Treatment of familial male-limited precocious puberty with bicalutamide and anastrozole

Kreher, Nerissa C.; Pescovitz, Ora Hirsch; Delameter, Paul; Tiulpakov, Anatoly; Hochberg, Ze’ev

doi:10.1016/j.jpeds.2006.04.027

Cited by 59Hypothalamic control of reproductive hormonesSexual Differentiation and DisordersHormonal and reproductive studies

Treatment of familial male-limited precocious puberty with bicalutamide and anastrozole

Kreher, Nerissa C., Pescovitz, Ora Hirsch, Delameter, Paul, Tiulpakov, Anatoly, Hochberg, Ze’ev·2006·The Journal of Pediatrics

DOI 10.1016/j.jpeds.2006.04.027

Open this paper in CoChat — free account

Abstract

This report describes the use of bicalutamide and anastrozole in two subjects with familial male-limited precocious puberty. Clinical improvements include decreased facial acne and pubic hair. Most importantly, a marked decrease in growth velocity and skeletal advancement has been achieved.

Integrity signals

Registry

Crossref · 10.1016/j.jpeds.2006.04.027

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Earlier studies using tamoxifen or clomifene to increase FSH levels did not show unequivocal evidence for the efficacy of this approach.
“Earlier studies using tamoxifen or clomifene to increase FSH levels did not show unequivocal evidence for the efficacy of this approach [48].”
From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [48]

