Effects of different stimulation parameters on the antidepressant-like response of medial prefrontal cortex deep brain stimulation in rats

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585

Depression: a new animal model sensitive to antidepressant treatments

PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451

Deep Brain Stimulation for Treatment-Resistant Depression

Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059

Behavioural despair in rats: A new model sensitive to antidepressant treatments

Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138

Neurons in medial prefrontal cortex signal memory for fear extinction

Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836

Assessing antidepressant activity in rodents: recent developments and future needs

Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551

Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants

Detke, M. J., Rickels, M. R., & Lucki, I. (1995) · Psychopharmacology · doi:10.1007/bf02245592 · Cited by 1,466

The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress

Diorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151

Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

Cryan, J. F., Valentino, R. J., & Lucki, I. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.008 · Cited by 1,138

Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression

Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301408 · Cited by 1,027

Measuring paw preferences in dogs, cats and rats: Design requirements and innovations in methodology

Isparta, S., Yargın, G. T., Wagner, S. C., Mundorf, A., Kul, B. Ç., Pereira, G. G., Güntürkün, O., Ocklenburg, S., Freund, N., & Demirbaş, Y. S. (2024) · Laterality Asymmetries of Body Brain and Cognition · doi:10.1080/1357650x.2024.2341459 · Cited by 9

A narrative review on invasive brain stimulation for treatment-resistant depression

Dandekar, M. P., Díaz, A. P., Rahman, Z., da Silva, R. H., Nahas, Z. H., Aaronson, S. T., Selvaraj, S., Fenoy, A. J., Sanches, M., Soares, J. C., et al. (2021) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2021-1874 · Cited by 12

Tiefe Hirnstimulation bei neurologischen und psychiatrischen Erkrankungen

Winter, C., Harnack, D., & Kupsch, A. R. (2010) · Der Nervenarzt · doi:10.1007/s00115-010-2936-5 · Cited by 8

Subanesthetic ketamine exerts antidepressant-like effects in adult rats exposed to juvenile stress

Aikawa, K., Yoshida, T., Ohmura, Y., Lyttle, K. A., Yoshioka, M., & Morimoto, Y. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146980 · Cited by 8

An Investigation Into Miniaturised Closed-Loop DBS Devices

Corva, D. M., Adams, S. D., Bennet, K. E., Hashemi, P., Berk, M., & Kouzani, A. Z. (2021) · IEEE Transactions on Medical Robotics and Bionics · doi:10.1109/tmrb.2021.3095361 · Cited by 8

Automated Neuroanatomical Relation Extraction: A Linguistically Motivated Approach with a PVT Connectivity Graph Case Study

Gökdeniz, E., Özgür, A., & Canbeyli, R. S. (2016) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2016.00039 · Cited by 8

Right-but not left-paw use in female rats provides advantage in forced swim tests

Soyman, E., Tunçkol, E., Lacin, E., & Canbeyli, R. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.027 · Cited by 8

Deep brain stimulation of the lateral hypothalamus to block morphine reward: Does the intensity of stimulation matter?

Nikbakhtzadeh, M., Ashabi, G., Keshavarz, M., & Riahi, E. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114159 · Cited by 6

SmartStim: An Artificial Intelligence Enabled Deep Brain Stimulation Device

Corva, D. M., Parke, B., West, A. M., Doeven, E. H., Adams, S. D., Tye, S. J., Hashemi, P., Berk, M., & Kouzani, A. Z. (2024) · IEEE Transactions on Medical Robotics and Bionics · doi:10.1109/tmrb.2024.3381341 · Cited by 6

Deep brain stimulation mitigates memory deficits in a rodent model of traumatic brain injury

Rabelo, T. K., Campos, A. C. P., Almeida-Souza, T. H., Mahmud, F., Popović, M. R., Covolan, L., Betta, V. H. C., DaCosta, L., Lipsman, N., Diwan, M., et al. (2024) · Brain stimulation · doi:10.1016/j.brs.2024.10.006 · Cited by 6

Associations between resting state brain activity and A1 adenosine receptor availability in the healthy brain: Effects of acute sleep deprivation

Li, C., Kroll, T., Matusch, A., Aeschbach, D., Bauer, A., Elmenhorst, E., & Elmenhorst, D. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1077597 · Cited by 6

Increased antidepressant sensitivity after prefrontal cortex glucocorticoid receptor gene deletion in mice

Hussain, R. J., & Jacobson, L. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.019 · Cited by 6

Antidepressant-like effects of cinnamamide derivative M2 via D2 receptors in the mouse medial prefrontal cortex

