The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Altered gut microbiota profile in patients with generalized anxiety disorder
Abstract
Close relationships have recently been established between gut microbiota and some mental disorders. Here, we performed a systematic comparative analysis of the gut microbiome in patients with generalized anxiety disorder (GAD) and healthy controls (HCs). We first conducted a cross-sectional study of 40 patients with GAD in the active state and 36 HCs. Second, subgroup analysis consisting of 12 antidepressant-naive patients and 22 controls was performed to validate the results. Finally, a prospective study was performed in a subgroup of nine patients with GAD who underwent analysis in the active state of anxiety and in remission. Compared with the HCs, we found markedly decreased microbial richness and diversity, distinct metagenomic composition with reduced short-chain fatty acid (SCFA)-producing bacteria (associated with a healthy status) and overgrowth of bacteria, such as Escherichia-Shigella, Fusobacterium and Ruminococcus gnavus. Unexpectedly, these changes in the genera were not reversed in remissive GAD. This study identified microbiota dysbiosis of gut microbiota in GAD patients, suggesting that targeting the microbiome may be a useful therapeutic and preventive target for GAD.
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The assessment of anxiety states by rating
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Gut–brain axis: How the microbiome influences anxiety and depression
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Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
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The role of microbiome in central nervous system disorders
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Interaction Between Atypical Antipsychotics and the Gut Microbiome in a Bipolar Disease Cohort
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Cited by
The gut microbiota in anxiety and depression—A systematic review
Simpson, C. A., Diaz-Arteche, C., Eliby, D., Schwartz, O. S., Simmons, J. G., & Cowan, C. S. M. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101943 · Cited by 912
The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857
The role of inflammation and the gut microbiome in depression and anxiety
Peirce, J. M., & Alviña, K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24476 · Cited by 466
RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review
Vijay, A., & Valdes, A. M. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00991-6 · Cited by 361
RetractedRuminococcus gnavus : friend or foe for human health
Crost, E. H., Coletto, E., Bell, A., & Juge, N. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad014 · Cited by 335
Metadata
- Authors
- Jiang, H.-Y., Zhang, X., Yu, Z.-H., Zhang, Z., Deng, M., Zhao, J.-H., & Ruan, B.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 104
- Pages
- 130-136
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2884283422
- Cited by
- 408
- References
- 11
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jiang, H.-Y., Zhang, X., Yu, Z.-H., Zhang, Z., Deng, M., Zhao, J.-H., & Ruan, B. (2018). Altered gut microbiota profile in patients with generalized anxiety disorder. Journal of Psychiatric Research. https://doi.org/10.1016/j.jpsychires.2018.07.007
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