Disulfiram activation of prostaglandin E2 synthesis: a novel antifibrotic mechanism in pulmonary fibrosis

A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.

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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

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Developmental pathways in the pathogenesis of lung fibrosis

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Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

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Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

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Matrix abnormalities in pulmonary fibrosis

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Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology

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Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases

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Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes

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TGF-β Effects on Prostate Cancer Cell Migration and Invasion Are Mediated by PGE2 through Activation of PI3K/AKT/mTOR Pathway

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Re-evaluation of Fibrogenic Cytokines in Lung Fibrosis

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Reversal of Myofibroblast Differentiation by Prostaglandin E2

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IPF: new insight on pathogenesis and treatment

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The roles of the COX2/PGE2/EP axis in therapeutic resistance

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Disulfiram combined with copper inhibits metastasis and epithelial–mesenchymal transition in hepatocellular carcinoma through the NF ‐κB and TGF ‐β pathways

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A myeloma paraprotein with specificity for platelet glycoprotein IIIa in a patient with a fatal bleeding disorder.

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Current Findings and Mechanisms of Action of Disulfiram in the Treatment of Alcohol Dependence

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Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity

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TGF-β1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells

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Disulfiram Treatment Normalizes Body Weight in Obese Mice

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Crystalline silica-induced macrophage pyroptosis interacting with mitophagy contributes to pulmonary fibrosis via modulating mitochondria homeostasis

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Reversal of the Transcriptome by Prostaglandin E2 during Myofibroblast Dedifferentiation

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Nintedanib in Progressive Pulmonary Fibrosis: A Systematic Review and Meta-Analysis

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Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis

Zhang, Y. L., Zhang, R., & Han, X. (2021) · Inflammation Research · doi:10.1007/s00011-021-01457-y · Cited by 61 · see citing works

PGE2 receptor EP2 mediates the antagonistic effect of COX‐2 on TGF‐β signaling during mammary tumorigenesis

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Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring

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Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis

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Prostaglandin E2 inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca2+ signaling

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Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway

Pei, X., Zheng, F., Li, Y., Lin, Z., Han, X., Feng, Y., Tian, Z., Ren, D., Cao, K., & Li, C. (2022) · Cells · doi:10.3390/cells11030346 · Cited by 50 · see citing works

Disulfiram-based disulfides as narrow-spectrum antibacterial agents

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Antibacterial activity of disulfiram and its metabolites

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Lung Myofibroblasts Are Characterized by Down-Regulated Cyclooxygenase-2 and Its Main Metabolite, Prostaglandin E2

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Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism

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CXCR4-Overexpressing Umbilical Cord Mesenchymal Stem Cells Enhance Protection against Radiation-Induced Lung Injury

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EGFR Signaling Is Required for TGF-β1–Mediated COX-2 Induction in Human Bronchial Epithelial Cells

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Apigenin inhibits TGF-β1 induced fibroblast-to-myofibroblast transition in human lung fibroblast populations

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Calreticulin regulates TGF-β1-induced epithelial mesenchymal transition through modulating Smad signaling and calcium signaling

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Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis

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Diethyldithiocarbamate, an anti‐abuse drug, alleviates steatohepatitis and fibrosis in rodents through modulating lipid metabolism and oxidative stress

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Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation

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Effects of Instillation of Eyedrops Containing Disulfiram and Hydroxypropyl-β-Cyclodextrin Inclusion Complex on Endotoxin-Induced Uveitis in Rats

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MAP3K8 Regulates Cox-2–Mediated Prostaglandin E2 Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis

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Disulfiram inhibits epithelial–mesenchymal transition through TGFβ–ERK–Snail pathway independently of Smad4 to decrease oral squamous cell carcinoma metastasis

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Inhibitory Effects of Oral Disulfiram on Endotoxin-Induced Uveitis in Rats

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Antifibrotic drugs in connective tissue disease-related interstitial lung disease (CTD-ILD): from mechanistic insights to therapeutic applications

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Disulfiram protects against abdominal aortic aneurysm by ameliorating vascular smooth muscle cells pyroptosis

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Disulfiram Exerts Antifibrotic and Anti-Inflammatory Therapeutic Effects on Perimysial Orbital Fibroblasts in Graves’ Orbitopathy

Wang, X., Ye, H., Yang, S., Sha, X., Wang, X., Zhang, T., Chen, R., Xiao, W., & Yang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095261 · Cited by 12 · see citing works

Disulfiram Alleviates MTX-Induced Pulmonary Fibrosis by Inhibiting EMT in Type 2 Alveolar Epithelial Cells

Wu, X., Xu, H., Zhang, Z., Ma, Z., Zhang, L., Wang, C., Lan, K., Li, R., & Chen, M. (2024) · Lung · doi:10.1007/s00408-024-00764-5 · Cited by 6 · see citing works

Off-label and repurposed use of disulfiram beyond alcohol dependence: A systematic review of clinical and preclinical evidence

Benkő, B.-M., De Brito Parreirinha, N. S., Sebe, I., & Zelkó, R. (2026) · iScience · doi:10.1016/j.isci.2026.115441 · Cited by 2 · see citing works

Inhalable disulfiram pure-drug nanoparticles stabilized by phospholipid/TPSS for effective pulmonary fibrosis treatment in mice

Liu, X., & Chai, G. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.126833 · Cited by 1 · see citing works

Disulfiram Exerts anti-pulmonary Fibrosis Effect by Activating PGE2 SynthesisPreprint

Pei, X., Zheng, F., Li, Y., Lin, Z., Zhang, Y., Han, X., Feng, Y., Li, F., Yang, J., Li, T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.16.537099

Disulfiram Regulates Epithelial-Mesenchymal Transition by Activating PGE 2 Biosynthesis to Improve Idiopathic Pulmonary Fibrosis

Li, C., Pei, X., Zheng, F., Cao, K., & Ren, D. (2021) · doi:10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4439 · Cited by 1 · see citing works

Disruption of prostaglandin F2α receptor signaling attenuates fibrotic remodeling in a preclinical murine model of idiopathic pulmonary fibrosis

Beers, M. F., Tang, S. Y., Rodriguez, L., Tomer, Y., Murthy, A., Cai, T.-Q., Connelly, C. F., Gillich, A., Wong, Y. L., & FitzGerald, G. (2022) · doi:10.1183/13993003.congress-2022.548

Exploring Combined Therapy: Disulfiram and Antifibrotic Agents in Attenuating Pulmonary Fibrosis in Bleomycin-Induced Mouse Model

Sato, M., Urushiyama, H., Toda, E., Takumida, H., Enokido, T., Saito, A., Terashima, Y., & Kage, H. (2024) · doi:10.1183/13993003.congress-2024.pa3372 · Cited by 1 · see citing works

Diallyl disulfide inhibits proliferation and transdifferentiation of lung fibroblasts through induction of cyclooxygenase and synthesis of prostaglandin E2

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