The contribution of disease severity, depression and negative affectivity to fatigue in multiple sclerosis: A comparison with ulcerative colitis
Open accessAbstract
Background Fatigue is one of the most common and troubling symptoms of multiple sclerosis (MS) and more severe and disabling than fatigue in other somatic populations. Although fatigue seems MS specific, its pathogenesis is still poorly understood. Objective To study the disease specificity of fatigue in MS by comparing its level, its physical and psychological correlates to those of patients with ulcerative colitis (UC), a peripheral chronic auto-immune disease. We focused on the relative contribution of disease severity, depression and negative affectivity to fatigue in both patient samples. Methods A total of 88 MS and 76 UC patients were included in this cross-sectional study. Fatigue, depression and negative affectivity were assessed respectively with the physical and mental fatigue subscales of the Multidimensional Fatigue Inventory, the depression subscale of the Hospital Anxiety and Depression Scale, and the neuroticism subscale of the Dutch NEO Five-Factor Inventory. The Expanded Disability Status Scale and the Colitis Activity Index were used to measure disease severity in MS and UC patients respectively. Results While levels of both physical and mental fatigue were significantly higher in MS patients than in UC patients, there were no group differences in the contribution of disease severity, depression and negative affectivity to both physical and mental fatigue. Conclusion Although levels of fatigue are higher for MS patients when compared with UC patients, the correlates of fatigue do not indicate MS specificity. As such our results support a transdiagnostic approach to fatigue in MS.
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Of 17 studies assessing depression, 10 showed statistically significant differences between IBD and other medically ill cohorts.
“Of the 17 studies assessing depression, 10 showed statistically significant differences between IBD and other medically ill cohorts (17, 21, 67, 68, 70, 71, 73-75, 77).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [67]
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SPINHOVEN, P., ORMEL, J., SLOEKERS, P. P. A., KEMPEN, G. I. J. M., SPECKENS, A. E. M., & HEMERT, A. M. V. (1997) · Psychological Medicine · doi:10.1017/s0033291796004382 · Cited by 2,158 · see citing works
The impact of fatigue on patients with multiple sclerosis
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Depression in multiple sclerosis: a review
Siegert, R. J. (2005) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.054635 · Cited by 718 · see citing works
Fatigue in multiple sclerosis and its relationship to depression and neurologic disability
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Longitudinal correlates of fatigue in multiple sclerosis.
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Stress Management for Multiple Sclerosis Patients
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“With regard to depression, our findings are in line with two available intervention studies that suggest that fatigue is caused by depression [48,49].”
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Mikocka-Walus, A., Knowles, S. R., Keefer, L., & Graff, L. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000620 · Cited by 567 · see citing works
- Authors
- Bol, Y., Duits, A. A., Vertommen-Mertens, C. E. R., Hupperts, R. M. M., Romberg-Camps, M. J. L., Verhey, F. R. J., & Vlaeyen, J. W. S.
- Affiliations
- Maastricht University Medical Centre (NL)
- Zuyderland Medisch Centrum (NL)
- Maastricht University (NL)
- Corresponding author
- Bol, Yvonne
- ORCID
- Venue
- Journal of Psychosomatic Research
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 69
- Issue
- 1
- Pages
- 43-49
- ISSN
- 0022-3999 (ISSN-L)
- OpenAlex
- W2144494710
- Cited by
- 28
- References
- 6
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 7 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Psychosomatic Research (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Lirias (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- Universiteit Maastricht
- Örebro Universitet
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- fatigue, multiple sclerosis, ulcerative colitis, disease severity, depression, negative affectivity, neuroticism, physical fatigue, mental fatigue, transdiagnostic approach, chronic autoimmune disease
- MeSH terms
- Adult, Anxiety Disorders, Colitis, Ulcerative, Depressive Disorder, Disability Evaluation, Fatigue, Mental Fatigue, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Personality Inventory, Psychometrics, Severity of Illness Index, Sick Role, Young Adult
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