Use of Blood Polymerase Chain Reaction Testing for Diagnosis of Herpes Simplex Virus Infection
Abstract
The use of herpes simplex virus (HSV) polymerase chain reaction for diagnosis of HSV disease involving the central nervous system has not translated into widespread use for the detection of DNAemia. We report our 6-year experience using blood polymerase chain reaction testing for HSV infection in neonates and older children with HSV disease.
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HSV infections are not ruled out by testing negative in the CSF; additional specimen types such as blood and surface swabs are often necessary for a complete evaluation of HSV, particularly in the newborn.
“Likewise, HSV infections are not ruled out by testing negative in the CSF; additional specimen types such as blood and surface swabs are often necessary for a complete evaluation of HSV, particularly in the newborn (43, 44).”
From Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens (2016) · cites this paper as [43]
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Leber, A. L., Everhart, K., Balada-Llasat, J.-M., Cullison, J., Daly, J., Holt, S., Lephart, P., Salimnia, H., Schreckenberger, P. C., DesJarlais, S., et al. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.00730-16 · Cited by 609 · see citing works
Initial Presentation of Neonatal Herpes Simplex Virus Infection
Curfman, A. L., Glissmeyer, E. W., Ahmad, F. A., Korgenski, E. K., Blaschke, A. J., Byington, C. L., & Miller, A. S. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.02.015 · Cited by 73 · see citing works
- Authors
- Cantey, J. B., Mejías, A., Wallihan, R., Doern, C., Brock, E., Salamon, D., Marcon, M., & Sánchez, P. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Nationwide Children's Hospital (US)
- Children's Medical Center (US)
- Corresponding author
- Sánchez, Pablo J.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 161
- Issue
- 2
- Pages
- 357-361
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2035729251
- Cited by
- 38
- References
- 0
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 2 · 2013: 2
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Keywords
- herpes simplex virus, central nervous system infection, neonatal herpes, viral DNA detection
- MeSH terms
- Adolescent, Child, Child, Preschool, DNA, Viral, Female, Herpes Simplex, Humans, Infant, Infant, Newborn, Male, Polymerase Chain Reaction, Simplexvirus, Central Nervous System Viral Diseases
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