Health-Related Quality of Life after Open-Heart Surgery
Abstract
Objectives To determine health-related quality of life (HRQoL) in 1-year-old infants with congenital heart disease (CHD), to follow-up with these children at age 4 years, and to examine predictors of HRQoL.Study design Parents of 144 infants who had undergone cardiopulmonary bypass surgery for CHD before age 6 months were prospectively included in this cohort study. Parents completed a standardized questionnaire on child HRQoL at 1 year and 4 years of age; medical data were extracted from the patients' hospital records.Results Parents reported a significant reduction of the children's physical functioning compared with healthy controls at age 1 year. At age 4 years, children with CHD had poorer cognitive functioning but better social functioning compared with healthy controls. Lower HRQoL at age 4 years was not significantly predicted by univentricular or biventricular CHD but was predicted by the presence of an underlying genetic defect, tube feeding at 1 year, and lower HRQoL at 1 year.Conclusion This study shows that HRQoL of infants and preschool-age children with CHD is impaired in physical and cognitive dimensions. Children with lower overall HRQoL at age 1 year, an underlying genetic defect, and tube feeding need to be monitored carefully to provide appropriate and timely interventions.
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Motor and neuropsychological problems can significantly reduce quality of life.
“This is reason for concern, as motor and neuropsychological problems can significantly reduce quality of life.3”
From Perioperative neonatal brain injury is associated with worse school-age neurodevelopment in children with critical congenital heart disease (2018) · cites this paper as [3]
The average IQ score in this cohort of children with CHD was lower than normative means.
“The average IQ score in our cohort of children with CHD was lower than normative means, which is also known from other follow-up studies.3,15”
From Perioperative neonatal brain injury is associated with worse school-age neurodevelopment in children with critical congenital heart disease (2018) · cites this paper as [3]
At school age, motor developmental delays persist in children with all types of congenital heart disease, and IQ is lower than the population average.
“At school age, motor developmental delays persist in children with all types of CHD 11 and IQs are lower than in the average population.[12][13][14]”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [13]
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- Authors
- Werner, H., Latal, B., Valsangiacomo Buechel, E., Beck, I., & Landolt, M. A.
- Affiliations
- University Children's Hospital Zurich (CH)
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 164
- Issue
- 2
- Pages
- 254-258.e1
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2090643403
- Cited by
- 33
- References
- 31
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 8 · 2017: 2 · 2015: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- health-related quality of life, congenital heart disease, infants, open heart surgery, physical function, cognitive function, social functioning, genetic disorders, tube feeding, predictors of quality of life
- MeSH terms
- Child, Preschool, Female, Follow-Up Studies, Heart Defects, Congenital, Cardiac Surgical Procedures, Humans, Infant, Male, Postoperative Period, Prognosis, Prospective Studies, Quality of Life, Surveys and Questionnaires, Social Adjustment
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