The role of microbiome in central nervous system disorders

Wang, Yan; Kasper, Lloyd H.

doi:10.1016/j.bbi.2013.12.015

Cited by 803Gut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders

The role of microbiome in central nervous system disorders

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Wang, Yan, Kasper, Lloyd H.·2014·Brain Behavior and Immunity

DOI 10.1016/j.bbi.2013.12.015PMC PMC4062078

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Abstract

Mammals live in a co-evolutionary association with the plethora of microorganisms that reside at a variety of tissue microenvironments. The microbiome represents the collective genomes of these co-existing microorganisms, which is shaped by host factors such as genetics and nutrients but in turn is able to influence host biology in health and disease. Niche-specific microbiome, prominently the gut microbiome, has the capacity to effect both local and distal sites within the host. The gut microbiome has played a crucial role in the bidirectional gut-brain axis that integrates the gut and central nervous system (CNS) activities, and thus the concept of microbiome-gut-brain axis is emerging. Studies are revealing how diverse forms of neuro-immune and neuro-psychiatric disorders are correlated with or modulated by variations of microbiome, microbiota-derived products and exogenous antibiotics and probiotics. The microbiome poises the peripheral immune homeostasis and predisposes host susceptibility to CNS autoimmune diseases such as multiple sclerosis. Neural, endocrine and metabolic mechanisms are also critical mediators of the microbiome-CNS signaling, which are more involved in neuro-psychiatric disorders such as autism, depression, anxiety, stress. Research on the role of microbiome in CNS disorders deepens our academic knowledge about host-microbiome commensalism in central regulation and in practicality, holds conceivable promise for developing novel prognostic and therapeutic avenues for CNS disorders.

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Communication between the gut and the brain is bidirectional, and the intestinal microbiota can control CNS activity through neural, endocrine, immune, and metabolic mechanisms that may influence behaviours typical of ASD patients.
“However, communication is bidirectional and the intestinal microbiota is able to control the activity of the CNS through neural, endocrine, immune, and metabolic mechanisms that could have a possible influence on behaviours typical of ASD patients. [156].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [156]

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Long-term dietary l-arginine supplementation increases endothelial nitric oxide synthase and vasoactive intestinal peptide immunoexpression in rat small intestine
Veličković, K., Markelic, M. B., Golić, I., Otašević, V., Stančić, A., Janković, A., Vučetić, M., Buzadžić, B., Korać, B., & Korać, A. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0585-8 · Cited by 14 · see citing works

