Early prediction of mental health problems following military deployment: Integrating pre- and post-deployment factors in neural network models
Abstract
Military personnel deployed to war zones are at increased risk of mental health problems such as posttraumatic stress disorder (PTSD) or depression. Early pre- or post-deployment identification of those at highest risk of such problems is crucial to target intervention to those in need. However, sufficiently accurate models predicting objectively assessed mental health outcomes have not been put forward. In a sample consisting of all Danish military personnel who deployed to war zones for the first (N = 27,594), second (N = 11,083) and third (N = 5,161) time between 1992 and 2013, we apply neural networks to predict psychiatric diagnoses or use of psychotropic medicine in the years following deployment. Models are based on pre-deployment registry data alone or on pre-deployment registry data in combination with post-deployment questionnaire data on deployment experiences or early post-deployment reactions. Further, we identified the most central predictors of importance for the first, second, and third deployment. Models based on pre-deployment registry data alone had lower accuracy (AUCs ranging from 0.61 (third deployment) to 0.67 (first deployment)) than models including pre- and post-deployment data (AUCs ranging from 0.70 (third deployment) to 0.74 (first deployment)). Age at deployment, deployment year and previous physical trauma were important across deployments. Post-deployment predictors varied across deployments but included deployment exposures as well as early post-deployment symptoms. The results suggest that neural network models combining pre- and early post-deployment data can be utilized for screening tools that identify individuals at risk of severe mental health problems in the years following military deployment.
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The percentage of individuals deployed in a combat unit was highest for the first deployment (32.7%), compared to the second (25.6%) and the third (20.8%) deployment.
“The percentage of indi-viduals deployed in a combat unit was highest for the first deployment (32.7%), compared to the second (25.6%) and the third (20.8%) deploy-”
From Edge AI for Early Detection of Chronic Diseases and the Spread of Infectious Diseases: Opportunities, Challenges, and Future Directions (2023) · cites this paper as [78]
Approximately 95% of participants in the study predicting mental health problems after military deployment were male.
“Approximately 95% of participants were male.”
From Edge AI for Early Detection of Chronic Diseases and the Spread of Infectious Diseases: Opportunities, Challenges, and Future Directions (2023) · cites this paper as [78]
Cites
Chicco, D., & Jurman, G. (2020) · BMC Genomics · doi:10.1186/s12864-019-6413-7 · Cited by 6,143 · see citing works
Combat Duty in Iraq and Afghanistan, Mental Health Problems, and Barriers to Care
Hoge, C. W., Castro, C. A., Messer, S. C., McGurk, D., Cotting, D. I., & Koffman, R. L. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040603 · Cited by 4,778 · see citing works
The Danish National Patient Register
Lynge, E., Sandegaard, J. L., & Rebolj, M. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494811401482 · Cited by 3,968 · see citing works
The Danish National Prescription Registry
Wallach‐Kildemoes, H., Sørensen, H. T., & Hallas, J. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810394717 · Cited by 2,470 · see citing works
The Danish Register of Causes of Death
Helweg‐Larsen, K. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494811399958 · Cited by 1,735 · see citing works
The Danish Psychiatric Central Research Register
Mors, O., Perto, G. P., & Mortensen, P. B. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810395825 · Cited by 1,589 · see citing works
A Meta-Analysis of Risk Factors for Combat-Related PTSD among Military Personnel and Veterans
Xue, C., Ge, Y., Tang, B., Liu, Y., Kang, P., Wang, M., & Zhang, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120270 · Cited by 507 · see citing works
