Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration

Tissue sulfhydryl groups

Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,824

Guide for the Care and Use of Laboratory Animals: Eighth Edition

(2011) · doi:10.17226/12910 · Cited by 16,199

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study

Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007

A Meta-Analysis of Cytokines in Major Depression

Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,241

Tests for emotionality in rats and mice: A review

Archer, J. (1973) · Animal Behaviour · doi:10.1016/s0003-3472(73)80065-x · Cited by 1,577

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232

Antidepressant-like effects of solidagenone on mice with bacterial lipopolysaccharide (LPS)-induced depression

Locateli, G., Alves, B. D. O., Miorando, D., Ernetti, J., Alievi, K., Zilli, G. A. L., Serpa, P. Z., Vecchia, C. A. D., da Silva, L. M., Müller, L. G., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112863 · Cited by 20

Diene Valepotriates fromValeriana glechomifoliaPrevent Lipopolysaccharide-Induced Sickness and Depressive-Like Behavior in Mice

Müller, L. G., Borsoï, M., Stolz, E. D., Herzfeldt, V., Viana, A. F., Ravazzolo, A. P., & Rates, S. M. K. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/145914 · Cited by 20

Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress

Wei, X., Ma, Y., Li, F., He, H., Huang, H., Huang, C., Chen, Z., Chen, D., Chen, J., & Yuan, X. (2021) · Inflammation · doi:10.1007/s10753-021-01423-0 · Cited by 19

Inhibition of vascular adhesion protein 1 protects dopamine neurons from the effects of acute inflammation and restores habit learning in the striatum

Becchi, S., Buson, A., & Balleine, B. W. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02288-8 · Cited by 17

Niacin modulates depressive-like behavior in experimental colitis through GPR109A-dependent mechanisms

Wadie, W., Mohamed, S. S., El-Haleim, E. A. A., & Khayyal, M. T. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122004 · Cited by 18

Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations

Filho, P. W. L. L., Filho, A. J. M. C., Vieira, C. F. X., Oliveira, T. D. Q., Soares, M. V. R., Jucá, P. M., Quevedo, J., Barichello, T., Macêdo, D. S., & Medeiros, F. D. C. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00397-1 · Cited by 18

Central immune alterations in passive strategy following chronic defeat stress

Pérez-Tejada, J., Arregi, A., Azpiroz, A., Beitia, G., Gómez-Lázaro, E., & Garmendia, L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.11.015 · Cited by 20

Lectin isolated from the red marine alga Solieria filiformis (Kützing) P.W. Gabrielson: Secondary structure and antidepressant-like effect in mice submitted to the lipopolysaccharide-induced inflammatory model of depression

Abreu, T. M., Corpe, F. P., Teles, F. B., Rivanor, R. L. D. C., de Sousa, C. N. S., Medeiros, I. D. S., de Queiroz, I. N. L., Figueira-Mansur, J., Mota, É. F., Mohana‐Borges, R., et al. (2022) · Algal Research · doi:10.1016/j.algal.2022.102715 · Cited by 17

Confounder or Confederate? The Interactions Between Drugs and the Gut Microbiome in Psychiatric and Neurological Diseases

Michaelis, L., Berg, L., & Maier, L. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.06.004 · Cited by 20

Role of Inflammation in Psychiatric Disorders

Jeon, S. W., Yoon, H.-K., & Kim, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9721-0_24 · Cited by 19

Thymoquinone improves behavioral and biochemical deficits in hepatic encephalopathy induced by thioacetamide in rats

Hajipour, S., Farbood, Y., Dianat, M., Rashno, M. M., Khorsandi, L. S., & Sarkaki, A. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135617 · Cited by 17

Tetracyclines, a promise for neuropsychiatric disorders: from adjunctive therapy to the discovery of new targets for rational drug design in psychiatry

Filho, A. J. M. C., Mottin, M., Soares, M. V.-R., Jucá, P. M., Andrade, C. H., & Macêdo, D. S. (2021) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000585 · Cited by 17

Nutraceuticals and Physical Activity as Antidepressants: The Central Role of the Gut Microbiota

Zeppa, S. D., Ferrini, F., Agostini, D., Amatori, S., Barbieri, E., Piccoli, G., Sestili, P., & Stocchi, V. (2022) · Antioxidants · doi:10.3390/antiox11020236 · Cited by 20