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Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
The far-reaching scope of neuroinflammation after traumatic brain injury
Simon, D. W., McGeachy, M. J., Bayır, H., Clark, R. S. B., Loane, D. J., & Kochanek, P. M. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.13 · Cited by 1,190 · see citing works
The microbiome-gut-brain axis in health and disease
Dinan, T. G., & Cryan, J. F. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.007 · Cited by 1,111 · see citing works
New evidences on the altered gut microbiota in autism spectrum disorders
Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0242-1 · Cited by 1,040 · see citing works
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works
Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: gut microbiota, glial reaction and TLR4/TNF-α signaling pathway
Sun, M.-F., Zhu, Y.-L., Zhou, Z.-L., Jia, X.-B., Xu, Y.-D., Yang, Q., Cui, C., & Shen, Y.-Q. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.005 · Cited by 736 · see citing works
Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress
Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., & Jin, F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.033 · Cited by 651 · see citing works
Development of the gut microbiota in infancy and its impact on health in later life
Tanaka, M., & Nakayama, J. (2017) · Allergology International · doi:10.1016/j.alit.2017.07.010 · Cited by 639 · see citing works
The gut microbiome in human neurological disease: A review
Tremlett, H., Bauer, K. C., Appel‐Cresswell, S., Finlay, B. B., & Waubant, E. (2017) · Annals of Neurology · doi:10.1002/ana.24901 · Cited by 535 · see citing works
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Jafarzadeh-Esfehani, R., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 562 · see citing works
Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496 · see citing works
Autism Spectrum Disorders and the Gut Microbiota
Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484 · see citing works
Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry
Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491 · see citing works
Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota
Li, B., He, Y., Ma, J., Huang, P., Du, J., Cao, L. H., Wang, Y., Xiao, Q., Tang, H., & Chen, S. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.07.002 · Cited by 480 · see citing works
Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02587-2 · Cited by 453 · see citing works
The Gut Microbiota in Immune-Mediated Inflammatory Diseases
Forbes, J. D., Domselaar, G. V., & Bernstein, C. N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01081 · Cited by 430 · see citing works
Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease
Qian, Y., Yang, X., Xu, S., Wu, C., Song, Y., Qin, N., Chen, S.-D., & Xiao, Q. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.016 · Cited by 409 · see citing works
The progress of gut microbiome research related to brain disorders
Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works
Comprehensive description of blood microbiome from healthy donors assessed by 16 S targeted metagenomic sequencing
Païssé, S., Valle, C., Servant, F., Courtney, M., Burcelin, R., Amar, J., & Lelouvier, B. (2016) · Transfusion · doi:10.1111/trf.13477 · Cited by 416 · see citing works
The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder
Srikantha, P., & Mohajeri, M. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092115 · Cited by 400 · see citing works
Gut microbiota in autism and mood disorders
Mangiola, F. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.361 · Cited by 413 · see citing works
Altered gut microbiota profile in patients with generalized anxiety disorder
Jiang, H., Zhang, X., Yu, Z., Zhang, Z., Deng, M., Zhao, J., & Ruan, B. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.07.007 · Cited by 411 · see citing works
Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential
Guo, R., Chen, L., Xing, C., & Liu, T. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.07.026 · Cited by 416 · see citing works
Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts
Bourdeau, R. W., Lee‐Gosselin, A., Lakshmanan, A., Farhadi, A., Kumar, S. R., Nety, S. P., & Shapiro, M. G. (2018) · Nature · doi:10.1038/nature25021 · Cited by 386 · see citing works
Relationship between the gut microbiome and brain function
Mohajeri, M. H., La Fata, G., Steinert, R. E., & Weber, P. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy009 · Cited by 376 · see citing works
Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial
Slykerman, R. F., Hood, F., Wickens, K., Thompson, J. M. D., Barthow, C., Murphy, R., Kang, J., Rowden, J., Stone, P., Crane, J., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.013 · Cited by 422 · see citing works
The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects?
Lopresti, A. L. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx011 · Cited by 376 · see citing works