Epidemiology of posttraumatic stress disorder
Atwoli, L., Stein, D. J., Koenen, K. C., & McLaughlin, K. A. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000167 · Cited by 426 · see citing works
Gates, M. A., Holowka, D. W., Vasterling, J. J., Keane, T. M., Marx, B. P., & Rosen, R. C. (2012) · Psychological Services · doi:10.1037/a0027649 · Cited by 283 · see citing works
Quantitative forecasting of PTSD from early trauma responses: A Machine Learning application
Galatzer-Levy, I. R., Karstoft, K.-I., Statnikov, A., & Shalev, A. Y. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.017 · Cited by 195 · see citing works
Self-citationUtzon-Frank, N., Breinegaard, N., Bertelsen, M., Borritz, M., Eller, N. H., Nordentoft, M., Olesen, K., Rod, N. H., Rugulies, R., & Bonde, J. P. (2014) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3420 · Cited by 151 · see citing works
Bridging a translational gap: using machine learning to improve the prediction of PTSD
For members of the Jerusalem Trauma Outreach and Prevention Study (J-TOPS) group, Karstoft, K., Galatzer‐Levy, I. R., Statnikov, A., Li, Z., & Shalev, A. Y. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0399-8 · Cited by 151 · see citing works
Self-citationSchultebraucks, K., Shalev, A. Y., Michopoulos, V., Grudzen, C. R., Shin, S.-M., Stevens, J. S., Maples‐Keller, J. L., Jovanović, T., Bonanno, G. A., ROTHBAUM, B. O., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0951-z · Cited by 130 · see citing works
Schultebraucks, K., Qian, M., Amara, D. A., Dean, K. R., LASKA, E. M., Siegel, C., Gautam, A., Guffanti, G., Hammamieh, R., Misganaw, B., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0789-2 · Cited by 110 · see citing works
Reijnen, A., Rademaker, A. R., Vermetten, E. H. G. J. M., & Geuze, E. (2014) · European Psychiatry · doi:10.1016/j.eurpsy.2014.05.003 · Cited by 97 · see citing works
Warner, C. H., Appenzeller, G. N., Parker, J. R., Warner, C. M., & Hoge, C. W. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10091303 · Cited by 96 · see citing works
Rona, R. J., Hooper, R., Jones, M., Hull, L., Browne, T., Horn, O., Murphy, D., Hotopf, M. H., & Wessely, S. C. (2006) · BMJ · doi:10.1136/bmj.38985.610949.55 · Cited by 94 · see citing works
Leightley, D., Williamson, V., Darby, J., & Fear, N. T. (2018) · Journal of Mental Health · doi:10.1080/09638237.2018.1521946 · Cited by 83 · see citing works
Schultebraucks, K., & Galatzer‐Levy, I. R. (2019) · Journal of Traumatic Stress · doi:10.1002/jts.22384 · Cited by 76 · see citing works
Karstoft, K., Statnikov, A., Andersen, S. B., Madsen, T., & Galatzer‐Levy, I. R. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.05.057 · Cited by 72 · see citing works
Self-citationMachine learning methods to predict child posttraumatic stress: a proof of concept study
Saxe, G., Ma, S.-S., Ren, J.-W., & Aliferis, C. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1384-1 · Cited by 72 · see citing works
Papini, S., Pisner, D., Shumake, J., Powers, M. B., Beevers, C. G., Rainey, E. E., Smits, J. A. J., & Warren, A. M. (2018) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2018.10.004 · Cited by 70 · see citing works
Rona, R. J., Burdett, H. J., Khondoker, M. R., Chesnokov, M., Green, K., Pernet, D., Jones, N., Greenberg, N. L., Wessely, S. C., & Fear, N. T. (2017) · The Lancet · doi:10.1016/s0140-6736(16)32398-4 · Cited by 68 · see citing works
Predicting Posttraumatic Stress Disorder Risk: A Machine Learning Approach
Wshah, S., Skalka, C., & Price, M. (2019) · JMIR Mental Health · doi:10.2196/13946 · Cited by 57 · see citing works
Ziobrowski, H. N., Kennedy, C. J., Ustun, B., House, S. L., Beaudoin, F. L., An, X., Zeng, D., Bollen, K. A., Petukhova, M. V., Sampson, N. A., et al. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.2427 · Cited by 44 · see citing works
Cakmak, A. S., Alday, E. A. P., Poian, G. D., Rad, A. B., Metzler, T. J., Neylan, T. C., House, S. L., Beaudoin, F. L., An, X., Stevens, J. S., et al. (2021) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2021.3053909 · Cited by 35 · see citing works
