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Cited by 323

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Summary of Findings From the OPPERA Prospective Cohort Study of Incidence of First-Onset Temporomandibular Disorder: Implications and Future Directions

Open access
Slade, Gary D., Fillingim, Roger B., Sanders, Anne E., Bair, Eric, Greenspan, Joel D., Ohrbach, Richard, Dubner, Ronald, Diatchenko, Luda, Smith, Shad B., Knott, Charles, Maixner, William·2013·The Journal of Pain
DOI 10.1016/j.jpain.2013.09.010
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Abstract

Papers in this volume investigate when and how putative risk factors influence development of first-onset, painful temporomandibular disorders (TMD). The results represent first findings from the OPPERA prospective cohort study which monitored 2,737 men and women aged 18–44 years recruited at four U.S. study sites. During a median 2.8 year follow-up period, 260 participants developed TMD. The average incidence rate of 4% per annum was influenced by a broad range of phenotypic risk factors including sociodemographic characteristics, health status, clinical orofacial factors, psychological functioning, pain sensitivity and cardiac autonomic responses. A novel method of multivariable analysis used random forest models to simultaneously evaluate contributions of all 202 phenotypic variables. Variables from the health status domain made the greatest contribution to TMD incidence, followed closely by psychological and clinical orofacial domains. However, only a few measures of pain sensitivity and autonomic function contributed to TMD incidence, and their effects were modest. Meanwhile, age and study site were independent predictors of TMD incidence, even after controlling for other phenotypes. Separate analysis of 358 genes that regulate pain found several novel genetic associations with intermediate phenotypes which, themselves, are risk factors for TMD, suggesting new avenues to investigate biological pathways contributing to TMD.

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Metadata

Authors
Slade, G. D., Fillingim, R. B., Sanders, A. E., Bair, E., Greenspan, J. D., Ohrbach, R., Dubner, R., Diatchenko, L., Smith, S. B., Knott, C., & Maixner, W.
Venue
The Journal of Pain
Publisher
Elsevier BV
Published
2013-12
Volume
14
Issue
12
Pages
T116-T124
ISSN
1526-5900 (ISSN-L)
DOI
10.1016/j.jpain.2013.09.010
OpenAlex
W2066700516
Cited by
323
References
23
FWCI
19.92
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Summary of Findings From the OPPERA Prospective Cohort Study of Incidence of First-Onset Temporomandibular Disorder: Implications and Future Directions. https://app.cochat.ai/papers/10.1016/j.jpain.2013.09.010
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Slade, G. D., Fillingim, R. B., Sanders, A. E., Bair, E., Greenspan, J. D., Ohrbach, R., Dubner, R., Diatchenko, L., Smith, S. B., Knott, C., & Maixner, W. (2013). Summary of Findings From the OPPERA Prospective Cohort Study of Incidence of First-Onset Temporomandibular Disorder: Implications and Future Directions. The Journal of Pain. https://doi.org/10.1016/j.jpain.2013.09.010

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.