Licofelone Attenuates LPS-induced Depressive-like Behavior in Mice: A Possible Role for Nitric Oxide

Mousavi, S. E., Saberi, P., Ghasemkhani, N., Fakhraei, N., Mokhtari, R., & Dehpour, A. R. (2018) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/jpps29770 · Cited by 17

The Anti-Inflammatory Potential of Tricyclic Antidepressants (TCAs): A Novel Therapeutic Approach to Atherosclerosis Pathophysiology

Eslami, M., Monemi, M., Nazari, M. A., Azami, M. H., Rad, P. S., Oksenych, V., & Naderian, R. (2025) · Pharmaceuticals · doi:10.3390/ph18020197 · Cited by 18

Doxycycline Used for Control of Transgene Expression has its Own Effects on Behaviors and Bcl-xL in the Rat Hippocampus

Shishkina, G. T., Lanshakov, D. A., Bannova, A. V., Kalinina, T. S., Agarina, N. P., & Дыгало, Н. Н. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0545-6 · Cited by 16

Protective effect of Moringa oleifera Lam. leaf extract against oxidative stress, inflammation, depression, and apoptosis in a mouse model of hepatic encephalopathy

Mahmoud, M. S., El-kott, A. F., AlGwaiz, H. I. M., & Fathy, S. M. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-21453-x · Cited by 15

Hirsutanol A Attenuates Lipopolysaccharide-Mediated Matrix Metalloproteinase 9 Expression and Cytokines Production and Improves Endotoxemia-Induced Acute Sickness Behavior and Acute Lung Injury

Jan, J., Yang, C., Wang, M.-H., Lin, F., Yen, J.-L., Hsieh, I., Khotimchenko, M., Lee, T., & Hsiao, G. (2019) · Marine Drugs · doi:10.3390/md17060360 · Cited by 15

Latroeggtoxin-VI protects nerve cells and prevents depression by inhibiting NF-κB signaling pathway activation and excessive inflammation

Wang, H., Zhai, Y., Lei, Z., Chen, S., Sun, M., Yin, P., Duan, Z., & Wang, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1171351 · Cited by 14

Anti-interleukin-1β antibody prevents the occurrence of repeated restraint stress-induced alterations in synaptic transmission and long-term potentiation in the rat frontal cortex

Bobula, B., Sowa, J. E., & Hess, G. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.08.011 · Cited by 14

Responses to chronic corticosterone on brain glucocorticoid receptors, adrenal gland, and gut microbiota in mice lacking neuronal serotonin

Angoa‐Pérez, M., Zagorac, B., Francescutti, D. M., Theis, K. R., & Kuhn, D. M. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147190 · Cited by 14

Effect of lacosamide on neuroinflammation-mediated seizures comorbid with depression in C57BL/6 mice– Role of kynurenine pathway

Agarwal, S., Vyas, P., Nirwan, N., & Vohora, D. (2021) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2021.108262 · Cited by 13

Involvement of Anti-Inflammatory and Stress Oxidative Markers in the Antidepressant-like Activity of Aloysia citriodora and Verbascoside on Mice with Bacterial Lipopolysaccharide- (LPS-) Induced Depression

Gomes, D. B., Serpa, P. Z., Miorando, D., Zanatta, M. E. D. C., Carteri, C. S., Somensi, L. B., Venzon, L., dos Santos, A. C., França, T. C. S., da Silva, L. M., et al. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1041656 · Cited by 14

Toothbrushing and School Refusal in Elementary School: A Longitudinal Study

Fukuya, Y., Matsuyama, Y., Isumi, A., Doi, S. K., Ochi, M., & Fujiwara, T. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207505 · Cited by 12

Neuroprotective and Antioxidant Effects of Riparin I in a Model of Depression Induced by Corticosterone in Female Mice

Oliveira, I. C. M., Mallmann, A. S. V., Rodrigues, F. A. P., Vidal, L. M. T., Lopes, I. S., Rodrigues, G. C., de Oliveira, N. F., Chaves, R. D. C., Capibaribe, V. C. C., de Carvalho, A. M. R., et al. (2021) · Neuropsychobiology · doi:10.1159/000515929 · Cited by 12

The tetrapartite synapse in neuropsychiatric disorders: Matrix metalloproteinases (MMPs) as promising targets for treatment and rational drug design

