The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents
Abstract
Objectives To compare insulin sensitivity and pancreatic beta-cell function measured by the euglycemic and the hyperglycemic clamp, with simple estimates of insulin sensitivity and pancreatic beta-cell function in youth. Study design We measured insulin sensitivity with a euglycemic clamp and first- and second-phase insulin secretion with a hyperglycemic clamp in 156 AA and white youths. Estimates of insulin sensitivity (fasting insulin level [I(F)], the ratio of fasting glucose [G(F)] to I(F) [G(F)/I(F)], homeostasis model assessment estimate of insulin sensitivity [HOMA IS], and quantitative insulin sensitivity check index [QUICKI]) and estimates of pancreatic beta-cell function (I(F), the ratio of I(F) to G(F) [I(F)/G(F)], and homeostasis model assessment estimate of pancreatic beta-cell function [HOMA %B]) were derived from fasting measurements.Results In the total group, IS(Eu) correlated strongly with I(F) (r=-0.92), G(F)/I(F) (r=0.92), HOMA IS (r=0.91), and QUICKI (r=0.91) (P<.01). First-phase and second-phase insulin secretion correlated with I(F), I(F)/G(F), and HOMA %B (first-phase insulin secretion: r=0.76, 0.79, 0.82; second-phase insulin secretion: r=0.83, 0.86, 0.86, respectively; P<.01).Conclusions Simple estimates of insulin sensitivity and pancreatic beta-cell function using fasting insulin and glucose levels serve as surrogate measures of insulin sensitivity and secretion in nondiabetic youths. The validity of these conclusions in children with impaired glucose tolerance and type 2 diabetes mellitus remains to be determined.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Morning 17-OHP values >200 ng/dl appear to detect most adult women with NCAH [108,109]”
From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [109]
Citations
Cites
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Beckett, A. H., Rowland, M., & TURNER, P. (1965) · The Lancet · doi:10.1016/s0140-6736(65)91037-8 · Cited by 16,917
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6661 · Cited by 3,931
Bonora, E., Targher, G., Alberiche, M., Bonadonna, R. C., Saggiani, F., Zenere, M. B., Monauni, T., & Muggeo, M. (2000) · Diabetes Care · doi:10.2337/diacare.23.1.57 · Cited by 2,456
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
Type 2 diabetes among North adolescents: An epidemiologic health perspective
Fagot‐Campagna, A., Pettitt, D. J., Engelgau, M. M., Burrows, N. R., Geiss, L. S., Valdez, R. A., Beckles, G. L., SAADDINE, J. B., Gregg, E. W., Williamson, D. F., et al. (2000) · The Journal of Pediatrics · doi:10.1067/mpd.2000.105141 · Cited by 1,123
Impaired Insulin Action in Puberty
Amiel, S. A., Sherwin, R. S., Simonson, D. C., Lauritano, A. A., & Tamborlane, W. V. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150402 · Cited by 960
Insulin resistance during puberty: results from clamp studies in 357 children.
Moran, A., Jacobs, D. R., Steinberger, J., Hong, C. P., Prineas, R. J., Luepker, R. V., & Sinaiko, A. R. (1999) · Diabetes · doi:10.2337/diabetes.48.10.2039 · Cited by 869
Cited by
Sorted by citations
The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113
Self-citationBoney, C. M., Verma, A., Tucker, R., & Vohr, B. R. (2005) · Pediatrics · doi:10.1542/peds.2004-1808 · Cited by 2,303
Keskin, M., Kurtoğlu, S., Kendırcı, M., Atabek, M. E., & Yazıcı, C. (2005) · PEDIATRICS · doi:10.1542/peds.2004-1921 · Cited by 1,089
August, G. P., Caprio, S., Fennoy, I., Freemark, M., KAUFMAN, F. R., Lustig, R. H., Silverstein, J. H., Speiser, P., Styne, D. M., & Montori, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2458 · Cited by 518
McCormack, S. E., Shaham, O., McCarthy, M. A., Deik, A., Wang, T. J., Gerszten, R. E., Clish, C. B., Mootha, V. K., Grinspoon, S. K., & Fleischman, A. (2012) · Pediatric Obesity · doi:10.1111/j.2047-6310.2012.00087.x · Cited by 453
Metadata
- Authors
- Gungor, N., Saad, R., Janosky, J., & Arslanian, S.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Arslanian, Silva
- ORCID
- Arslanian, Silva
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 144
- Issue
- 1
- Pages
- 47-55
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2035586426
- Cited by
- 457
- References
- 38
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 14 · 2021: 12 · 2020: 15 · 2019: 21 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 16 · 2014: 27 · 2013: 29 · 2012: 25
- FWCI
- 35.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (M01-RR-00084, M01RR000084)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01‐HD27503, R01HD027503, K24HD001357, K24 HD1357)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- insulin sensitivity, insulin secretion, beta-cell function, surrogate measures, euglycemic clamp, hyperglycemic clamp, HOMA-IR, QUICKI, fasting insulin, fasting blood glucose, children and adolescents, type 2 diabetes, impaired glucose tolerance
- MeSH terms
- Adolescent, Blood Glucose, Child, Fasting, Female, Homeostasis, Humans, Insulin, Insulin Resistance, Islets of Langerhans, Male, Obesity, Polycystic Ovary Syndrome, Reproducibility of Results, Glucose Clamp Technique, Linear Models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