Bovine Host Genetic Variation Influences Rumen Microbial Methane Production with Best Selection Criterion for Low Methane Emitting and Efficiently Feed Converting Hosts Based on Metagenomic Gene Abundance
Roehe, R., Dewhurst, R. J., Duthie, C.-A., Rooke, J. A., McKain, N., Ross, D. W., Hyslop, J. J., Waterhouse, A., Freeman, T. C., Watson, M., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005846 · Cited by 359 · see citing works
Gut microbiota in early pediatric multiple sclerosis: a case−control study
Tremlett, H. L., Fadrosh, D. W., Faruqi, A. A., Zhu, F., Hart, J., Roalstad, S., Graves, J., Lynch, S. V., & Waubant, E. L. (2016) · European Journal of Neurology · doi:10.1111/ene.13026 · Cited by 347 · see citing works
Gut dysbiosis impairs recovery after spinal cord injury
Kigerl, K. A., Hall, J. C. E., Wang, L., Mo, X. M., Yu, Z., & Popovich, P. G. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151345 · Cited by 338 · see citing works
The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.
Appleton, J. (2018) · Europe PMC (PubMed Central) · Cited by 337 · see citing works
The mutual interplay of gut microbiota, diet and human disease
Illiano, P., Brambilla, R., & Parolini, C. (2020) · FEBS Journal · doi:10.1111/febs.15217 · Cited by 331 · see citing works
Autism spectrum disorders and intestinal microbiota
De Angelis, M., Francavilla, R., Piccolo, M., De Giacomo, A., & Gobbetti, M. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1035855 · Cited by 311 · see citing works
Altered brain-gut axis in autism: comorbidity or causative mechanisms
Mayer, E. A., Padua, D., & Tillisch, K. (2014) · BioEssays · doi:10.1002/bies.201400075 · Cited by 304 · see citing works
Modulatory Effects of Probiotics During Pathogenic Infections With Emphasis on Immune Regulation
Raheem, A., Liang, L., Zhang, G., & Cui, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.616713 · Cited by 315 · see citing works
Interplay between the gut-brain axis, obesity and cognitive function
Agustí, A., García-Pardo, M. P., López-Almela, I., Campillo, I., Maes, M., Romaní-Pérez, M., & Sanz, Y. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00155 · Cited by 294 · see citing works
The Role of Microbiome in Insomnia, Circadian Disturbance and Depression
Li, Y., Hao, Y., Fan, F., & Zhang, B. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00669 · Cited by 294 · see citing works
Probiotics in Medicine: A Long Debate
Stavropoulou, E., & Bezirtzoglou, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02192 · Cited by 297 · see citing works
SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model
Bonfili, L., Cecarini, V., Cuccioloni, M., Angeletti, M., Berardi, S., Scarpona, S., Rossi, G., & Eleuteri, A. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0973-4 · Cited by 277 · see citing works
Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in β-amyloid (1–42) injected rats
Azm, S. A. N., Djazayeri, A., Safa, M., Azami, K., Ahmadvand, B., Sabbaghziarani, F., Sharifzadeh, M. S., & Vafa, M. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0648 · Cited by 262 · see citing works
Effects of obesity on depression: A role for inflammation and the gut microbiota
Schachter, J., Martel, J., Lin, C.-S., Chang, C., Wu, T.-R., Lu, C., Ko, Y., Lai, H., Ojcius, D. M., & Young, J. D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.026 · Cited by 252 · see citing works
Disbiome database: linking the microbiome to disease
Janssens, Y., Nielandt, J., Bronselaer, A., Debunne, N., Verbeke, F., Wynendaele, E., Immerseel, F. V., Vandewynckel, Y., Tré, G. D., & Spiegeleer, B. D. (2018) · BMC Microbiology · doi:10.1186/s12866-018-1197-5 · Cited by 250 · see citing works
The role of nutrition in inflammaging
Giosia, P. D., Stamerra, C. A., Giorgini, P., Jamialahamdi, T., Butler, A. E., & Sahebkar, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101596 · Cited by 250 · see citing works
An analysis of human microbe–disease associations
Ma, W., Zhang, L., Zeng, P., Huang, C., Li, J., Geng, B., Yang, J., Kong, W., Zhou, X., & Cui, Q. (2016) · Briefings in Bioinformatics · doi:10.1093/bib/bbw005 · Cited by 244 · see citing works
C-reactive protein concentrations across the mood spectrum in bipolar disorder: a systematic review and meta-analysis
Fernandes, B. S., Steiner, J., Molendijk, M. L., Dodd, S., Nardin, P., Gonçalves, C.-A., Jacka, F., Köhler, C. A., Karmakar, C., Carvalho, A. F., et al. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30370-4 · Cited by 247 · see citing works
Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice
Reber, S. O., Siebler, P. H., Donner, N. C., Morton, J. T., Smith, D. G., Kopelman, J. M., Lowe, K. R., Wheeler, K. J., Fox, J. H., Hassell, J. E., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600324113 · Cited by 233 · see citing works
Fecal microbiota transplantation broadening its application beyond intestinal disorders
Xu, M.-Q. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i1.102 · Cited by 231 · see citing works
Gut microbiota and autism: key concepts and findings