Filho, A. J. M. C., Mottin, M., Lós, D. B., Andrade, C. H., & Macêdo, D. S. (2022) · Biochimie · doi:10.1016/j.biochi.2022.07.015 · Cited by 11

Long lasting preventive effects of piperlongumine and a Piper longum extract against stress triggered pathologies in mice

Yadav, V., Chatterjee, S. S., Majeed, M., & Kumar, V. (2015) · Journal of Intercultural Ethnopharmacology · doi:10.5455/jice.20150921010411 · Cited by 11

Investigation of the impact of preconditioning with lipopolysaccharide on inflammation-induced gene expression in the brain and depression-like behavior in male mice

Koga, M., Toda, H., Kinoshita, M., Asai, F., Nagamine, M., Shimizu, K., Kobayashi, Y., Morimoto, Y., & Yoshino, A. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109978 · Cited by 11

Early antibiotic exposure and risk of psychiatric and neurocognitive outcomes: systematic review and meta-analysis

Green, J. E., Wrobel, A. L., Todd, E., Marx, W., Berk, M., Lotfaliany, M., Castle, D. J., Cryan, J. F., Athan, E., Hair, C., et al. (2024) · The British Journal of Psychiatry · doi:10.1192/bjp.2024.121 · Cited by 12

Gut-Microbiome Implications in Opioid Use Disorder and Related Behaviors

Herlihy, B., & Roy, S. (2022) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2022.10311 · Cited by 10

Neuroinflammatory reactions in sickness behavior induced by bacterial infection: Protective effect of minocycline

Mansour, H. A., Hassan, W. A., & Georgy, G. S. (2017) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22020 · Cited by 10

Caffeine alleviate lipopolysaccharide-induced neuroinflammation and depression through regulating p-AKT and NF-κB

Zhang, R., Zhang, L., Du, W., Tang, J., Yang, L., Geng, D., & Cheng, Y. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137923 · Cited by 9

Vanillic acid alleviates lipopolysaccharide-induced anxiety/depression-like behaviors and cerebral oxidative stress in male rats

Vastegani, S. M., Hajipour, S., Sarkaki, A., Farbood, Y., Ghaderi, S., Rashno, M., Jahangiri, H. M., & Khoshnam, S. E. (2022) · Learning and Motivation · doi:10.1016/j.lmot.2022.101811 · Cited by 9

Methanolic Extract of Aerva javanica Leaves Prevents LPS-Induced Depressive Like Behavior in Experimental Mice

Arshad, H. M., Ahmad, F.-U.-D., & Lodhi, A. H. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s383054 · Cited by 11

An Update on the Relationship Between the Gut Microbiome and Obsessive-Compulsive Disorder

Turna, J., Patterson, B. A., & Ameringen, M. V. (2017) · Psychiatric Annals · doi:10.3928/00485713-20171013-01 · Cited by 8

Novel Therapeutic Targets for Major Depressive Disorder

Lazar, M. A., & McIntyre, R. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00034-2 · Cited by 9

What’s around the corner in the niche of psychopharmacotherapy of major depressive disorder?

Moodliar‐Rensburg, S., & Naguy, A. (2019) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2019.09.033 · Cited by 9

Automatically Identifying Sickness Behavior in Grazing Lambs with an Acceleration Sensor

Fan, B., Bryant, R. H., & Greer, A. W. (2023) · Animals · doi:10.3390/ani13132086 · Cited by 8

Neuroprotective Effects of Metformin and Berberine in Lipopolysaccharide‐Induced Sickness‐Like Behaviour in Mice

Kodi, T., Praveen, S., Paka, S. K., Sankhe, R., Gopinathan, A., Nandakumar, K., & Kishore, A. (2024) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/2024/8599268 · Cited by 7

Brain oxidative stress mediates anxiety-like behavior induced by indomethacin in zebrafish: protective effect of alpha-tocopherol

Pinheiro, J. S., Pinheiro, E. F., de Deus, G. R., Saito, G. A., Luz, W. L., Assad, N., Palheta, M. R. D. C., Batista, E. D. J. O., Morais, S., Passos, A. D. C. F., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02661-9 · Cited by 7

Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice

Edem, E. E., Ihaza, B. E., Fafure, A. A., Ishola, A. O., Nebo, K. E., Enye, L. A., & Akinluyi, E. T. (2021) · Drug Metabolism and Personalized Therapy · doi:10.1515/dmpt-2021-0126 · Cited by 7

