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A Comparison of Symptom Prevalence in Far Advanced Cancer, AIDS, Heart Disease, Chronic Obstructive Pulmonary Disease and Renal Disease
Open accessAbstract
Little attention has been paid to the symptom management needs of patients with life-threatening diseases other than cancer. In this study, we aimed to determine to what extent patients with progressive chronic diseases have similar symptom profiles. A systematic search of medical databases (MEDLINE, EMBASE, and PsycINFO) and textbooks identified 64 original studies reporting the prevalence of 11 common symptoms among end-stage patients with cancer, acquired immunodeficiency syndrome (AIDS), heart disease, chronic obstructive pulmonary disease, or renal disease. Analyzing the data in a comparative table (a grid), we found that the prevalence of the 11 symptoms was often widely but homogeneously spread across the five diseases. Three symptoms-pain, breathlessness, and fatigue-were found among more than 50% of patients, for all five diseases. There appears to be a common pathway toward death for malignant and nonmalignant diseases. The designs of symptom prevalence studies need to be improved because of methodological disparities in symptom assessment and designs.
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“The symptom burden for CHF patients has been likened to those with advanced cancer or acquired immune deficiency syndrome, 6 , 12”
From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [12]
In the citing paper
“Estimates of prevalence of anxiety and depression in COPD vary widely but are generally higher than those reported in some other advanced chronic diseases.”
From Anxiety and Depression in COPD (2008) · cites this paper as [32]
In the citing paper
“In a systematic review32 of 64 studies that focused on patients with severe disease, the prevalence of depression ranged from 37 to 71%, and that of anxiety from 50 to 75%”
From Anxiety and Depression in COPD (2008) · cites this paper as [32]
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“figures comparable to or higher than prevalence rates in other advanced diseases such as cancer, AIDS, heart disease, and renal disease.”
From Anxiety and Depression in COPD (2008) · cites this paper as [32]
In the citing paper
“In a systematic review32 of 64 studies that focused on patients with severe disease, the prevalence of depression ranged from 37 to 71%, and that of anxiety from 50 to 75%”
From Anxiety and Depression in COPD (2008) · cites this paper as [32]
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Liu, X., Zhao, Z., Zhang, Y., Zou, J., & Zhang, L. (2025) · Biomolecules · doi:10.3390/biom15101476 · Cited by 2
Hui, D., Kim, M. J., Thomas, S., Sachdev, G., Shete, S. S., Rathi, N. K., Hensch, N. R., Cruz, V. D. L., Ontai, A., Mahler, D. A., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0336691 · Cited by 1
Metadata
- Authors
- Solano, J. P., Gomes, B., & Higginson, I. J.
- Affiliations
- King's College London (GB)
- Corresponding author
- Higginson, Irene J.
- ORCID
- Higginson, Irene J.
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 31
- Issue
- 1
- Pages
- 58-69
- ISSN
- 0885-3924 (ISSN-L)
- OpenAlex
- W2144048086
- Cited by
- 1,191
- References
- 126
- Citations by year
- 2026: 26 · 2025: 49 · 2024: 52 · 2023: 52 · 2022: 51 · 2021: 67 · 2020: 79 · 2019: 67 · 2018: 72 · 2017: 84 · 2016: 75 · 2015: 77 · 2014: 65 · 2013: 60 · 2012: 74
- FWCI
- 39.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- symptom prevalence, symptom management, cancer, AIDS, heart disease, chronic obstructive pulmonary disease, kidney disease, pain, dyspnea, fatigue, symptom assessment
- MeSH terms
- Acquired Immunodeficiency Syndrome, Aged, Aged, 80 and over, Depression, Female, Heart Diseases, Humans, Kidney Diseases, Male, Middle Aged, Neoplasms, Palliative Care, Pulmonary Disease, Chronic Obstructive
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