Che, Y.-X., Jin, X., Xiao, R.-H., Ming, Z., Ma, X., Guo, F., & Li, Y. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00854-7 · Cited by 6

Sex differences in long-term fear and anxiety-like responses to deep brain stimulation in a preclinical model of PTSD

Almeida-Souza, T. H., Campos, A. C. P., Rabelo, T. K., Emtyazi, D., McCann, E., Brandão‐Lima, P. N., Diwan, M., Lipsman, N., & Hamani, C. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.02.041 · Cited by 4

Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain

Browne, C. A., Clarke, G. A., Hanke, J., Dinan, T. G., Schwegler, H., Yilmazer‐Hanke, D., & Cryan, J. F. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.012 · Cited by 4

Supraorbital Stimulation Does Not Induce an Antidepressant-like Response in Rats

Bregman, T., Diwan, M., Nóbrega, J. N., & Hamani, C. (2013) · Brain stimulation · doi:10.1016/j.brs.2013.11.002 · Cited by 4

Reply to: Electrical Brain Stimulation in Depression: Which Target(s)?

Hamani, C., Diwan, M., Raymond, R., Nóbrega, J. N., de Macedo, C. E. A., Brandão, M. L., Shumake, J., Gonzalez-Lima, F., Lozano, A. M., & Fletcher, P. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.012 · Cited by 4

What do we know about astrocytes and the antidepressant effects of DBS?

Campos, A. C. P., Pagano, R. L., Lipsman, N., & Hamani, C. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114501 · Cited by 4

Chronic, multi-contact, neural interface for deep brain stimulation

Tooker, A., Madsen, T. E., Crowell, A. L., Shah, K. G., Felix, S. H., Mayberg, H. S., Pannu, S. S., Rainnie, D. G., & Tolosa, V. M. (2013) · International IEEE/EMBS Conference on Neural Engineering · doi:10.1109/ner.2013.6696154 · Cited by 3

Deep Brain Stimulation in Animal Models of Depression

Scott, B. W., Nóbrega, J. N., & Hamani, C. (2012) · Springer eBooks · doi:10.1007/978-3-642-30991-5_11 · Cited by 3

Selective stimulation of the subthalamic nucleus in Parkinson’s disease: dream or near future

Janssen, M. L. F. (2015) · Research Publications (Maastricht University) · doi:10.26481/dis.20150513mj · Cited by 2

Deep brain stimulation

Krauss, J. K., & Nagel, J. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00212-6 · Cited by 2

Design Considerations for Implantable Neural Circuits and Systems

Hsu, W.-Y., Hsieh, P.-H., & Chen, H. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_19 · Cited by 1

Toward Non-Invasive Electrical Stimulation for Guided Optic Nerve Regeneration

Pahlavan, P., Mayer, P. S., Simonyan, A., Cavaleri, J., Huang, C. Y., Briggs, R. G., Zada, G., Lee, D. J., Gokoffski, K. K., & Lazzi, G. (2025) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2025.3603560 · Cited by 1

Rapid rescue of despair behaviors by sonogenetic neuromodulation of the mPFC-DRN pathway

Lei, T., Xian, Q., Li, D., Su, M., Wu, Y., Hou, X., Jing, J., Jiang, Y., Huang, X., Wong, K. F., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03616-1 · Cited by 1

Deep Brain Stimulation for Depression: An Update

Ryder, J. G., & Holtzheimer, P. E. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0073-6 · Cited by 2

Effects of lateral habenula and ventral medial prefrontal cortex deep brain stimulation in rats

Fan, T., Zhang, Y., Wang, Z., Yi, M., Liu, N., Hu, C., & Luo, L. (2022) · Journal of Neurorestoratology · doi:10.26599/jnr.2022.9040006 · Cited by 1

Robust Evaluation of Paw Preference Using Three Validated Tests in Sprague Dawley RatsPreprint

Pokharel, D., Le, K.-P. N., Beligala, D. H., Subramanian, T., & Venkiteswaran, K. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5366464 · Cited by 1

SEROTONIN IN EMOTIONAL MEMORY PROCESSES: NEUROPHARMACOLOGICAL STUDIES WITH EMPHASIS ON DEPRESSION

Eriksson, T. (2012) · Figshare

Participação do sistema glutamatérgico do córtex pré-frontal medial ventral na modulação das consequências comportamentais do estresse de nado forçado

Pereira, V. S. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2011.tde-11082011-132630

Novel insights towards memory restoration

Hescham, S.-A. (2015) · Research Publications (Maastricht University) · doi:10.26481/dis.20151215sh

Ablative Neurotherapeutics and Deep Brain Stimulation in Animal Models of Psychiatric Disorders