Ding, H. T., Taur, Y., & Walkup, J. T. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2960-9 · Cited by 232 · see citing works
Nutrition Facts in Multiple Sclerosis
Riccio, P., & Rossano, R. (2015) · ASN NEURO · doi:10.1177/1759091414568185 · Cited by 232 · see citing works
Morphogenesis and maturation of the embryonic and postnatal intestine
Chin, A. M., Hill, D. R., Aurora, M., & Spence, J. R. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.01.011 · Cited by 222 · see citing works
Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice
Savignac, H. M., Couch, Y., Stratford, M., Bannerman, D. M., Tzortzis, G., Anthony, D. C., & Burnet, P. W. J. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.10.007 · Cited by 223 · see citing works
Making Sense of … the Microbiome in Psychiatry
Bastiaanssen, T. F. S., Cowan, C. S. M., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy067 · Cited by 223 · see citing works
Recent Advances of Stimuli-Responsive Polysaccharide Hydrogels in Delivery Systems: A Review
Zhang, Y., Dong, L., Liu, L., Wu, Z., Pan, D., & Liu, L. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01080 · Cited by 218 · see citing works
Gut microbiome in multiple sclerosis: The players involved and the roles they play
Shahi, S. K., Freedman, S. N., & Mangalam, A. K. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1349041 · Cited by 218 · see citing works
Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke
Winek, K., Engel, O., Bäcker‐Koduah, P., Heimesaat, M. M., Fischer, A., Bereswill, S., Dames, C., Kershaw, O., Gruber, A. D., Curato, C., et al. (2016) · Stroke · doi:10.1161/strokeaha.115.011800 · Cited by 214 · see citing works
Interactions of innate and adaptive immunity in brain development and function
Filiano, A. J., Gadani, S. P., & Kipnis, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.050 · Cited by 217 · see citing works
Mind-altering with the gut: Modulation of the gut-brain axis with probiotics
Kim, N., Yun, M., Oh, Y. J., & Choi, H.-J. (2018) · Journal of Microbiology · doi:10.1007/s12275-018-8032-4 · Cited by 210 · see citing works
Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions
Ristori, M. V., Quagliariello, A., Reddel, S., Ianiro, G., Vicari, S., Gasbarrini, A., & Putignani, L. (2019) · Nutrients · doi:10.3390/nu11112812 · Cited by 214 · see citing works
Does the microbiota play a role in the pathogenesis of autoimmune diseases?
McLean, M. H., Dieguez, D., Miller, L. M., & Young, H. A. (2014) · Gut · doi:10.1136/gutjnl-2014-308514 · Cited by 207 · see citing works
Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms
Felice, V. D., Quigley, E. M., Sullivan, A. M., O'Keeffe, G. W., & O'Mahony, S. M. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.03.012 · Cited by 205 · see citing works
Microbiota Signaling Pathways that Influence Neurologic Disease
Cox, L. M., & Weiner, H. L. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0598-8 · Cited by 208 · see citing works
An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling
Wang, Y., Telesford, K. M., Ochoa‐Repáraz, J., Haque-Begum, S., Christy, M., Kasper, E. J., Wang, L., Wu, Y., Robson, S. C., Kasper, D. L., et al. (2014) · Nature Communications · doi:10.1038/ncomms5432 · Cited by 204 · see citing works
The role of the gut microbiota in multiple sclerosis
Correale, J., Hohlfeld, R., & Baranzini, S. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00697-8 · Cited by 207 · see citing works
Links between the microbiome and bone
Hernandez, C. J., Guss, J. D., Luna, M., & Goldring, S. R. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2887 · Cited by 200 · see citing works
Alterations in Circulating Fatty Acid Are Associated With Gut Microbiota Dysbiosis and Inflammation in Multiple Sclerosis
Saresella, M., Marventano, I., Barone, M., Rosa, F. L., Piancone, F., Mendozzi, L., d’Arma, A., Rossi, V., Pugnetti, L., Roda, G., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01390 · Cited by 201 · see citing works
Danger-Associated Molecular Patterns (DAMPs): the Derivatives and Triggers of Inflammation
Patel, S. V. (2018) · Current Allergy and Asthma Reports · doi:10.1007/s11882-018-0817-3 · Cited by 197 · see citing works
Humans as holobionts: implications for prevention and therapy
van de Guchte, M., Blottière, H. M., & Dore, J. M. (2018) · Microbiome · doi:10.1186/s40168-018-0466-8 · Cited by 192 · see citing works
Longitudinal Analysis of Fecal Microbiome and Pathologic Processes in a Rotenone Induced Mice Model of Parkinson’s Disease
Yang, X., Qian, Y., Xu, S., Song, Y., & Xiao, Q. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00441 · Cited by 173 · see citing works
“The gut-brain axis interactions are significantly modulated by the gut microbiota via immune, neural, and endocrine pathways (Wang and Kasper, 2014).”
Background
The Characterization of Novel Tissue Microbiota Using an Optimized 16S Metagenomic Sequencing Pipeline
Lluch, J., Servant, F., Païssé, S., Valle, C., Valière, S., Kuchly, C., Vilchez, G., Donnadieu, C., Courtney, M., Burcelin, R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142334 · Cited by 190 · see citing works