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471 · see citing works
Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
Morishima, A., Grumbach, M. M., Simpson, E. R., Fisher, C., & Qin, K. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530621 · Cited by 1,416 · see citing works
Tables for predicting adult height from skeletal age: Revised for use with the greulich-pyle hand standards
Bayley, N., & Pinneau, S. R. (1952) · The Journal of Pediatrics · doi:10.1016/s0022-3476(52)80205-7 · Cited by 1,202 · see citing works
Aromatase Inhibition in the Human Male Reveals a Hypothalamic Site of Estrogen Feedback
Hayes, F. J., Seminara, S. B., DeCruz, S., Boepple, P. A., & Crowley, W. F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6795 · Cited by 264 · see citing works
Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty.
Laue, L., Chan, W., Hsueh, A. J. W., 工藤, 正., Hsu, S. Y., Wu, S. M., Blomberg, L. A., & Cutler, G. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.1906 · Cited by 248 · see citing works
Site of Action of Low Dose Ketoconazole on Androgen Biosynthesis in Men*
Santen, R. J., den Bossche, H. V., Symoens, J., Brugmans, J., & DECOSTER, R. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-4-732 · Cited by 230 · see citing works
Estrogen Suppression in Males: Metabolic Effects1
Mauras, N., O'Brien, K. O., Klein, K. O., & Hayes, V. Y. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6676 · Cited by 201 · see citing works
Hepatic reactions during ketoconazole treatment
Janssen, P. A. J., & Symoens, J. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)90519-3 · Cited by 157 · see citing works
Testicular Leydig Cell Hyperplasia as a Cause of Familial Sexual Precocity*
Schedewie, H., Reiter, E. O., Beitins, I. Z., SEYED, S., WOOTEN, V. D., Jimenez, J. F., Aiman, E. J., DeVane, G. W., Redman, J. F., & Elders, M. J. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-2-271 · Cited by 126 · see citing works
Gonadotropin-Independent Familial Sexual Precocity with Premature Leydig and Germinal Cell Maturation (Familial Testotoxicosis): Effects of a Potent Luteinizing Hormone-Releasing Factor Agonist and Medroxyprogesterone Acetate Therapy in Four Cases*
Rosenthal, S. M., Grumbach, M. M., & Kaplan, S. L. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-3-571 · Cited by 121 · see citing works
Estrogen Suppression in Males: Metabolic Effects
Mauras, N. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.7.2370 · Cited by 107 · see citing works
Puberty without Gonadotropins
Wierman, M. E., BEARDSWORTH, D. E., Mansfield, M. J., Badger, T. M., Crawford, J. D., Crigler, J. F., Bode, H. H., Loughlin, J. S., Kushner, D. C., Scully, R. E., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501103120201 · Cited by 91 · see citing works
Bicalutamide (Casodex®) in the treatment of prostate cancer
Fradet, Y. (2004) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.4.1.37 · Cited by 89 · see citing works
Six-Year Results of Spironolactone and Testolactone Treatment of Familial Male-Limited Precocious Puberty with Addition of Deslorelin after Central Puberty Onset
Leschek, E., Jones, J. M., Barnes, K. M., Hill, S. C., & Cutler, G. B. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5413 · Cited by 87 · see citing works
A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty
Yano, K., Saji, M., Hidaka, A., Moriya, N., Okuno, A., Kohn, L. D., & Cutler, G. B. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.4.1162 · Cited by 86 · see citing works
Worldwide activity and safety of bicalutamide: a summary review
Kolvenbag, G. J. C. M., & Blackledge, G. R. P. (1996) · Urology · doi:10.1016/s0090-4295(96)80012-4 · Cited by 69 · see citing works
Gonadotropin-Independent Precocious Puberty Due to Luteinizing Hormone Receptor Mutations in Brazilian Boys: A Novel Constitutively Activating Mutation in the First Transmembrane Helix1
Latronico, A. C., Shinozaki, H., Guerra‐Júnior, G., Pereira, M. A. A., de Lemos‐Marini, S. H. V., Baptista, M. T. M., Arnhold, I. J. P., Fanelli, F., Mendonca, B. B., & Segaloff, D. L. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7071 · Cited by 60 · see citing works
A new point mutation in the luteinising hormone receptor gene in familial and sporadic male limited precocious puberty: genotype does not always correlate with phenotype.
Evans, B. A., Bowen, D. J., Smith, P. J., Clayton, P., & Gregory, J. W. (1996) · Journal of Medical Genetics · doi:10.1136/jmg.33.2.143 · Cited by 59 · see citing works
Gonadotropin-lndependent Precocious Puberty
Holland, F. J. (1991) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30288-3 · Cited by 55 · see citing works
An Open Label 12-Month Pilot Trial on the Effects of the Aromatase Inhibitor Anastrozole in Growth Hormone (GH)-Treated GH Deficient Adolescent Boys
Mauras, N., Welch, S., Rini, A., & Klein, K. O. (2004) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2004.17.12.1597 · Cited by 53 · see citing works
Activating Mutations of the Lutropin Choriogonadotropin Receptor in Precocious Puberty
Shenker, A. (2002) · Receptors and Channels · doi:10.1080/10606820212138 · Cited by 52 · see citing works
Severe testotoxicosis phenotype associated with Asp578-->Tyr mutation of the lutrophin/choriogonadotrophin receptor gene.
Müller, J., Gondos, B., Kosugi, S., Mori, T., & Shenker, A. (1998) · Journal of Medical Genetics · doi:10.1136/jmg.35.4.340 · Cited by 51 · see citing works
Gonadotropin-Independent Precocious Puberty Due to Luteinizing Hormone Receptor Mutations in Brazilian Boys: A Novel Constitutively Activating Mutation in the First Transmembrane Helix
Latronico, A. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.12.4799 · Cited by 48 · see citing works
Treatment of Pubertal Gynecomastia with the Specific Aromatase Inhibitor Anastrozole
Riepe, F. G., Baus, I., Wiest, S., Krone, N. P., Sippell, W. G., & Partsch, C. (2004) · Hormone Research in Paediatrics · doi:10.1159/000079882 · Cited by 48 · see citing works
Hazards of ketoconazole therapy in testotoxicosis
Babovic‐Vuksanovic, D., Donaldson, M., Gibson, N., & Wallace, A. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13192.x · Cited by 46 · see citing works
Comparison of in vitro effects of the pure antiandrogens OH-flutamide, casodex, and nilutamide on androgen-sensitive parameters
Simard, J., Singh, S. M., & Labrie, F. (1997) · Urology · doi:10.1016/s0090-4295(97)00029-0 · Cited by 40 · see citing works
Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome.
Roth, C., Freiberg, C., Zappel, H., & Albers, N. (2002) · PubMed · Cited by 21 · see citing works
Clinical Pharmacokinetics of Aromatase Inhibitors and Inactivators
Lønning, P. E. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342070-00002 · Cited by 20 · see citing works
Familial Male-Limited Precocious Puberty
Leschek, E. (2004) · The Endocrinologist · doi:10.1097/01.ten.0000127927.01216.90 · Cited by 13 · see citing works
Testotoxicosis Proved by Immunohistochemical Analysis and Successfully Treated with Cyproterone Acetate
Itoh, K., Nakada, T., Kubota, Y., Suzuki, H., Ishigooka, M., & Izumi, T. (2010) · Urologia Internationalis · doi:10.1159/000282913 · Cited by 12 · see citing works

