CoChat
Sign Up
Cited by 17Growth Hormone and Insulin-like Growth FactorsGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesHypothalamic control of reproductive hormones

Near adult height in girls with Turner syndrome treated with growth hormone following either induced or spontaneous puberty

Lanes, Roberto, Lindberg, Anders, Carlsson, Martin, Chrysis, Dionisios, Aydin, Ferah, Camacho-Hübner, Cecilia, King, Donna, Davenport, Marsha·2019·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2019.04.056
Open this paper in CoChat — free account

Abstract

Objective To understand whether spontaneous vs induced puberty and the type and route of estrogen influence the height of girls with Turner syndrome on growth hormone (GH).Study design Search of an international database of children treated with GH revealed 772 girls with Turner syndrome followed from GH initiation to near adult height. Data from girls with sustained spontaneous puberty (n = 145) were compared with those requiring estrogens for induction or maintenance of puberty (n = 627).Results At GH start, mean age (7.5 vs 7.9 years), weight (-1.7 vs -1.7 SDS), and body mass index (0.2 SDS vs 0.1 SDS) were similar for girls with spontaneous puberty and with induced puberty. Although those girls with spontaneous puberty were shorter than those with induced puberty, when midparental height was taken into consideration, starting heights in both groups averaged -2.8 SDS. Both groups received approximately 0.3 mg/kg/week of GH. Girls with spontaneous puberty initiated puberty and reached near adult height earlier than girls with induced puberty (12.6 ± 1.8 years vs 13.4 ± 1.4 years and 16.0 ± 1.3 years vs 16.9 ± 1.4 years, respectively). Although girls with spontaneous puberty grew more in the first year of GH therapy and between the onset of puberty and near adult height (11.0 cm vs 9.3 cm), height SDS at near adult height and the length of time in puberty before reaching near adult height were comparable. A 45,X karyotype was detected in 22.1% of girls with spontaneous puberty and in 58.4% of girls with induced puberty. Patients receiving transdermal estrogens did not grow better than those on oral estrogens. Adverse event reporting was comparable between groups.Conclusions Girls with Turner syndrome with spontaneous puberty tended to grow better in response to GH than girls with induced puberty, but not enough to produce a difference in height SDS at near adult height.

Integrity signals

Registry

Crossref · 10.1016/j.jpeds.2019.04.056

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • One observational cross-sectional analysis suggested that the impact on adult height of E2 regimens used for pubertal induction was comparable between oral and transdermal routes when using doses that reach the same plasma concentrations of E2.

    “one observational cross-sectional analysis suggested that the impact on adult height of these E2 regimens used for pubertal induction was comparable.”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [295]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Lanes, R., Lindberg, A., Carlsson, M., Chrysis, D., Aydin, F., Camacho-Hübner, C., King, D., & Davenport, M.
Affiliations
  • Hospital Clínico Universitario de Caracas (VE)
  • Pfizer (Sweden) (SE)
  • Pfizer (United States) (US)
  • University of Patras (GR)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Lanes, Roberto
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2019-09
Volume
212
Pages
172-179.e1
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2019.04.056
OpenAlex
W2950047526
Cited by
17
References
27
Citations by year
2024: 6 · 2023: 3 · 2022: 3 · 2021: 5
FWCI
1.62
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Pfizer
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
Turner syndrome, growth hormone therapy, near-adult height, spontaneous puberty, estrogen therapy, transdermal estrogen, oral estrogen, growth response, 45,X karyotype, short stature
MeSH terms
Adolescent, Adult, Body Height, Child, Female, Humans, Puberty, Turner Syndrome, Human Growth Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review