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Cited by 126Temporomandibular Joint DisordersMusculoskeletal pain and rehabilitationPsychosomatic Disorders and Their Treatments

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Long-term changes in biopsychosocial characteristics related to temporomandibular disorder: findings from the OPPERA study

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Fillingim, Roger B., Slade, Gary D., Greenspan, Joel D., Dubner, Ronald, Maixner, William, Bair, Eric, Ohrbach, Richard·2018·Pain
DOI 10.1097/j.pain.0000000000001348PMC PMC6193833
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Abstract

Painful temporomandibular disorders (TMDs) are both consequence and cause of change in multiple clinical, psychosocial, and biological factors. Although longitudinal studies have identified antecedent biopsychosocial factors that increase risk of the TMD onset and persistence, little is known about long-term change in those factors after TMD develops or remits. During a 7.6-year median follow-up period, we measured change in psychosocial characteristics, pain sensitivity, cardiovascular indicators of autonomic function, and clinical jaw function among 189 participants whose baseline chronic TMD status either persisted or remitted and 505 initially TMD-free participants, 83 of whom developed TMD. Among initially TMD-free participants who developed TMD, symptoms and pain sensitivity increased, whereas psychological function worsened. By contrast, participants with chronic TMD at baseline tended to show improved TMD symptoms, improved jaw function, reduced somatic symptoms, and increased positive affect. In general, clinical and psychosocial variables more frequently changed in parallel with TMD status compared with pain sensitivity and autonomic measures. These findings demonstrate a complex pattern of considerable changes in biopsychosocial function associated with changes in TMD status. In particular, several biopsychosocial parameters improved among participants with chronic TMD despite pain persisting for years, suggesting considerable potential for ongoing coping and adaptation in response to persistent pain.

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Metadata

Authors
Fillingim, R. B., Slade, G. D., Greenspan, J. D., Dubner, R., Maixner, W., Bair, E., & Ohrbach, R.
Affiliations
  • University of Florida (US)
  • University of North Carolina at Chapel Hill (US)
  • University of Maryland, Baltimore (US)
  • Duke University (US)
  • University at Buffalo, State University of New York (US)
Corresponding author
Fillingim, Roger B.
ORCID
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-07-18
Volume
159
Issue
11
Pages
2403-2413
ISSN
  • 0304-3959 (ISSN-L)
  • 1872-6623
DOI
10.1097/j.pain.0000000000001348
PMC
PMC6193833
OpenAlex
W2884836766
Cited by
126
References
7
Citations by year
2026: 13 · 2025: 23 · 2024: 20 · 2023: 15 · 2022: 15 · 2021: 15 · 2020: 21 · 2019: 4
FWCI
16.04
Type
journal article
Language
en
Open access
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (UL1TR001427)
  • National Institute on Aging (P30AG028740)
  • National Institute of Dental and Craniofacial Research (U01DE017018)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Dentistry › Oral Surgery › Temporomandibular Joint Disorders
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
temporomandibular disorders, chronic pain, biopsychosocial factors, pain sensitivity, autonomic function, jaw function, psychological functioning, somatic symptoms, positive affect, coping and adaptation, long-term trends
MeSH terms
Adult, Cardiovascular Physiological Phenomena, Female, Health Status, Humans, Male, Middle Aged, Pain Measurement, Surveys and Questionnaires, Risk Factors, Severity of Illness Index, Social Behavior, Temporomandibular Joint Disorders, Cohort Studies, Pain Threshold, Risk Assessment, Biophysical Phenomena

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