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Cited by 57Infant Development and Preterm CareNeonatal and fetal brain pathologyNeonatal Respiratory Health Research

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Randomized Trial of Early Developmental Intervention on Outcomes in Children after Birth Asphyxia in Developing Countries

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Carlo, Waldemar A., Goudar, Shivaprasad S., Pasha, Omrana, Chomba, Elwyn, Wallander, Jan L., Biasini, Fred J., McClure, Elizabeth M., Thorsten, Vanessa, Chakraborty, Hrishikesh, Wallace, Dennis, Shearer, Darlene L., Wright, Linda L.·2013·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2012.09.052PMC PMC3582821
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Abstract

Objective To determine if early developmental intervention (EDI) improves developmental abilities in resuscitated children. Study design This was a parallel group, randomized controlled trial of infants unresponsive to stimulation who received bag and mask ventilation as part of their resuscitation at birth and infants who did not require any resuscitation born in rural communities in India, Pakistan, and Zambia. Intervention infants received a parent-implemented EDI delivered with home visits by parent trainers every other week for 3 years starting the first month after birth. Parents in both intervention and control groups received health and safety counseling during home visits on the same schedule. The main outcome measure was the Mental Development Index (MDI) of the Bayley Scales of Infant Development, 2nd edition, assessed at 36 months by evaluators unaware of treatment group and resuscitation history. Results MDI was higher in the EDI (102.6 ± 9.8) compared with the control resuscitated children (98.0 ± 14.6, 1-sided P = .0202), but there was no difference between groups in the nonresuscitated children (100.1 ± 10.7 vs 97.7 ± 10.4, P = .1392). The Psychomotor Development Index was higher in the EDI group for both the resuscitated (P = .0430) and nonresuscitated children (P = .0164). Conclusions This trial of home-based, parent provided EDI in children resuscitated at birth provides evidence of treatment benefits on cognitive and psychomotor outcomes. MDI and Psychomotor Development Index scores of both nonresuscitated and resuscitated infants were within normal range, independent of early intervention.

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  • Few studies have described the neurological outcomes of infants who required resuscitation at birth in low-resource settings, however the scarce evidence available reported similar findings.

    “Few studies have described the neurological outcomes of infants who required resuscitation at birth in low-resource settings, however the scarce evidence available reported similar findings[20–22] and encourages the use of basic resuscitation in such settings.”

    From Early neonatal mortality and neurological outcomes of neonatal resuscitation in a resource-limited setting on the Thailand-Myanmar border: A descriptive study (2018) · cites this paper as [21]

    The Discussion (page unavailable) reports that most resuscitated infants in this multicountry trial had no increased neurodevelopmental impairment at 36 months, supporting the claim that evidence from a low-resource setting found reassuring outcomes. It does not establish that few studies have described these outcomes, and the citing sentence does not specify what earlier findings are considered similar. (LLM, conf=0.82)

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Research works printed but not linked: 28

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Metadata

Authors
Carlo, W. A., Goudar, S. S., Pasha, O., Chomba, E., Wallander, J. L., Biasini, F. J., McClure, E. M., Thorsten, V., Chakraborty, H., Wallace, D., Shearer, D. L., & Wright, L. L.
Affiliations
  • Centre for Infectious Disease Research in Zambia (ZM)
  • Jawaharlal Nehru Medical College (IN)
  • Aga Khan University (PK)
  • University of California, Merced (US)
  • University of Alabama at Birmingham (US)
  • RTI International (US)
  • University of South Carolina (US)
  • Western Kentucky University (US)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
Corresponding author
Carlo, Waldemar A.
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2013-04
Volume
162
Issue
4
Pages
705-712.e3
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2012.09.052
PMC
PMC3582821
OpenAlex
W2079026585
Cited by
57
References
1
Citations by year
2026: 5 · 2025: 1 · 2024: 2 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 2
FWCI
3.37
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Fogarty International Center (R21TW006703, TW006703)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (U01HD040636, U01HD040607, U01HD042372, HD40607, U10HD034216, U01HD043464, U10HD078438, R01HD053055, HD43464, HD42372, HD40636)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Keywords
neonatal asphyxia, neonatal resuscitation, bag-mask ventilation, parent-mediated intervention, home-based intervention, parent training, home visits, cognitive development, psychomotor development, mental development index, Bayley Scales of Infant Development, rural infants, developing countries
MeSH terms
Asphyxia, Child Development, Developmental Disabilities, Cognition Disorders, Developing Countries, Female, Humans, India, Infant, Newborn, Male, Pakistan, Psychomotor Disorders, Surveys and Questionnaires, Resuscitation, Rural Population, Zambia, Treatment Outcome, Early Intervention, Educational

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