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Cited by 528Temporomandibular Joint DisordersPsychosomatic Disorders and Their TreatmentsMusculoskeletal pain and rehabilitation

The DOI matches its Crossref record; 92 of the 93 references it cites were found in a registry or an index.

Psychological Factors Associated With Development of TMD: The OPPERA Prospective Cohort Study

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Fillingim, Roger B., Ohrbach, Richard, Greenspan, Joel D., Knott, Charles, Diatchenko, Luda, Dubner, Ronald, Bair, Eric, Baraian, Cristina, Mack, Nicole, Slade, Gary D., Maixner, William·2013·The Journal of Pain
DOI 10.1016/j.jpain.2013.06.009PMC PMC3855656
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Abstract

Unlabelled Case-control studies have consistently associated psychological factors with chronic pain in general and with temporomandibular disorder (TMD) specifically. However, only a handful of prospective studies have explored whether preexisting psychological characteristics represent risk factors for first-onset TMD. The current findings derive from the prospective cohort study of the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) cooperative agreement. For this study, 3,263 TMD-free participants completed a battery of psychological instruments assessing general psychological adjustment and personality, affective distress, psychosocial stress, somatic symptoms, and pain coping and catastrophizing. Study participants were then followed prospectively for an average of 2.8 years to ascertain cases of first-onset of TMD, and 2,737 provided follow-up data and were considered in the analyses of TMD onset. In bivariate and demographically adjusted analyses, several psychological variables predicted increased risk of first-onset TMD, including reported somatic symptoms, psychosocial stress, and affective distress. Principal component analysis of 26 psychological scores was used to identify latent constructs, revealing 4 components: stress and negative affectivity, global psychological and somatic symptoms, passive pain coping, and active pain coping. In multivariable analyses, global psychological and somatic symptoms emerged as the most robust risk factor for incident TMD. These findings provide evidence that measures of psychological functioning can predict first onset of TMD. Future analyses in the OPPERA cohort will determine whether these psychological factors interact with other variables to increase risk for TMD onset and persistence.Perspective This article reports that several premorbid psychological variables predict first-onset TMD in the OPPERA study, a large prospective cohort study designed to discover causal determinants of TMD pain. Measures of somatic symptoms were most strongly associated with TMD onset, but perceived stress, previous life events, and negative affect also predicted TMD incidence.

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Research works printed but not linked: 2

  1. Adams J: A computer experiment to evaluate regression strategies. Proceedings of the American Statistical Association Section on Statistical Computing, 1991
  2. Dworkin, 1992, Research diagnostic criteria for temporomandibular disorders, J Craniomandib Disord, 6, 302

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Metadata

Authors
Fillingim, R. B., Ohrbach, R., Greenspan, J. D., Knott, C., Diatchenko, L., Dubner, R., Bair, E., Baraian, C., Mack, N., Slade, G. D., & Maixner, W.
Affiliations
  • University of Florida Health (US)
  • University at Buffalo, State University of New York (US)
  • University of Maryland, Baltimore (US)
  • Battelle (US)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Fillingim, Roger B.
ORCID
Venue
The Journal of Pain
Publisher
Elsevier BV
Published
2013-12
Volume
14
Issue
12
Pages
T75-T90
ISSN
1526-5900 (ISSN-L)
DOI
10.1016/j.jpain.2013.06.009
PMC
PMC3855656
OpenAlex
W2001391699
Cited by
528
References
93
Citations by year
2026: 45 · 2025: 62 · 2024: 65 · 2023: 52 · 2022: 69 · 2021: 48 · 2020: 42 · 2019: 30 · 2018: 41 · 2017: 21 · 2016: 22 · 2015: 14 · 2014: 7 · 2013: 5
FWCI
26.10
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Pain (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • National Institutes of Health
  • University at Buffalo
  • National Institute of Dental and Craniofacial Research (U01DE017018)
Topics
  • Health Sciences › Dentistry › Oral Surgery › Temporomandibular Joint Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords
temporomandibular disorders, psychological risk factors, somatic symptoms, psychosocial stress, emotional distress, negative affectivity, pain coping, pain catastrophizing, psychological adjustment, personality, orofacial pain
MeSH terms
Adolescent, Adult, Facial Pain, Female, Humans, Male, Prospective Studies, Surveys and Questionnaires, Risk Factors, Temporomandibular Joint Disorders

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