Cited by 109Child and Adolescent Psychosocial and Emotional DevelopmentAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesResilience and Mental Health

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Emotion dysregulation mediates the relationship between lifetime cumulative adversity and depressive symptomatology

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Abravanel, Benjamin T., Sinha, Rajita·2015·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2014.11.012PMC PMC4308421

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Abstract

Repeated exposure to stressful events across the lifespan, referred to as cumulative adversity, is a potent risk factor for depression. Research indicates that cumulative adversity detrimentally affects emotion regulation processes, which may represent a pathway linking cumulative adversity to vulnerability to depression. However, empirical evidence that emotion dysregulation mediates the relationship between cumulative adversity and depression is limited, particularly in adult populations. We examined the direct and indirect effects of cumulative adversity on depressive symptomatology in a large community sample of adults (n = 745) who were further characterized by risk status: never-depressed (n = 638) and "at-risk" remitted mood-disordered (n = 107). All participants completed the Cumulative Adversity Inventory (CAI), the Difficulties in Emotion Regulation Scale (DERS), and the Center for Epidemiologic Studies Depression Scale (CES-D). Bootstrapped confidence intervals were computed to estimate the indirect effect of emotion dysregulation on the relationship between cumulative adversity and depressive symptomatology and to test whether this indirect effect was moderated by risk status. Emotion dysregulation partially and significantly mediated the relationship between cumulative adversity and depressive symptomatology independent of risk status. Overall, cumulative adversity and emotion dysregulation accounted for 50% of the variance in depressive symptomatology. These findings support the hypothesis that disruption of adaptive emotion regulation processes associated with repeated exposure to stressful life events represents an intrapersonal mechanism linking the experience of adverse events to depression. Our results support the utility of interventions that simultaneously emphasize stress reduction and emotion regulation to treat and prevent depressive vulnerability and pathology.

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Authors: Abravanel, B. T., & Sinha, R.
Affiliations: Yale University (US)
Corresponding author: Sinha, Rajita
ORCID: Sinha, Rajita
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2015-02
Volume: 61
Pages: 89-96
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2014.11.012
PMC: PMC4308421
OpenAlex: W1994490855
Cited by: 109
References: 83
Citations by year: 2026: 11 · 2025: 10 · 2024: 12 · 2023: 14 · 2022: 8 · 2021: 18 · 2020: 13 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 2 · 2015: 2
FWCI: 4.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (DK099039)
Topics: Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Keywords: cumulative adversity, emotional dysregulation, depressive symptoms, depression risk, life events, mediation, emotion regulation, stress reduction intervention, depression prevention
MeSH terms: Adaptation, Psychological, Adult, Depression, Emotions, Female, Humans, Interpersonal Relations, Life Change Events, Male, Personality Inventory, Risk Factors, Social Perception, Young Adult

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Emotion dysregulation mediates the relationship between lifetime cumulative adversity and depressive symptomatology

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