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Cited by 382

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection (MIS-C): A Multi-institutional Study from New York City

Open access
Kaushik, Shubhi, Aydin, Scott I., Derespina, Kim R., Bansal, Prerna B., Kowalsky, Shanna, Trachtman, Rebecca, Gillen, Jennifer K., Perez, Michelle M., Soshnick, Sara H., Conway, Edward E., Bercow, Asher, Seiden, Howard S., Pass, Robert H., Ushay, Henry M., Ofori-Amanfo, George, Medar, Shivanand S.·2020·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2020.06.045
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Abstract

Objective To assess clinical characteristics and outcomes of severe acute respiratory syndrome coronavirus 2-associated multisystem inflammatory syndrome in children (MIS-C). Study design Children with MIS-C admitted to pediatric intensive care units in New York City between April 23 and May 23, 2020, were included. Demographic and clinical data were collected. Results Of 33 children with MIS-C, the median age was 10 years; 61% were male; 45% were Hispanic/Latino; and 39% were black. Comorbidities were present in 45%. Fever (93%) and vomiting (69%) were the most common presenting symptoms. Depressed left ventricular ejection fraction was found in 63% of patients with median ejection fraction of 46.6% (IQR, 39.5-52.8). C-reactive protein, procalcitonin, d-dimer, and pro-B-type natriuretic peptide levels were elevated in all patients. For treatment, intravenous immunoglobulin was used in 18 (54%), corticosteroids in 17 (51%), tocilizumab in 12 (36%), remdesivir in 7 (21%), vasopressors in 17 (51%), mechanical ventilation in 5 (15%), extracorporeal membrane oxygenation in 1 (3%), and intra-aortic balloon pump in 1 (3%). The left ventricular ejection fraction normalized in 95% of those with a depressed ejection fraction. All patients were discharged home with median duration of pediatric intensive care unit stay of 4.7 days (IQR, 4-8 days) and a hospital stay of 7.8 days (IQR, 6.0-10.1 days). One patient (3%) died after withdrawal of care secondary to stroke while on extracorporeal membrane oxygenation. Conclusions Critically ill children with coronavirus disease-2019-associated MIS-C have a spectrum of severity broader than described previously but still require careful supportive intensive care. Rapid, complete clinical and myocardial recovery was almost universal.

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Metadata

Authors
Kaushik, S., Aydin, S. I., Derespina, K. R., Bansal, P. B., Kowalsky, S., Trachtman, R., Gillen, J. K., Perez, M. M., Soshnick, S. H., Conway, E. E., Bercow, A., Seiden, H. S., Pass, R. H., Ushay, H. M., Ofori-Amanfo, G., & Medar, S. S.
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2020-09
Volume
224
Pages
24-29
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2020.06.045
OpenAlex
W3035696387
Cited by
382
References
14
FWCI
69.62
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection (MIS-C): A Multi-institutional Study from New York City. https://app.cochat.ai/papers/10.1016/j.jpeds.2020.06.045
The paper
Kaushik, S., Aydin, S. I., Derespina, K. R., Bansal, P. B., Kowalsky, S., Trachtman, R., Gillen, J. K., Perez, M. M., Soshnick, S. H., Conway, E. E., Bercow, A., Seiden, H. S., Pass, R. H., Ushay, H. M., Ofori-Amanfo, G., & Medar, S. S. (2020). Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection (MIS-C): A Multi-institutional Study from New York City. The Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2020.06.045

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.