Flagged first, then by citations

Sorted by citations

Puberty : ontogeny, neuroendocrinology, physiology, and disorders
Styne, D. M., Grumbach, M. M., Dennis, M., Styne, J., & Melvin, M. N. (1998) · Time to knit · doi:10.1016/b978-1-4160-2911-3.50026-1 · Cited by 546 · see citing works
Precocious Puberty and Normal Variant Puberty: Definition, etiology, diagnosis and current management - Review
Berberoğlu, M. (2009) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.v1i4.3 · Cited by 184 · see citing works
Aromatase inhibitors in men: effects and therapeutic options
de Ronde, W., & de Jong, F. H. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-93 · Cited by 155 · see citing works
Anastrozole Increases Predicted Adult Height of Short Adolescent Males Treated with Growth Hormone: A Randomized, Placebo-Controlled, Multicenter Trial for One to Three Years
Mauras, N., de Pijem, L. G., Hsiang, H. Y., Desrosiers, P., Rapaport, R., Schwartz, I. D., Klein, K. O., Singh, R. J., Miyamoto, A., & Bishop, K. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1559 · Cited by 152 · see citing works
Aromatase inhibitors in pediatrics
Wit, J. M., Hero, M. T., & Nuñez, S. B. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.161 · Cited by 118 · see citing works
Use of Aromatase Inhibitors in Children and Adolescents With Disorders of Growth and Adolescent Development
Shulman, D. I., Francis, G. L., Palmert, M. R., & Eugster, E. A. (2008) · PEDIATRICS · doi:10.1542/peds.2007-2081 · Cited by 90 · see citing works
Normal and Aberrant Growth
Cooke, D. W., DiVall, S. A., & Radovick, S. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00024-9 · Cited by 85 · see citing works
Peripheral Precocious Puberty: Causes and Current Management
Eugster, E. A. (2009) · Hormone Research in Paediatrics · doi:10.1159/000178041 · Cited by 56 · see citing works
Bicalutamide plus Anastrozole for the Treatment of Gonadotropin-Independent Precocious Puberty in Boys with Testotoxicosis: A Phase II, Open-Label Pilot Study (BATT)
Reiter, E. O., Mauras, N., McCormick, K., Kulshreshtha, B., Amrhein, J., De Luca, F., O'Brien, S., Armstrong, J., & Melezinkova, H. (2010) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2010.161 · Cited by 54 · see citing works
Current Concepts in Normal and Abnormal Puberty
Nebesio, T. D., & Eugster, E. A. (2007) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2006.10.005 · Cited by 51 · see citing works
Long‐term treatment of familial male‐limited precocious puberty (testotoxicosis) with cyproterone acetate or ketoconazole
Almeida, M. Q., Brito, V. N., Lins, T. S. S., Guerra‐Júnior, G., de Castro, M., Antonini, S. R. R., Arnhold, I. J. P., Mendonca, B. B., & Latronico, A. C. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03160.x · Cited by 51 · see citing works
The Testes: Disorders of Sexual Differentiation and Puberty in the Male
Hughes, I. A. (2008) · Elsevier eBooks · doi:10.1016/b978-141604090-3.50021-1 · Cited by 50 · see citing works
Bicalutamide and Third-Generation Aromatase Inhibitors in Testotoxicosis
Lenz, A. M., Shulman, D., Eugster, E. A., Rahhal, S., Fuqua, J. S., Pescovitz, O. H., & Lewis, K. A. (2010) · Pediatrics · doi:10.1542/peds.2010-0596 · Cited by 55 · see citing works
Self-citation
Peripheral precocious puberty including congenital adrenal hyperplasia: causes, consequences, management and outcomes
Haddad, N. G., & Eugster, E. A. (2019) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2019.04.007 · Cited by 49 · see citing works
Update on the Role of Aromatase Inhibitors in Growth Disorders
Dunkel, L. (2009) · Hormone Research in Paediatrics · doi:10.1159/000178040 · Cited by 42 · see citing works
Novel approaches to short stature therapy
Wit, J. M., & Oostdijk, W. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.01.003 · Cited by 41 · see citing works
Treatment of precocious puberty in McCune-Albright syndrome.
Mieszczak, J., & Eugster, E. A. (2007) · PubMed · Cited by 37 · see citing works
Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult Height in Familial Male Precocious Puberty
Leschek, E., Flor, A., Bryant, J. C., Jones, J. V., Barnes, K. M., & Cutler, G. B. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.07.047 · Cited by 34 · see citing works
Puberty