A Review: The Fate of Bacteriocins in the Human Gastro-Intestinal Tract: Do They Cross the Gut–Blood Barrier?
Dicks, L. M. T., Dreyer, L., Smith, C., & Staden, A. D. P. V. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02297 · Cited by 190 · see citing works
Analysis of gut microbiota profiles and microbe-disease associations in children with autism spectrum disorders in China
Zhang, M., Ma, W., Zhang, J., He, Y., & Wang, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-32219-2 · Cited by 188 · see citing works
Alteration of Gut Microbiota and Inflammatory Cytokine/Chemokine Profiles in 5-Fluorouracil Induced Intestinal Mucositis
Li, H., Lŭ, L., Wang, X., Qin, L., Wang, P., Qiu, S., Wu, H., Huang, F., Zhang, B., Shi, H., et al. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00455 · Cited by 184 · see citing works
Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases
Leo, E. E. M., & Campos, M. R. S. (2019) · Nutrition · doi:10.1016/j.nut.2019.110609 · Cited by 188 · see citing works
Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease
Zhu, M., Liu, X., Ye, Y., Yan, X., Cheng, Y., Zhao, L., Chen, F., & Ling, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.937555 · Cited by 177 · see citing works
Gut microbiota and dietary patterns in children with attention-deficit/hyperactivity disorder
Wang, L., Yang, C., Chou, W., Lee, M., Chou, M., Kuo, H., Yeh, Y., Lee, S.-Y., Huang, L., & Li, S. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-019-01352-2 · Cited by 174 · see citing works
The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders
Anand, N., Gorantla, V. R., & Chidambaram, S. B. (2022) · Cells · doi:10.3390/cells12010054 · Cited by 185 · see citing works
Gut microbiota profiles in treatment-naïve children with attention deficit hyperactivity disorder
Jiang, H.-Y., Zhou, Y.-Y., Zhou, G.-L., Li, Y.-C., Yuan, J., Li, X.-H., & Ruan, B. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.03.036 · Cited by 164 · see citing works
Bacterial Metabolites of Human Gut Microbiota Correlating with Depression
Averina, O. V., Zorkina, Y., Yunes, R. А., Kovtun, A. S., Ushakova, V. M., Morozova, A. Y., Kostyuk, G. P., Даниленко, В. Н., & Chekhonin, V. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239234 · Cited by 166 · see citing works
Immune modulation of the brain-gut-microbe axis
Aidy, S. E., Dinan, T. G., & Cryan, J. F. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00146 · Cited by 163 · see citing works
Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish
Davis, D. J., Doerr, H. M., Grzelak, A. K., Busi, S. B., Jašarević, E., Ericsson, A. C., & Bryda, E. C. (2016) · Scientific Reports · doi:10.1038/srep33726 · Cited by 162 · see citing works
Mental health and periodontal and peri‐implant diseases
Ball, J., & Darby, I. B. (2022) · Periodontology 2000 · doi:10.1111/prd.12452 · Cited by 180 · see citing works
On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death
Kell, D. B., & Pretorius, E. (2015) · Integrative Biology · doi:10.1039/c5ib00158g · Cited by 160 · see citing works
Immunological and Clinical Effect of Diet Modulation of the Gut Microbiome in Multiple Sclerosis Patients: A Pilot Study
Saresella, M., Mendozzi, L., Rossi, V., Mazzali, F., Piancone, F., LaRosa, F., Marventano, I., Caputo, D., Felis, G. E., & Clerici, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01391 · Cited by 159 · see citing works
Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives
Chu, F., Shi, M., Lang, Y., Shen, D., Jin, T., Zhu, J., & Cui, L. (2018) · Mediators of Inflammation · doi:10.1155/2018/8168717 · Cited by 159 · see citing works
Can probiotics benefit children with autism spectrum disorders?
Navarro, F., Liu, Y., & Rhoads, J. M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i46.10093 · Cited by 154 · see citing works
Polyphenols and health: Interactions between fibre, plant polyphenols and the gut microbiota
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Authors: Wang, Y., & Kasper, L. H.
Affiliations: Dartmouth College (US)
Corresponding author: Kasper, Lloyd H.
ORCID: Wang, Yan
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2014-05
Volume: 38
Pages: 1-12
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2013.12.015
PMC: PMC4062078
OpenAlex: W1991521547
Cited by: 803
References: 160
Citations by year: 2026: 26 · 2025: 54 · 2024: 58 · 2023: 81 · 2022: 70 · 2021: 73 · 2020: 98 · 2019: 69 · 2018: 77 · 2017: 69 · 2016: 65 · 2015: 41 · 2014: 21
FWCI: 3.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R56AI098282)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: microbiome, central nervous system disorders, gut microbiota, microbiome-gut-brain axis, neuropsychiatric disorders, multiple sclerosis, autism spectrum disorder, depression, anxiety, stress, probiotics, antibiotics
MeSH terms: Animals, Brain, Central Nervous System Diseases, Humans, Gastrointestinal Tract, Microbiota

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