Predicting Posttraumatic Stress Disorder Among Survivors of Recent Interpersonal Violence
Morris, M. C., Sánchez‐Sáez, F., Bailey, B., Hellman, N. M., Williams, A., Schumacher, J. A., & Rao, U. (2020) · Journal of Interpersonal Violence · doi:10.1177/0886260520978195 · Cited by 31 · see citing works
Positive Predictive Values and Potential Success of Suicide Prediction Models
Simon, G. E., Shortreed, S. M., & Coley, R. Y. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.1516 · Cited by 26 · see citing works
Advances and Controversies in Military Posttraumatic Stress Disorder Screening
Lee, D. J., Warner, C. H., & Hoge, C. W. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0467-7 · Cited by 23 · see citing works
Rosellini, A. J., Stein, M. B., Benedek, D. M., Bliese, P. D., Chiu, W. T., Hwang, I. H., Monahan, J. T., Nock, M. K., Sampson, N. A., Street, A. E., et al. (2018) · Depression and Anxiety · doi:10.1002/da.22807 · Cited by 21 · see citing works
A Machine Learning Approach to Predicting New‐onset Depression in a Military Population
Sampson, L., Jiang, T., Gradus, J. L., Cabral, H., Rosellini, A. J., Calabrese, J. R., Cohen, G. H., Fink, D. S., King, A. P. J., Liberzon, I., et al. (2021) · Psychiatric Research and Clinical Practice · doi:10.1176/appi.prcp.20200031 · Cited by 21 · see citing works
Self-citationPersonal life events—a promising dimension for psychiatry in electronic health records
Weissman, M. M., Pathak, J., & Talati, A. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.3217 · Cited by 16 · see citing works
Karstoft, K., Andersen, S. B., & Nielsen, A. B. S. (2017) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12360 · Cited by 14 · see citing works
Self-citationKarstoft, K., Nielsen, T., & Nielsen, A. B. S. (2018) · European Journal of Psychotraumatology · doi:10.1080/20008198.2018.1487224 · Cited by 12 · see citing works
Self-citationKarstoft, K., Nielsen, T., & Nielsen, A. B. S. (2019) · Behavioral Medicine · doi:10.1080/08964289.2019.1676192 · Cited by 12 · see citing works
Self-citationKarstoft, K., Nielsen, A. B. S., & Nielsen, T. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1326798 · Cited by 9 · see citing works
Self-citationKarstoft, K., Tsamardinos, I., Eskelund, K., Andersen, S. B., & Nissen, L. R. (2020) · JMIR Medical Informatics · doi:10.2196/17119 · Cited by 9 · see citing works
Self-citationNissen, L. R., Tsamardinos, I., Eskelund, K., Gradus, J. L., Andersen, S. B., & Karstoft, K. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.04.010 · Cited by 6 · see citing works
Self-citationTalbott, J. A. (2012) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/j.ypsy.2011.08.084 · Cited by 3 · see citing works
Madsen, T., Vedtofte, M. S., Nordentoft, M., Nissen, L. R., & Andersen, S. B. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12736 · Cited by 3 · see citing works
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- Authors
- Karstoft, K.-I., Eskelund, K., Gradus, J. L., Andersen, S. B., & Nissen, L. R.
- Affiliations
- University of Copenhagen (DK)
- Oticon Medical (Denmark) (DK)
- Boston University (US)
- The Danish Veteran Centre (DK)
- Corresponding author
- Karstoft, Karen-Inge
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 163
- Pages
- 109-117
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W4372203539
- Cited by
- 3
- References
- 41
- Citations by year
- 2025: 2 · 2023: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Funders
- Danish Foundation TrygFonden (122623)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
- Health Sciences › Health Professions › Occupational Therapy › Occupational Health and Performance
- Keywords
- military deployment, mental illness, post-traumatic stress disorder, depression, psychotropic drug use, deployment experience, risk screening, neural network model
- MeSH terms
- Military Deployment, Humans, Mental Health, Military Personnel, Risk Factors, Stress Disorders, Post-Traumatic, Neural Networks, Computer
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