Styne, D. M., & Grumbach, M. M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00025-0 · Cited by 34 · see citing works
Novel C617Y mutation in the 7th transmembrane segment of luteinizing hormone/choriogonadotropin receptor in a Japanese boy with peripheral precocious puberty
Nagasaki, K., Katsumata, N., Ogawa, Y., Kikuchi, T., & Uchiyama, M. (2010) · Endocrine Journal · doi:10.1507/endocrj.k10e-227 · Cited by 25 · see citing works
Combined treatment with bicalutamide and anastrozole in a young boy with peripheral precocious puberty due to McCune-Albright Syndrome
Tessaris, D., Matarazzo, P., Mussa, A., Tuli, G., Verna, F., Fiore, L., & Lala, R. (2011) · Endocrine Journal · doi:10.1507/endocrj.ej11-0214 · Cited by 25 · see citing works
Use of aromatase inhibitors in children and adolescents: what's new?
Diaz-Thomas, A., & Shulman, D. I. (2010) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32833ab888 · Cited by 24 · see citing works
Precocious Puberty—Perspectives on Diagnosis and Management
Menon, P. S. N., & Vijayakumar, M. (2013) · The Indian Journal of Pediatrics · doi:10.1007/s12098-013-1177-6 · Cited by 21 · see citing works
Puberty and its disorders in the male
Palmert, M. R., Dunkel, L., & Witchel, S. F. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4858-7.00026-3 · Cited by 15 · see citing works
Adult height in patients with familial male-limited precocious puberty and the role of an aromatase inhibitor in patient management
Lane, L. C., Flowers, J., Johnstone, H., & Cheetham, T. D. (2018) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2017-0363 · Cited by 15 · see citing works
Clinical guidelines «Precocious puberty»
Peterkova, V. A., Алимова, И. Л., Bashnina, E. B., Bezlepkina, O. B., Bolotova, N. V., Zubkova, N. A., Kalinchenko, N. Y., Kareva, M., Kiyaev, A. V., Kolodkina, A. A., et al. (2021) · Problems of Endocrinology · doi:10.14341/probl12821 · Cited by 18 · see citing works
Treatment of Familial Male-limited Precocious Puberty (Testotoxicosis) with Anastrozole and Bicalutamide in a Boy with a Novel Mutation in the Luteinizing Hormone Receptor
Mitre, N., & Lteif, A. (2009) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2009.22.12.1163 · Cited by 12 · see citing works
Third-generation Aromatase Inhibitor Improved Adult Height in a Japanese Boy with Testotoxicosis
Yoshizawa-Ogasawara, A., Katsumata, N., Horikawa, R., Satoh, M., Urakami, T., & Tanaka, T. (2014) · Clinical Pediatric Endocrinology · doi:10.1297/cpe.23.53 · Cited by 11 · see citing works
Pubertad precoz periférica: fundamentos clínicos y diagnóstico-terapéuticos
Guillen, L., & Argente, J. (2011) · Anales de Pediatría · doi:10.1016/j.anpedi.2011.09.014 · Cited by 11 · see citing works
Etiology and therapeutic outcomes of children with gonadotropin-independent precocious puberty
Kang, E., Cho, J. H., Choi, J., & Yoo, H. (2016) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2016.21.3.136 · Cited by 12 · see citing works
A Case of Familial Male-limited Precocious Puberty with a Novel Mutation
Gurnurkar, S., DiLillo, E., & Carakushansky, M. (2020) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.galenos.2020.2020.0067 · Cited by 10 · see citing works
Precocious Puberty in a Boy With Bilateral Leydig Cell Tumors due to a Somatic Gain-of-Function LHCGR Variant
Flippo, C. L., Kolli, V., Andrew, M., Berger, S., Bhatti, T. R., Boyce, A. M., Casella, D. P., Collins, M. T., Délot, E. C., Devaney, J. M., et al. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac127 · Cited by 10 · see citing works
Puberty and Its Disorders in the Male
Palmert, M. R., Chan, Y.-M., & Dunkel, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00018-x · Cited by 10 · see citing works
Bicalutamide-Induced Hepatotoxicity in a Transgender Male-to-Female Adolescent
Wilde, B., Diamond, J. B., Laborda, T. J., Frank, L., O’Gorman, M. A., & Kocolas, I. (2023) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2023.08.024 · Cited by 8 · see citing works
Testotoxicosis without Testicular Mass: Revealed by Peripheral Precocious Puberty and Confirmed by SomaticLHCGRGene Mutation
Daussac, A., Barat, P., Servant, N., Yacoub, M., Missonier, S., Lavran, F., Gaspari, L., Sultan, C., & Paris, F. (2019) · Endocrine Research · doi:10.1080/07435800.2019.1645163 · Cited by 7 · see citing works
