Maternal obesity during pregnancy and cardiovascular development and disease in the offspring
Open accessAbstract
Maternal obesity during pregnancy is an important public health problem in Western countries. Currently, obesity prevalence rates in pregnant women are estimated to be as high as 30%. In addition, approximately 40% of women gain an excessive amount of weight during pregnancy in Western countries. An accumulating body of evidence suggests a long-term impact of maternal obesity and excessive weight gain during pregnancy on adiposity, cardiovascular and metabolic related health outcomes in the offspring in fetal life, childhood and adulthood. In this review, we discuss results from recent studies, potential underlying mechanisms and challenges for future epidemiological studies.
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Altered fetal programming in modern societies may be secondary to maternal overnutrition, sedentary behavior, obesity, emotional stress, circadian rhythm disruption, poor gut health or environmental chemical exposure.
“In contrast, altered fetal programming in modern societies may be secondary to maternal overnutrition, sedentary behavior, obesity, emotional stress, circadian rhythm disruption, poor gut health or environmental chemical exposure [35,101,112,113].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [112]
The Hypothesis and Underlying pathways sections (page unavailable) describe fetal programming associated with maternal obesity, excess gestational weight gain, and related nutritional exposures. The cited paper does not support the sentence’s additional proposed contributors: sedentary behavior, emotional stress, circadian disruption, poor gut health, or environmental chemical exposure. (LLM, conf=0.88)
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The Generation R Study: design and cohort update 2017
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Influence of Maternal Obesity on the Long-Term Health of Offspring
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Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
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Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
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“In contrast, altered fetal programming in modern societies may be secondary to maternal overnutrition, sedentary behaviour, obesity, emotional stress, circadian rhythm disruption, poor gut health or environmental chemical exposure (35,101,112,113).”
BackgroundPolycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
parker, J., O'Brien, C., Hawrelak, J., & Gersh, F. (2021) · doi:10.20944/preprints202112.0088.v1 · Cited by 113 · see citing works
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Self-citationRelationship between Obesity and Cognitive Function in Young Women: The Food, Mood and Mind Study
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Stress and Cardiometabolic Disease Risk for Indigenous Populations throughout the Lifespan
Lewis, M. E., Volpert‐Esmond, H. I., Deen, J. F., Modde, E., & Warne, D. K. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041821 · Cited by 65 · see citing works
Maternal Exercise Improves the Metabolic Health of Adult Offspring
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Self-citationMaternal vitamin D deficiency and developmental origins of health and disease (DOHaD)
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Obesity and dyslipidemia in early life: Impact on cardiometabolic risk
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- Authors
- Gaillard, R.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Gaillard, Romy
- ORCID
- Gaillard, Romy
- Venue
- European Journal of Epidemiology
- Published
- 2015-09-16
- Volume
- 30
- Issue
- 11
- Pages
- 1141-1152
- ISSN
- 0393-2990 (ISSN-L)
- 1573-7284
- PMC
- PMC4684830
- OpenAlex
- W1679099184
- Cited by
- 322
- References
- 143
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 24 · 2023: 37 · 2022: 55 · 2021: 32 · 2020: 35 · 2019: 25 · 2018: 29 · 2017: 17 · 2016: 16 · 2015: 2 · 2013: 1
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- European Journal of Epidemiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Funders
- European Commission (2007–2013, FP7 2007-2013, FP7/2007, 289346)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- maternal obesity, pregnancy, excessive weight gain, cardiovascular disease, offspring adiposity, metabolic outcomes, fetal programming, childhood obesity, adult obesity
- MeSH terms
- Cardiovascular Diseases, Female, Humans, Mothers, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Prenatal Exposure Delayed Effects, Risk Factors, Weight Gain, Body Mass Index, Fetal Development
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