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Cited by 382

The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.

Mechanisms of Exercise-Induced Hypoalgesia

Open access
Koltyn, Kelli F., Brellenthin, Angelique G., Cook, Dane B., Sehgal, Nalini, Hillard, Cecilia·2014·The Journal of Pain
DOI 10.1016/j.jpain.2014.09.006
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Abstract

The purpose of this study was to examine opioid and endocannabinoid mechanisms of exercise-induced hypoalgesia (EIH). Fifty-eight men and women (mean age = 21 yrs) completed three sessions. During the first session, participants were familiarized with the temporal summation of heat pain and pressure pain protocols. In the exercise sessions, following double-blind administration of either an opioid antagonist (50 mg naltrexone) or placebo, participants rated the intensity of heat pulses and indicated their pressure pain thresholds (PPT) and ratings (PPR) before and after 3 minutes of submaximal isometric exercise. Blood was drawn before and after exercise. Results indicated circulating concentrations of two endocannabinoids, N-arachidonylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) as well as related lipids oleoylethanolamide (OEA), palmitoylethanolamide (PEA), N-docsahexaenoylethanolamine (DHEA), and 2-oleoylglycerol (2-OG) increased significantly (p < 0.05) following exercise. PPT increased significantly (p < 0.05) while PPR decreased significantly (p < 0.05) following exercise. Also, temporal summation ratings were significantly lower (p < 0.05) following exercise. These changes in pain responses did not differ between placebo or naltrexone conditions (p > 0.05). A significant association was found between EIH and DHEA. These results suggest involvement of a non-opioid mechanism in EIH following isometric exercise.

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Metadata

Authors
Koltyn, K. F., Brellenthin, A. G., Cook, D. B., Sehgal, N., & Hillard, C.
Venue
The Journal of Pain
Publisher
Elsevier BV
Published
2014-12
Volume
15
Issue
12
Pages
1294-1304
ISSN
1526-5900 (ISSN-L)
DOI
10.1016/j.jpain.2014.09.006
OpenAlex
W2172206302
Cited by
382
References
84
FWCI
10.11
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Mechanisms of Exercise-Induced Hypoalgesia. https://app.cochat.ai/papers/10.1016/j.jpain.2014.09.006
The paper
Koltyn, K. F., Brellenthin, A. G., Cook, D. B., Sehgal, N., & Hillard, C. (2014). Mechanisms of Exercise-Induced Hypoalgesia. The Journal of Pain. https://doi.org/10.1016/j.jpain.2014.09.006

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.