Better nutritional status in early childhood is associated with improved clinical outcomes and survival in patients with cystic fibrosis
Abstract
Objectives To evaluate the relationship between nutritional status early in life and the timing and velocity of height growth, lung function, complications of cystic fibrosis, and survival. Study design Prospective, observational study using data from the Cystic Fibrosis Foundation Registry (US) for patients born between 1989 and 1992 (n = 3142). Results Weight-for-age percentile (WAP) at 4 years of age was positively associated with height-for-age percentiles throughout childhood. Age 4 years WAP >10% was associated with better lung function from 6-18 years of age. In boys and girls with current WAP >50%, peak pubertal height velocities approximated but remained lower than that of the healthy reference population. By age 18 years, patients with an age 4 years WAP >50% suffered fewer acute pulmonary exacerbations, spent fewer days in the hospital, and had lower rates of impaired glucose tolerance or diabetes. Patients attaining higher age 4 years WAP and height-for-age percentiles had a survival advantage throughout childhood. Conclusion For the population studied, greater weight at age 4 years is associated with greater height, better pulmonary function, fewer complications of cystic fibrosis, and better survival through age 18 years. Furthermore, greater weight-for-age in the peripubertal period is associated on average with improved tempo and timing of pubertal height growth.
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BMI in pwCF is closely correlated with improvements in lung function.
“Weight and BMI in pwCF are closely correlated with improvements in lung function and are independent predictors of survival.24,25”
BMI in pwCF is an independent predictor of survival.
“Weight and BMI in pwCF are closely correlated with improvements in lung function and are independent predictors of survival.24,25”
Weight in pwCF is closely correlated with improvements in lung function.
“Weight and BMI in pwCF are closely correlated with improvements in lung function and are independent predictors of survival.24,25”
Weight in pwCF is an independent predictor of survival.
“Weight and BMI in pwCF are closely correlated with improvements in lung function and are independent predictors of survival.24,25”
Cites
Growth and nutritional indexes in early life predict pulmonary function in cystic fibrosis
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European Cystic Fibrosis Society Standards of Care: Framework for the Cystic Fibrosis Centre
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Eating disorders and body image in cystic fibrosis
Darukhanavala, A., Merjaneh, L., Mason, K., & Le, T. (2021) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2021.100280 · Cited by 27 · see citing works
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- Authors
- Yen, E. H., Quinton, H., & Borowitz, D.
- Affiliations
- Boston Children's Hospital (US)
- Dartmouth College (US)
- Women & Children's Hospital of Buffalo (US)
- Corresponding author
- Yen, Elizabeth H.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 162
- Issue
- 3
- Pages
- 530-535.e1
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2114745077
- Cited by
- 306
- References
- 1
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 18 · 2023: 27 · 2022: 21 · 2021: 31 · 2020: 30 · 2019: 32 · 2018: 18 · 2017: 21 · 2016: 32 · 2015: 33 · 2014: 21 · 2013: 8
- FWCI
- 15.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- cystic fibrosis, height-for-age, lung function, pulmonary exacerbations, diabetes mellitus, impaired glucose tolerance, survival
- MeSH terms
- Adolescent, Body Height, Body Weight, Child, Child, Preschool, Cystic Fibrosis, Female, Humans, Lung, Male, Nutritional Status, Prospective Studies, Respiratory Function Tests, Survival Analysis, Glucose Intolerance
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