Nervous System Sensitization, Chronic Pain

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