Vasopressin–neurophysin and DST in major depression: Relationship with suicidal behavior
Abstract
The purpose of the present study was to assess if AVP-neurophysin is associated with hypercortisolemia and suicidal behaviour in depressed patients. The study included 28 patients subgrouped into suicide attempters (n=13) and nonattempters (n=15). We assessed basal AVP-neurophysins concentrations and post-dexamethasone (DST) cortisol levels. Concentrations of AVP-neurophysins did not differ between DST suppressors and nonsuppressors: 0.29+/-0.13 ng/ml vs 0.36+/-0.21 ng/ml, (F=1.1, df=1, 27, p=0.30). Suicide attempters did not differ from nonattempters for AVP-neurophysins levels. Our results fail to support a role of AVP in the early cortisol escape.
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Nonsuppression on the dexamethasone suppression test predicts suicide, but there is disagreement about nonfatal attempts.
“Nonsuppression on the dexamethasone suppression test, which assesses this HPA axis glucocorticoid receptor feedback loop, predicts suicide (151-153), but there is disagreement about nonfatal attempts (154-158).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [157]
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References 38 · Cited by 26
- Authors
- Pitchot, W., Scantamburlo, G., Pinto, E., Hansenne, M., Reggers, J., Ansseau, M., & Legros, J.-J.
- Affiliations
- University of Liège (BE)
- Corresponding author
- Scantamburlo, Gabrielle
- ORCID
- Hansenne, Michel
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 42
- Issue
- 8
- Pages
- 684-688
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W1999405225
- Cited by
- 26
- References
- 38
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- vasopressin, neurophysin, major depressive disorder, suicidal behavior, suicide attempters, dexamethasone suppression test, cortisol, hypercortisolism, hypothalamic-pituitary-adrenal axis
- MeSH terms
- Adult, Circadian Rhythm, Depressive Disorder, Major, Major Depressive Disorder, Dexamethasone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Neurophysins, Pituitary-Adrenal System, Suicide, Attempted
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