Baunez, C. (2016) · Springer eBooks · doi:10.1007/978-1-59745-495-7_9

Potential Utility of Optogenetics in the Study of

Lobo, D. K., Nestler, E. J., & Covington, H. E. (2012)

Real-Time Programmable Closed-Loop Stimulation/Recording Platforms for Deep Brain Study

Chiu, H.-C., & Ma, H. (2016) · Springer eBooks · doi:10.1007/978-3-319-33201-7_10

Neuromodulation for depression: Insights gained from neuroimaging and computational models

Pathak, Y. J. (2014) · e-Publications@Marquette (Marquette University)

Deep Brain Stimulation: A Promising Therapeutic Approach to the Treatment of Severe Depressed Patients — Current Evidence and Intrinsic Mechanisms

Pérez-Caballero, L., Torres-Sánchez, S., Micó, J. A., & Berrocoso, E. (2017) · Springer eBooks · doi:10.1007/978-3-319-53126-7_19

Probing Neural Communication by Expanding In Vivo Electrochemical and Electrophysiological Measurements

Parent, K. L. (2017) · UA Campus Repository (The University of Arizona)

Investigating the Behavioural and Antiapoptotic Effects of Deep Brain Stimulation in a Model of Moderate-to-severe Traumatic Brain Injury

Mahmud, F. A. (2021) · TSpace (University of Toronto)

Design Considerations for Implantable Neural Circuits and Systems

Hsu, W.-Y., Hsieh, P.-H., & Chen, H. (2021) · Handbook of Neuroengineering · doi:10.1007/978-981-15-2848-4_19-1

Faculty Opinions recommendation of Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex.

Hen, R. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.7494957.7789055

Changes in myelinated nerve fibers induced by pulsed electrical stimulation: A microstructural perspective on the causes of electrical stimulation side effects

Zhao, H., Li, Y., Zhang, Y., & Zhang, C. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149331

119. Dopamine and Serotonin Transients Predict Depressive Symptom Relief Following Deep Brain Stimulation of Human Subcallosal Cingulate Cortex

Shevlin, B. R. K., Fu, Q. X., Batten, S. R., Kopell, B. H., Davis, A. N., Heflin, M., Heisig, S., Rozell, C. J., Kato, A., Kulkarni, K. R., et al. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.03.353

The Amelioration of Depression-Like Behaviors in Mice by Deep Brain Stimulation of the Ventromedial Prefrontal Cortex Is Associated With Neuroinflammation

Tao, W., Qiaolin, Z., Ning, X., & Caiy, Z. (2026) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2026.04.021

Rigorous validation of paw preference using three complementary behavioral assays in Sprague Dawley rats

Pokharel, D., Le, K., Beligala, D. H., Subramanian, T., & Venkiteswaran, K. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116366

Acute unilateral DBS of the basolateral amygdala does not affect motricity, anxiety-like behavior, or fear memory consolidation in rats

Formolo, D. A., Drabowski, N. R., Mello, H. M., Hoeller, A. A., de Carvalho, C. R., Neto, A. T., & Walz, R. (2026) · Experimental Brain Research · doi:10.1007/s00221-026-07408-5

Antidepressant-Like Effects of Medial Prefrontal Cortex Deep Brain Stimulation in Rats

Hamani, C., Diwan, M., Macedo, C. E., Brandão, M. L., Shumake, J., Gonzalez-Lima, F., Raymond, R., Lozano, A. M., Fletcher, P. J., & Nobrega, J. N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.025 · Cited by 324

Effects of lateral habenula and ventral medial prefrontal cortex deep brain stimulation in rats

Fan, T., Zhang, Y., Wang, Z., Yi, M., Liu, N., Hu, C., & Luo, L. (2022) · Journal of Neurorestoratology · doi:10.26599/jnr.2022.9040006 · Cited by 1

Testing different paradigms to optimize antidepressant deep brain stimulation in different rat models of depression

Rummel, J., Voget, M., Hadar, R., Ewing, S. G., Sohr, R., Klein, J., Sartorius, A., Heinz, A., Mathé, A. A., Vollmayr, B., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.06.016 · Cited by 38

Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms

Lim, L. W., Prickaerts, J., Huguet, G., Kadar, E., Hartung, H., Sharp, T., & Temel, Y. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.24 · Cited by 116

Effects of different patterns of electric stimulation of the ventromedial prefrontal cortex on hippocampal–prefrontal coherence in a rat model of depression

Jia, L., Sun, Z., Shi, D., Wang, M., Jia, J., He, Y., Xue, F., Ren, Y., Yang, J., & Ma, X. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.08.032 · Cited by 27