Zanthoxylum alatum attenuates lipopolysaccharide-induced depressive-like behavior in mice hippocampus

Barua, C. C., Saikia, B., Ren, X., Elancheran, R., Pathak, D., Tamuli, S., & Barua, A. (2018) · Pharmacognosy Magazine · doi:10.4103/pm.pm_606_17 · Cited by 7

Apple cider vinegar attenuates lipopolysaccharide-induced neurobehavioral deficits in mice

Asejeje, F. O., Abiola, M. A., Ben‐Azu, B., Adeosun, A., Ighodaro, O. M., & Ajayi, A. M. (2020) · Nutrire · doi:10.1186/s41110-020-00125-1 · Cited by 6

The antidepressant-like effect of doxycycline is associated with decreased nitric oxide metabolite levels in the prefrontal cortex

Sales, A. J., Joca, S. R. L., Bel, E. A. D., & Guimarães, F. S. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114764 · Cited by 6

Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain.

Er, A., Coşkun, D., Bahçıvan, E., & Dik, B. (2020) · PubMed Central · doi:10.22038/ijbms.2020.45193.10527 · Cited by 6

Sertraline associated with gold nanoparticles reduce cellular toxicity and induce sex-specific responses in behavior and neuroinflammation biomarkers in a mouse model of anxiety

Abelaira, H. M., de Moura, A. B., Cardoso, M. M., Pieri, E. D., Abel, J. S., Luiz, G. P., Sombrio, E. M., Borghezan, L. A., Anastacio, R. S., Cruz, L. A. X., et al. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173661 · Cited by 6

Protective effects of an anti-4-HNE monoclonal antibody against liver injury and lethality of endotoxemia in mice

Qiao, H., Morioka, Y., Wang, D., Liu, K., Gao, S., Wake, H., Ousaka, D., Teshigawara, K., Mori, S., & Nishibori, M. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175702 · Cited by 5

Prophylactic Effects of n-Acethylcysteine on Inflammation-induced Depression-like Behaviors in Mice

Wang, Z., Hu, Q., Tian, C., Wang, R., Jiao, Q., Chen, F., Wu, T., Wang, J., Zhu, Y., Liu, A., et al. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.005 · Cited by 5

THE BENEFITS OF ACTIVE COMPOUNDS IN KALANCHOE PINNATA (LMK) PERS ETHYL ACETATE FRACTION ON LUPUS ARTHRITIS MICE

Indriyanti, N., Soeroso, J., & Khotib, J. (2017) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2017.v10i11.20766 · Cited by 5

Rosiglitazone attenuates lipopolysaccharide-induced depressive-like behavior and cognitive deficits in mice

Stupp, I. J. V., Fraga-Junior, E. B., Doneda, D. L., Taniguti, E. H., Ferreira, Y. S., Berto, B. S. D., de Lima, C. B., Rocha-Junior, C. H., de Lima, E., Rios-Santos, F., et al. (2018) · Journal of Clinical and Molecular Medicine · doi:10.15761/jcmm.1000123 · Cited by 4

Research Progress on Natural Compounds Exerting an Antidepressant Effect through Anti-inflammatory

Yuan, C., Yao, Y., Liu, T., Jin, Y., Yang, C., Loh, X. J., & Li, Z. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210820115259 · Cited by 5

Fluoxetine and Curcumin Prevent the Alterations in Locomotor and Exploratory Activities and Social Interaction Elicited by Immunoinflammatory Activation in Zebrafish: Involvement of BDNF and Proinflammatory Cytokines

Petry, F., Oltramari, A. R., Kuhn, K. Z., Schneider, S. E., Mazon, S. C., Garbinato, C., Aguiar, G. P. S., Kreutz, L. C., de Oliveira, J. V., Siebel, A. M., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00475 · Cited by 5

Doxycycline Ameliorates Schizophrenia-Like Behaviors in Experimental Models in Mice by Targeting Underlying Oxidative Stress

Ben‐Azu, B., Omogbiya, I. A., Aderibigbe, A. O., Umukoro, S., Ajayi, A. M., Eneni, A.-E. O., & Iwalewa, E. O. (2016) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2016.613048 · Cited by 5

Antidepressant-Like Effect of Bauhinia blakeana Dunn in a Neuroinflammation Model in Mice