Idiopathic gonadotropin-independent precocious puberty – is regular surveillance required?
Arya, V. B., & Davies, J. H. (2019) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2018-0419 · Cited by 7 · see citing works
Presentation and Care for Children with Peripheral Precocious Puberty
Fuqua, J. S., & Eugster, E. A. (2024) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2024.01.006 · Cited by 6 · see citing works
Testotoxicosis with an Episodic Course: An Unusual Case Within a Series
Nabhan, Z. M., & Eugster, E. A. (2018) · AACE Clinical Case Reports · doi:10.4158/accr-2018-0246 · Cited by 6 · see citing works
Long-Term Treatment With Letrozole in a Boy With Familial Male-Limited Precocious Puberty
Yuan, X., Chen, R., Zhang, Y., Yang, X., & Lin, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.906852 · Cited by 5 · see citing works
Central precocious puberty in a case of late-diagnosed familial testotoxicosis and long-term treatment monitoring
Kör, Y. (2018) · HORMONES · doi:10.1007/s42000-018-0029-1 · Cited by 5 · see citing works
Anastrozole for malignant and benign conditions: present applications and future therapeutic integrations
Graham, P. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.14.2347 · Cited by 4 · see citing works
Precocious Puberty
Haddad, N. G., & Eugster, E. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00121-9 · Cited by 2 · see citing works
Aromatase Deficiency and Aromatase Excess
Russell, J. F., Wong, J. C., & Grumbach, M. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416006-4.00012-0 · Cited by 2 · see citing works
Familial male-limited precocious puberty due to an activating mutation of the LHCGR: a case report and literature review
Ha, J., Choi, Y., Jung, M. K., Yoo, E.-G., & Yoo, H. (2024) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2346042.021 · Cited by 1 · see citing works
Precocious Puberty
Fudge, E. B. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8684-8_18 · Cited by 1 · see citing works
Management of Disordered Puberty
Mieszczak, J., Houk, C. P., & Lee, P. A. (2009) · doi:10.1002/9781444316728.ch11 · Cited by 1 · see citing works
„Off-label-Anwendung“ von Aromatasehemmern
Bohlmann, M. K., Hornemann, A., Weichert, J., Stichtenoth, G., Ortmann, J., Diedrich, K., & Lüdders, D. (2008) · Gynäkologische Endokrinologie · doi:10.1007/s10304-008-0265-6 · Cited by 1 · see citing works
Evaluation and management of precocious puberty
Atapattu, N., & Silva, K. D. (2014) · Sri Lanka Journal of Diabetes Endocrinology and Metabolism · doi:10.4038/sjdem.v3i2.6365
Aromatase Inhibitors and Growth Disorders
Dunkel, L., & Hero, M. T. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1795-9_116
Androgens and the Skeleton – Humans
Leder, B. Z. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374602-3.00026-2
Familial Male-Limited Precocious Puberty
Kreher, N. C. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-499-5_18
Self-citation
A severe case of testotoxicosis in an infant due to a c.1732G>C (p.ASP578His) LHCGR gene mutation associated with nodular Leydig cell hyperplasia
AmritBhangoo, A., TaoWang, P., IreneYoung, I., AaronSassoon, A., RobertoTaguibao, R., & AntoineKhoury, A. (2018) · International Journal of Medical Reviews and Case Reports · doi:10.5455/ijmrcr.leydig-cell-hyperplasia-mutation
Precocious Puberty
Fudge, E. B. (2022) · Springer eBooks · doi:10.1007/978-3-030-90684-9_18
Precocious Puberty
Haddad, N. G., & Eugster, E. A. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00121-0
Isosexual Precocious Puberty
Leung, A. K. C. (2009) · Springer eBooks · doi:10.1007/978-3-540-29676-8_1614
American Society of Hypertension, Inc., 23rd Annual Scientific Meeting and Exposition
(2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.93.3.9999
Spectrum of activation and inactivation of gene for the luteinizing hormone chorionic gonadotrophin receptor
Bhangoo, A., & Ten, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821424-4.00030-7
A Rare Cause of Precocious Puberty - Testotoxicosis
Saw, S. H., Idris, A. N., & Lim, P. G. (2024) · Malaysian Journal of Paediatrics and Child Health · doi:10.51407/mjpch.v30i3.313
Peripheral Precocious Puberty: Interventions to Improve Growth
Haddad, N. G., & Eugster, E. A. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1795-9_71

