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Cited by 63Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, Diet

Sex Hormone-Binding Globulin, Oligomenorrhea, Polycystic Ovary Syndrome, and Childhood Insulin at Age 14 Years Predict Metabolic Syndrome and Class III Obesity at Age 24 Years

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Glueck, Charles J., Morrison, John A., Daniels, Stephen, Wang, Ping, Stroop, Davis·2011·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2011.01.018PMC PMC3418049
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Abstract

Objective We hypothesized that oligomenorrhea (menstrual cyclicity ≥42 days), hyperandrogenism, low levels of sex hormone-binding globulin (SHBG), childhood insulin, and metabolic syndrome (MetS) at age 14 years would predict MetS and class III obesity (body mass index ≥40 kg/m(2)) at age 24 years. Study design In this prospective study of schoolgirls, at age 14 years, the girls were categorized as regularly cycling (n = 375), oligomenorrheic (n = 18), or oligomenorrhea plus biochemical hyperandrogenism (polycystic ovary syndrome [PCOS]; n = 12), together designated PCOS. Results Significant explanatory variables for MetS at age 24 years included childhood insulin, MetS, and PCOS category (all positive) and SHBG (negative) at age 14 years. Using categorical data, top decile of childhood insulin, MetS at age 14, bottom decile of SHBG, and PCOS category were significant positive predictors for MetS at age 24. SHBG (negative), black race (positive), and oligomenorrhea (positive) were significant explanatory variables for class III obesity at age 24. Using categorical data, black race, MetS at age 14, bottom decile of SHBG, PCOS category, and top decile of childhood insulin were positive explanatory variables for class III obesity at age 24 years. Conclusions Oligomenorrhea, PCOS (a subcohort of oligomenorrhea), hyperandrogenism, low SHBG, MetS, and childhood insulin at age 14 years may represent a critical, reversible pathway for the development of MetS and class III obesity in young adulthood.

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Authors
Glueck, C. J., Morrison, J. A., Daniels, S., Wang, P., & Stroop, D.
Affiliations
  • Jewish Hospital (US)
  • Cincinnati Children's Hospital Medical Center (US)
Corresponding author
Glueck, Charles J.
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2011-08
Volume
159
Issue
2
Pages
308-313.e2
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2011.01.018
PMC
PMC3418049
OpenAlex
W2011637513
Cited by
63
References
3
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 3 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 10 · 2013: 7 · 2012: 5
FWCI
9.32
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01hc055025-015)
  • U.S. Public Health Service (48941)
  • National Heart, Lung, and Blood Institute (N01-HC055025, U01HL048941, HL52911, HL66430, R01HL066430, R01HL052911, HL55025)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
sex hormone-binding globulin, oligomenorrhea, polycystic ovary syndrome, hyperandrogenism, metabolic syndrome, morbid obesity, adolescent girls, Black race, early adulthood
MeSH terms
Adolescent, Child, Female, Follow-Up Studies, Humans, Hyperaldosteronism, Insulin, Insulin Resistance, Obesity, Morbid, Oligomenorrhea, Polycystic Ovary Syndrome, Prospective Studies, Radioimmunoassay, ROC Curve, Sex Hormone-Binding Globulin, Time Factors, United States, Biomarkers, Body Mass Index, Incidence, Disease Progression, Metabolic Syndrome, Young Adult

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