A comparison of two probiotic strains of bifidobacteria in premature infants
Open accessAbstract
Objective To determine the impact of 2 probiotic bifidobacteria on the fecal microbiota of premature infants fed either human milk or formula.Study design In the first of two phase 1 clinical trials, 12 premature infants receiving formula feedings were assigned randomly to receive either Bifidobacterium longum ssp infantis or Bifidobacterium animalis ssp lactis in increasing doses during a 5-week period. In the second, 9 premature infants receiving their mother's milk received each of the two bifidobacteria for 2 weeks separated by a 1-week washout period. Serial stool specimens from each infant were analyzed by terminal restriction fragment-length polymorphism and quantitative polymerase chain reaction for bacterial composition.Results Among the formula-fed infants, there was a greater increase in fecal bifidobacteria among infants receiving B infantis (Binf) than those receiving B lactis (Blac). This difference was most marked at a dose of 1.4 × 10(9) colony-forming units twice daily (P < .05). Bacterial diversity improved over dose/time in those infants receiving Binf. Among the human milk-fed infants, greater increases in fecal bifidobacteria and decreases in γ-Proteobacteria followed the administration of Binf than Blac. The B longum group (which includes Binf but not Blac) was the dominant bifidobacteria among the human milk-fed infants, regardless of the probiotic administered.Conclusions Binf was more effective at colonizing the fecal microbiota than Blac in both formula-fed and human milk-fed premature infants. The combination of human milk plus Binf resulted in the greatest fecal levels of bifidobacteria.
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A dose of 4 x 10^9 CFU twice daily was well-tolerated in preterm infants with no vomiting, diarrhea, feeding intolerance, or NEC incidence.
“A dose of 4 x 109 CFU twice daily was well-tolerated in these infants with no vomiting, diarrhea, feeding intolerance, or NEC incidence.”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [54]
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References 40 · Cited by 121
Research works printed but not linked: 1
- [6]Bokulich NA Mills DA Differentiation of mixed lactic acid bacteria communities in beverage fermentations using targeted terminal restriction fragment length polymorphism Food Microbiol 2012 31 126 132 22475950
- Authors
- Underwood, M. A., Kalanetra, K. M., Bokulich, N. A., Lewis, Z. T., Mirmiran, M., Tancredi, D. J., & Mills, D. A.
- Affiliations
- University of California Davis Medical Center (US)
- University of California, Davis (US)
- Corresponding author
- Underwood, Mark A.
- ORCID
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 163
- Issue
- 6
- Pages
- 1585-1591.e9
- ISSN
- 0022-3476 (ISSN-L)
- PMC
- PMC3842430
- OpenAlex
- W2022018183
- Cited by
- 121
- References
- 40
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 11 · 2022: 11 · 2021: 12 · 2020: 12 · 2019: 10 · 2018: 3 · 2017: 15 · 2016: 10 · 2015: 14 · 2014: 8 · 2013: 2
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (UL1 TR000002)
- National Center for Advancing Translational Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-HD059127)
- National Institute of Allergy and Infectious Diseases
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, Bifidobacterium longum subsp. infantis, Bifidobacterium animalis subsp. lactis, preterm infants, fecal microbiota, breast milk, infant formula, probiotic dosage, bacterial diversity, Gammaproteobacteria, probiotic colonization
- MeSH terms
- Bifidobacterium, Breast Feeding, Feces, Female, Humans, Infant, Newborn, Infant, Premature, Male, Probiotics, Infant Formula
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