The cancer cell secretome: A good source for discovering biomarkers?
Abstract
Cancer is a leading cause of death. Early detection is usually associated with better clinical outcomes. Recent advances in genomics and proteomics raised hopes that new biomarkers for diagnosis, prognosis or monitoring therapeutic response will soon be discovered. Proteins secreted by cancer cells, referred also as "the cancer cell secretome", is a promising source for biomarker discovery. In this review we will summarize recent advances in cancer cell secretome analysis, focusing on the five most fatal cancers (lung, breast, prostate, colorectal, and pancreatic). For each cancer type we will describe the proteomic approaches utilized for the identification of novel biomarkers. Despite progress, identification of markers that are superior to those currently used has proven to be a difficult task and very few, if any, newly discovered biomarker has entered the clinic the last 10 years.
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About 10% of human genome open reading frames encode secreted proteins.
“Importantly, approximately 10% of the human genome open reading frames encode proteins that are secreted (117).”
From The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology (2014) · cites this paper as [117]
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Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709 · see citing works
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Jayatilaka, H., Tyle, P., Chen, J. J., Kwak, M., Ju, J., Kim, H. J., Lee, J. S. H., Wu, P.-H., Gilkes, D. M., Fan, R., et al. (2017) · Nature Communications · doi:10.1038/ncomms15584 · Cited by 177 · see citing works
The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology
Greco, T. M., Diner, B. A., & Cristea, I. M. (2014) · Annual Review of Virology · doi:10.1146/annurev-virology-031413-085527 · Cited by 67 · see citing works
Global Secretome Characterization of Herpes Simplex Virus 1-Infected Human Primary Macrophages
Miettinen, J. J., Matikainen, S., & Nyman, T. A. (2012) · Journal of Virology · doi:10.1128/jvi.01545-12 · Cited by 48 · see citing works
- Authors
- Pavlou, M. P., & Diamandis, E. P.
- Affiliations
- Mount Sinai Hospital (CA)
- Corresponding author
- Diamandis, Eleftherios P.
- Venue
- Journal of Proteomics
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 73
- Issue
- 10
- Pages
- 1896-1906
- ISSN
- 1874-3919 (ISSN-L)
- OpenAlex
- W2005497218
- Cited by
- 200
- References
- 1
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 15 · 2019: 11 · 2018: 10 · 2017: 13 · 2016: 19 · 2015: 17 · 2014: 24 · 2013: 18 · 2012: 16
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Proteomics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- biomarker discovery, secreted proteins, cancer proteomics, early cancer detection, lung cancer, breast cancer, prostate cancer, colorectal cancer, pancreatic cancer, treatment response monitoring
- MeSH terms
- Breast Neoplasms, Female, Humans, Lung Neoplasms, Male, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Biomarkers, Tumor, Colorectal Neoplasms, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Early Diagnosis, Cell Line, Tumor
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