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Cited by 117Gestational Diabetes Research and ManagementBirth, Development, and HealthObesity, Physical Activity, Diet

Maternal Obesity, Gestational Weight Gain, and Offspring Adiposity: The Exploring Perinatal Outcomes among Children Study

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Kaar, Jill L., Crume, Tessa, Brinton, John T., Bischoff, Kimberly J., McDuffie, Robert, Dabelea, Dana·2014·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2014.05.050PMC PMC4145019
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Abstract

Objective To determine whether adequate vs excessive gestational weight gain (GWG) attenuated the association between maternal obesity and offspring outcomes. Study design Data from 313 mother-child pairs participating in the Exploring Perinatal Outcomes among Children study were used to test this hypothesis. Maternal prepregnancy body mass index (BMI) and weight measures throughout pregnancy were abstracted from electronic medical records. GWG was categorized according to the 2009 Institute of Medicine criteria as adequate or excessive. Offspring outcomes were obtained at a research visit (average age 10.4 years) and included BMI, waist circumference (WC), subcutaneous adipose tissue (SAT) and visceral adipose tissue, high-density lipoprotein cholesterol, and triglyceride levels. Results More overweight/obese mothers exceeded the Institute of Medicine GWG recommendations (68%) compared with normal-weight women (50%) (P < .01). Maternal prepregnancy BMI was associated with worse childhood outcomes, particularly among offspring of mothers with excessive GWG (increased BMI [20.34 vs 17.80 kg/m(2)], WC [69.23 vs 62.83 cm], SAT [149.30 vs 90.47 cm(2)], visceral adipose tissue [24.11 vs 17.55 cm(2)], and homeostatic model assessment [52.52 vs 36.69], all P < .001). The effect of maternal prepregnancy BMI on several childhood outcomes was attenuated for offspring of mothers with adequate vs excessive GWG (P < .05 for the interaction between maternal BMI and GWG status on childhood BMI, WC, SAT, and high-density lipoprotein cholesterol). Conclusion Our findings lend support for pregnancy interventions aiming at controlling GWG to prevent childhood obesity.

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  • In humans, maternal obesity is associated with an increased risk of their child having increased adiposity during infancy and obesity in adulthood.

    “In humans, maternal obesity is associated with an increased risk of their child having increased adiposity during infancy and obesity in adulthood [85].”

    From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [85]

    The Results report greater adiposity among offspring of overweight or obese mothers, but the children were studied at an average age of 10 years. The Discussion describes associations as early as ages 2–4, not infancy. The introductory passage says obese children tend to become obese adults, but does not establish an association between maternal obesity and offspring obesity in adulthood. Page numbers are unavailable in our copy. (LLM, conf=0.88)

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Authors
Kaar, J. L., Crume, T., Brinton, J. T., Bischoff, K. J., McDuffie, R., & Dabelea, D.
Affiliations
  • University of Colorado Denver (US)
  • Colorado School of Public Health (US)
  • Kaiser Permanente (US)
Corresponding author
Kaar, Jill L.
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2014-09
Volume
165
Issue
3
Pages
509-515
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2014.05.050
PMC
PMC4145019
OpenAlex
W1982977185
Cited by
117
References
1
Citations by year
2026: 2 · 2025: 4 · 2024: 10 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 16 · 2019: 15 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 12
FWCI
10.52
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (UL1TR001082)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK068001)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
maternal obesity, gestational weight gain, offspring adiposity, childhood obesity, pre-pregnancy body mass index, excessive weight gain, waist circumference, subcutaneous adipose tissue, visceral adipose tissue, HDL cholesterol, triglycerides, insulin resistance, Institute of Medicine guidelines, pregnancy interventions
MeSH terms
Adult, Child, Female, Humans, Cholesterol, HDL, Male, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Prospective Studies, Weight Gain, Body Mass Index, Subcutaneous Fat, Waist Circumference

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