The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: A potential link between epigenetics and schizophrenia
Abstract
Genetic and epigenetic factors can potentially alter susceptibility to psychiatric disorders such as schizophrenia. In order to explore the effect of epigenetics on the pathogenesis of schizophrenia, we examined the global methylation level of leukocyte DNA from 210 patients with schizophrenia (124 males and 86 females) and 237 healthy subjects (108 males and 129 females). Methylated deoxycytidine (mC) content in peripheral leukocyte DNA was measured by high performance liquid chromatography (HPLC). We confirmed in the healthy subjects our previous finding that there are sex-dependent differences in mC content (males>females; beta=0.319, p<0.001), in addition to the effect of age (beta=-0.141, p=0.022). We therefore used multiple regression to analyze the data from all subjects by sex, with age as a co-variant. In males, a tendency was observed toward lower mC content in patients than in controls (beta=-0.115, p=0.075), with a significant effect of age (beta=-0.212, p<0.001). This difference was more prominent in younger individuals. In females, no effect of age or disease status on mC content was observed. These results established that there is significant sex-dependent difference in the mC content of human peripheral leukocyte DNA, and raise the possibility that alterations in DNA methylation state are present in patients with schizophrenia.
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“In both human and animal models, it has been observed treatment with haloperidol induces sex-specific DNA methylation differences [71, 72].”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [72]
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Cites
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Review Article Epigenetic Studies in Human Diseases
Šafárik, P. J. (2010)
Ethnopharmacological and genetic study on the treatment of mental disorders: a systematic review
Lima, C. K. T., Pontes, L. Q., Pinho, L. G., Bezerra, M. R. L., Barroso, W. D. S., Júnior, A. G. T., Alves, M. N. T., Macedo, J. C. B., Feitosa, U. N. S., Neto, J. L. D. A., et al. (2015) · International Archives of Medicine · doi:10.3823/1787
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Dmitrzak‐Węglarz, M., & Hauser, J. (2009) · Via Medica Journals · Cited by 3
Global DNA methylation and depression: Preliminary result from community based epidemiological study
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Mecanismos envolvidos no perfil antipsicótico do canabidiol
Pedrazzi, J. F. C. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2019.tde-30042019-163956
Effects of MAOA promoter methylation on susceptibility to paranoid schizophrenia
ChenJiexu, Y., Zhang, Z., & Xu, Y. (2012)
Cottrell, S. E., deVos, T., Distler, J., Haefliger, C., Lesche, R., Plum, A., & Schuster, M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374934-5.00006-4
Additional file 2 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490464
Additional file 1 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490461
Metadata
- Authors
- Shimabukuro, M., Sasaki, T., Imamura, A., Tsujita, T., Fuke, C., Umekage, T., Tochigi, M., Hiramatsu, K., Miyazaki, T., Oda, T., Sugimoto, J., Jinno, Y., & Okazaki, Y.
- Affiliations
- University of the Ryukyus (JP)
- The University of Tokyo (JP)
- Nagasaki University (JP)
- Mie University (JP)
- Corresponding author
- Jinno, Yoshihiro
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 41
- Issue
- 12
- Pages
- 1042-1046
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2148944032
- Cited by
- 108
- References
- 40
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 14
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- schizophrenia, DNA methylation, global hypomethylation, peripheral blood leukocytes, epigenetics, sex differences, age effects
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Chromatography, High Pressure Liquid, Female, Humans, Leukocytes, Male, Middle Aged, Schizophrenia, Sex Factors, DNA Methylation, Epigenesis, Genetic
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