Herrera-Ruiz, M. L., Santillan‐Urquiza, M. A., Romero‐Cerecero, O., Zamilpa, A., Jiménez‐Ferrer, E., & Tortoriello, J. (2019) · Medical Principles and Practice · doi:10.1159/000502996 · Cited by 5

Neurodevelopmental and Neuropsychiatric Disorders

Traetta, M. E., Filho, A. M. C., Akinluyi, E. T., & Tremblay, M. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_26 · Cited by 4

Epoetin alfa has a potent anxiolytic effect on naive female rats

Çalışkan, H., Koçak, S., & Güneş, E. (2025) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-025-00845-y · Cited by 3

Role of Gastrointestinal Tract (GUT) Health in Reducing Non-communicable Disease Risk

Tripti, T., & Ghosh, J. (2025) · Journal of Comprehensive Health · doi:10.25259/jch_29_2024 · Cited by 3

Enteric nervous system, gut-brain connection and related neurodevelopmental disorders

Alim, E., Gülekon, N., Atalar, K., & Bahçelioğlu, M. (2020) · Anatomy (International Journal of Experimental and Clinical Anatomy) · doi:10.2399/ana.20.008 · Cited by 3

Defining functional states and roles of microglia in neuropsychiatric disorders

Szydłowska, K., Tivanello, R., & Kaminska, B. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1798151 · Cited by 2

Possible Influence of Loxoprofen in Lipopolysaccharide Induced Alterations in Brain Serotonin, Noradrenaline and Dopamine Levels in Chronic Mild Stress Treated Mice

Kundu Smita, S., & Rana, D. G. (2022) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2022.00344 · Cited by 2

From the Drugbank Application to the Novel Drugs: A Pharmacogenomic Summary

Abiyana, S. R., Santoso, S. B., Pribadi, P., Hapsari, W. S., & Syarifuddin, A. (2024) · E3S Web of Conferences · doi:10.1051/e3sconf/202450004002 · Cited by 2

The Correlation of Self Management Behavior with Quality of Life in Patients with Primary Hypertension

Lestari, N. K. Y., & Saraswati, N. L. G. I. (2022) · Indonesian Journal of Global Health Research · doi:10.37287/ijghr.v4i1.839 · Cited by 2

Shared Microglial Mechanisms Underpinning Depression and Fatigue and Their ComorbiditiesPreprint

Filho, A. J. M. C., Macêdo, D. S., de Lucena, D. F., & Maes, M. H. J. (2019) · Preprints.org · doi:10.20944/preprints201902.0029.v1 · Cited by 1

Neuroprotective effects of empagliflozin against lipopolysaccharide-induced depressive-like behavior: Role of TLR4 signaling pathway in modulating neuroinflammation and oxidative stress

Borikar, S. P., Bokade, B. A., Jain, S. P., Zore, P. S., Tapre, D. N., Paliwal, N. P., & Shelke, S. P. (2025) · Next research. · doi:10.1016/j.nexres.2025.101210 · Cited by 1

Protective Effect of Minocycline Against Bacterial Infection-Induced Sickness Behavior in Rats

Soliman, M. G., Hanaa-Mansour, A., Hasan, W. A., & Hassaan, N. A. (2015) · Cited by 1

POSSIBLE INFLUENCE OF LOXOPROFEN IN LIPOPOLYSACCHARIDE INDUCED ALTERATIONS IN SUCROSE INTAKE IN CHRONIC MILD STRESS MODEL IN MICE

Kundu Smita, S., & Rana, D. G. (2021) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2021.v14i7.41249 · Cited by 1

Doxycycline reversal of amphetamine-induced mania-like behavior is related to adjusting brain monoamine abnormalities and antioxidant effects in primary hippocampal neurons

Chaves-Filho, A. J. M., Soares, M. V.-R., Jucá, P. M., Oliveira, T. D. Q., Clemente, D. C. D. S., Monteiro, C. E. D. S., Silva, F. G. O., de Aquino, P. É. A., & Macêdo, D. S. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03009-7 · Cited by 1

The relationship between firm life cycle and firm strategies: A systematic review and future direction

Talha, M., Ngo, N.-Q.-N., Ngo, N.-N.-N., Nguyen, T.-L.-A., Nguyen, M.-D., & Nguyen, G.-D. (2024) · Journal of Infrastructure Policy and Development · doi:10.24294/jipd.v8i7.4382 · Cited by 1