Treatment of Familial Male-limited Precocious Puberty (Testotoxicosis) with Anastrozole and Bicalutamide in a Boy with a Novel Mutation in the Luteinizing Hormone Receptor
Mitre, N., & Lteif, A. (2009) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2009.22.12.1163 · Cited by 12 · see citing works
Combined treatment with bicalutamide and anastrozole in a young boy with peripheral precocious puberty due to McCune-Albright Syndrome
Tessaris, D., Matarazzo, P., Mussa, A., Tuli, G., Verna, F., Fiore, L., & Lala, R. (2011) · Endocrine Journal · doi:10.1507/endocrj.ej11-0214 · Cited by 25 · see citing works
Bicalutamide plus Anastrozole for the Treatment of Gonadotropin-Independent Precocious Puberty in Boys with Testotoxicosis: A Phase II, Open-Label Pilot Study (BATT)
Reiter, E. O., Mauras, N., McCormick, K., Kulshreshtha, B., Amrhein, J., De Luca, F., O'Brien, S., Armstrong, J., & Melezinkova, H. (2010) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2010.161 · Cited by 54 · see citing works
Bicalutamide and Third-Generation Aromatase Inhibitors in Testotoxicosis
Lenz, A. M., Shulman, D., Eugster, E. A., Rahhal, S., Fuqua, J. S., Pescovitz, O. H., & Lewis, K. A. (2010) · Pediatrics · doi:10.1542/peds.2010-0596 · Cited by 55 · see citing works
Self-citation
Central precocious puberty in a case of late-diagnosed familial testotoxicosis and long-term treatment monitoring
Kör, Y. (2018) · HORMONES · doi:10.1007/s42000-018-0029-1 · Cited by 5 · see citing works

Authors: Kreher, N. C., Pescovitz, O. H., Delameter, P., Tiulpakov, A., & Hochberg, Z.
Affiliations: Technion – Israel Institute of Technology (IL)
Corresponding author: Kreher, Nerissa C.
ORCID: Tiulpakov, Anatoly
Hochberg, Ze’ev
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 2006-09
Volume: 149
Issue: 3
Pages: 416-420
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/j.jpeds.2006.04.027
OpenAlex: W2064261438
Cited by: 59
References: 30
Citations by year: 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 3
FWCI: 5.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: familial male-limited precocious puberty, bicalutamide, anastrozole, androgen receptor antagonists, aromatase inhibitors, facial acne, pubic hair, growth rate, skeletal maturation
MeSH terms: Anastrozole, Androgen Antagonists, Anilides, Child, Child, Preschool, Humans, Male, Mutation, Nitriles, Puberty, Precocious, Receptors, LH, Tosyl Compounds, Triazoles, Aromatase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Treatment of familial male-limited precocious puberty with bicalutamide and anastrozole

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks