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Cited by 27Gastrointestinal motility and disordersPoisoning and overdose treatmentsPharmaceutical studies and practices

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

PEG 3350 Administration Is Not Associated with Sustained Elevation of Glycol Levels

Williams, Kent C., Rogers, Lynette K., Hill, Ivor, Barnard, John, Di Lorenzo, Carlo·2018·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2017.11.028
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Abstract

Objective To determine whether trace amounts of ethylene glycol (EG), diethylene glycol (DEG), or triethylene glycol (TEG) in PEG 3350 are associated with increased blood levels of EG, DEG, or TEG in children receiving daily PEG 3350 therapy.Study design Blood samples were drawn from 9 children who were being treated for constipation with PEG 3350 (6-12 years old) before and every 30 minutes for 3 hours after receiving 17 g of PEG 3350. PEG 3350, tap water, and blood samples from 18 age- and sex-matched controls also were analyzed.Results Baseline blood levels of EG and TEG did not differ between control and treated groups. DEG levels (median [IQR]) were lower in the PEG 3350 group (40.13 ng/mL [36.69, 63.94] vs 92.83 ng/mL [51.06, 128.93], P = .008). After PEG 3350 dose, levels of EG (390.51 ng/mL [326.06, 624.55]) and TEG (2.21 ng/mL [0, 4.5]) peaked at 90 minutes at 1032.81 ng/mL (826.84, 1486.13) (P = .009) and 35.17 ng/mL (15.81, 45.13) (P = .0005), respectively. DEG levels did not significantly change. Standard 17-g doses of PEG 3350 in 8 oz (237 mL) of water resulted in concentrations (mean ± SD) of EG, DEG, and TEG of 1.32 ± 0.23 µg/mL, 0.18 ± 0.03 µg/mL, and 0.12 ± 0.01 µg/mL, respectively. EG, DEG, and TEG levels in public water supply were 0.07 µg/mL, 0.21 µg/mL, and 0.02 µg/mL, respectively.Conclusions Daily PEG 3350 therapy in children was not associated with sustained elevation of EG, DEG, or TEG blood levels over levels in matched controls. Although EG and TEG levels increased after a standard dose of PEG 3350, their peak values remained well below toxic levels.

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Crossref · 10.1016/j.jpeds.2017.11.028

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Research works printed but not linked: 1

  1. Woolf, 1995, Presence of diethylene glycol in commercial polyethylene glycol (PEG) solutions, J Toxicol Clin Toxicol, 33, 490

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Metadata

Authors
Williams, K. C., Rogers, L. K., Hill, I., Barnard, J., & Di Lorenzo, C.
Affiliations
Nationwide Children's Hospital (US)
Corresponding author
Williams, Kent C.
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2018-04
Volume
195
Pages
148-153.e1
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2017.11.028
OpenAlex
W2793999517
Cited by
27
References
31
Citations by year
2026: 4 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 1
FWCI
3.34
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords
polyethylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, constipation, pediatric patients, laxative safety, public water supply, adverse drug reactions, older adults, pregnant women, lactating women
MeSH terms
Child, Constipation, Ethylene Glycols, Female, Humans, Male, Polyethylene Glycols, Biomarkers, Case-Control Studies, Ethylene Glycol, Laxatives

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