Moderating role of live microbe between chronic inflammatory airway disease and depressive symptoms

Li, W., He, Q., Bai, J., Wen, Y., Hu, Z., Deng, Z., & Huang, Q. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1572178 · Cited by 1

Präklinische Einblicke in das Zusammenspiel von Mikrobiota und Verhalten

Schmidtner, A. K., & Neumann, I. D. (2020) · Nervenheilkunde · doi:10.1055/a-1036-4206 · Cited by 1

Role of Interferon-Gamma and Leucine-Rich Repeat Kinase 2 in Stress-Related Pathology

Litteljohn, D. (2016) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2016-11660

Effect of diallyl disulfide on lipopolysaccharide-induced depression-like behavior in micePreprint

Lu, J., He, H., Huang, C. I., & Chen, Z. (2019) · doi:10.21203/rs.2.19757/v1 · Cited by 1

ENVOLVIMENTO DE MECANISMOS DOPAMINÉRGICOS NA ATIVIDADE ANTIDEPRESSIVA DA LEPTINA NO COMPORTAMENTO TIPO-DEPRESSÃO INDUZIDO POR LPS EM CAMUNDONGOS

Cordeiro, R. C. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Expression and regulation of the rate-limiting enzymes of the kynurenine pathway in the mouse brain

Brooks, A. K. (2017) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Evaluation of Antidepressant Activity of Triptolide in Lipopolysaccharide Induced Depressive like Behavior in Experimental Mice

Lei, L., Wu, Y. L., Sheng-qiang, L., Zhao, B., & Liu, Y. (2018) · International Journal of Pharmacology · doi:10.3923/ijp.2018.633.639

Minireview: Prospect of Doxycycline in Systemic Lupus Erythematosus Treatment

Indriyanti, N., & Soeroso, J. (2019) · Journal Of Tropical Pharmacy And Chemistry · doi:10.25026/jtpc.v4i5.173

Prospects for the use of drugs with anti-inflammatory properties for the treatment of depression

Komysheva, N. P., & Shishkina, G. T. (2021) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2021121061124

Metaloproteinases de matriz e depressão: influência genética e impacto clínico

Pereira, S. C. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2021.tde-14042022-125011

Inhibition of Vascular Adhesion Protein 1 Protects Dopamine Neurons From the Effects of Acute Inflammation and Restores Habit Learning in the StriatumPreprint

Becchi, S., Buson, A., & Balleine, B. W. (2021) · Research Square · doi:10.21203/rs.3.rs-691589/v1

R- and S-ketamine abrogate lipopolysaccharide-induced depressive-like behavior through microglial modulation: a differential anti-inflammatory and neurotrophic effect of the enantiomersPreprint

Filho, A. C., Lós, D. B., Soares, M. V.-R., Jucá, P. M., de Queiroz, T., da Silva, F. E. R., Saraiva, K., Silva, A. D. A., Azul, F. V. C. S., Leal, L. K. A. M., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1671211/v1

R- and S-ketamine abrogate lipopolysaccharide-induced depressive-like behavior through microglial modulation: a differential anti-inflammatory and neurotrophic effect of the enantiomersPreprint

Filho, A. J. M. C., Lós, D. B., Soares, M. L., Jucá, P. M., de Queiroz, T., Rodrigues, F. E., Saraiva, K., Silva, A. K., Azul, F. V. C. S., Leal, L. K. A. M., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1671211/v2

N-butanol fraction of Olax subscorpioidea Oliv. (Olacaceae) attenuates lipopolysaccharide-induced depressive-like symptoms in mice.Preprint

Adeoluwa, O. A., Agboola, I., Akinluyi, E. T., Eduviere, A. T., Adeoluwa, G. O., Ajayi, A. M., & Aderibigbe, A. O. (2023) · Research Square · doi:10.21203/rs.3.rs-2022819/v1

Changes in the Midbrain Neurobiological Responses to Lithium Chloride under Inflammatory Conditions

Bannova, A. V., Shishkina, G. T., Komysheva, N. P., & Дыгало, Н. Н. (2023) · Neurochemical Journal · doi:10.1134/s1819712423010026

Associaçao entre microbiota intestinal e transtorno depressivo maior: uma revisão da literatura

Bochi, G. V., & Quincozes, J. A. V. (2021) · Revista Ciência & Humanização do Hospital de Clínicas de Passo Fundo · doi:10.29327/2185320.1.2-10

Delayed effects of antibiotic therapy in endotoxinemia

Kukushkina, E. S., Lebedeva, E. Y., Maystrenko, V. A., & Kudrinskaya, V. M. (2024) · Medical academic journal · doi:10.17816/maj631406

A COMPREHENSIVE REVIEW OF BAUHINIA X BLAKEANA - THE HONG KONG ORCHID TREE

(2025) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2025/14.5.8940

Doxycycline attenuates cognitive impairment, neuroinflammation and oxidative stress in a mouse model of sepsis-associated encephalopathy

Castro, M. L. D. C., Ferreira, F. M., Chagas, C. F., Gomes, S. V., Pereira, R. R., Coelho, A. M., Braga, S. F. P., Coutinho, G. G., Louise, V., Pio, S., et al. (2025) · Pharmacological Research - Reports · doi:10.1016/j.prerep.2025.100072

Additional file 1 of Inhibition of vascular adhesion protein 1 protects dopamine neurons from the effects of acute inflammation and restores habit learning in the striatum

Becchi, S., Buson, A., & Balleine, B. W. (2021) · Figshare · doi:10.6084/m9.figshare.16821686

Genetic evidence for repurposing immunomodulatory drugs for major depressive disorderPreprint

Jesuthasan, J., ter Kuile, A., Roiser, J. P., Carvalho, L. A., Pitman, A., Chopade, S., Finan, C., Schmidt, A. F., & Pingault, J. (2026) · medRxiv · doi:10.64898/2026.02.07.26345798

Repurposing of doxycycline as a novel therapeutic avenue for management of parkinson’s disease

Ali, N. H., Al-Kuraishy, H. M., Hussain, N. R., Al-Gareeb, A. I., Albuhadily, A. K., Waheeb, T. S., & Batiha, G. E. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02156-y

TREM-1 et parodontite : évaluation clinique de l’effet du traitement étiologique parodontal sur les concentrations de TREM-1 soluble et études in vitro de l’impact de P. gingivalis sur l’expression de TREM-1 par des cellules du parodonte

Dubar, M. (2019) · theses.fr (ABES) · doi:10.70675/43c7a81bz993az40dazb75czb1eee52652a1

Effets de l’administration de tétrahydrobioptérine en condition physiologique et pathologique : De la neurobiologie au comportement

Fanet, H. (2018) · theses.fr (ABES) · doi:10.70675/b46d2065zecc9z4e97zae20zf9e2e4fe0c69

Prophylactic Effects of Ghrelin on Behavioral and Biochemical Outcomes in Male Mice Exposed to Lipopolysaccharide-Induced Inflammation

Zandasrar, F., & Alimohammadi, S. (2026) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-026-10824-4

Depression and the Immune Responses

Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_10

Molecular Signaling Pathways in Depression and Neuroinflammation: Focus on New Pathophysiological Proteins and Therapeutic Compounds

Kim, H. J., Kim, J.-H., Son, Y., Kim, J., & Hong, J. H. (2026) · Antioxidants · doi:10.3390/antiox15091195

Determinação dos efeitos da doxiciclina em um modelo de depressão induzido por lipopolissacarídeo em camundongos

Mello, B. S. F. (2012) · Americanae (AECID Library)

Doxycycline at subantimicrobial dose combined with escitalopram reverses depressive-like behavior and neuroinflammatory hippocampal alterations in the lipopolysaccharide model of depression

Mello, B. S. F., Filho, A. J. M. C., Custódio, C. S., Rodrigues, P. D. A., Carletti, J. V., Vasconcelos, S. M. M., de Sousa, F. C. F., Sanders, L. L. O., & Macêdo, D. S. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.083 · Cited by 22

DeterminaÃÃo dos efeitos da doxiciclina em um modelo de depressÃo induzido por lipopolissacarÃdeo em camundongos

Mello, B. S. F. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

The antidepressant-like effect of doxycycline is associated with decreased nitric oxide metabolite levels in the prefrontal cortex

Sales, A. J., Joca, S. R. L., Bel, E. A. D., & Guimarães, F. S. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114764 · Cited by 6

Study of the immunomodulatory effect of different class antidepressants and nitric oxide synthase isoform inhibitors in the lipopolysaccharide-induced depression model

Tomaz, V. D. S. (2019) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)