The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
Regulatory T cells and other leukocytes in the pathogenesis of endometriosis
Abstract
Endometriosis is a common and puzzling gynaecological condition which shows a great deal of variability between women. It affects up to 15% of all women of reproductive age. There is a strong familial component, but the aetiology and pathogenesis are still uncertain. Endometriosis is an 'inflammatory' condition with substantial numbers of leukocytes recruited into the lesion sites. There is increasing evidence to demonstrate marked changes in numbers and functions of these leukocytes in the eutopic endometrium and peritoneal fluid as well as in the lesions. We hypothesise that endometriosis is primarily an endometrial disease with underlying genetic disturbances which lead to a number of major molecular changes in function, enhancing the likelihood that viable fragments of endometrial tissue will pass through the fallopian tubes and attach and grow on the peritoneum. We have demonstrated disturbances in the populations of T cells, B cells, mast cells, dendritic cells and macrophages within the endometrium and ectopic lesions, and are intrigued by the potential for changes in regulatory T cells to influence disease establishment and progression. Interestingly, we have shown that in endometriosis, naturally occurring FOXP3+ regulatory T cells fail to undergo the expected decline in number during the secretory phase, which may account for a decreased ability of newly recruited leukocytes to initiate effective immune responses against viable endometrial fragments, permitting their survival and subsequent establishment. To better understand the pathogenesis of endometriosis, we must learn about how the immune system recognises this disease and how the endometrial immune response is regulated.
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“There is increasing evidence for marked changes in numbers and functions of leukocytes in the eutopic endometrium, peritoneal fluid, and in endometriotic lesions.68”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [68]
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Abramiuk, M., Grywalska, E., Małkowska, P., Sierawska, O., Hrynkiewicz, R., & Niedźwiedzka‐Rystwej, P. (2022) · Cells · doi:10.3390/cells11132028 · Cited by 231
Ahn, S. H., Edwards, A. K., Singh, S. S., Young, S. L., Lessey, B. A., & Tayade, C. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501138 · Cited by 208
Anti-inflammatory cytokines in endometriosis
Zhou, W., Yang, H., Shao, J., Mei, J., Chang, K., Zhu, R., & Li, M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03056-x · Cited by 198
Antioxidant supplementation reduces endometriosis-related pelvic pain in humans
Santanam, N., Kavtaradze, N., Murphy, A. A., Dominguez, C. E., & Parthasarathy, S. (2012) · Translational research · doi:10.1016/j.trsl.2012.05.001 · Cited by 176
Rogers, P. A. W., D’Hooghe, T. M., Fazleabas, A., Giudice, L. C., Montgomery, G. W., Petraglia, F., & Taylor, R. N. (2013) · Reproductive Sciences · doi:10.1177/1933719113477495 · Cited by 154
Metadata
- Authors
- Berbic, M., & Fraser, I. S.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Fraser, I.S.
- Venue
- Journal of Reproductive Immunology
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 88
- Issue
- 2
- Pages
- 149-155
- ISSN
- 0165-0378 (ISSN-L)
- OpenAlex
- W2048798995
- Cited by
- 135
- References
- 52
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 12 · 2019: 4 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 14 · 2014: 14 · 2013: 15 · 2012: 8
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Reproductive Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, regulatory T cells, Foxp3, leukocyte recruitment, endometrial immune response, mast cells, dendritic cells, macrophages, B cells, peritoneal fluid, luteal phase, ectopic endometrium, pathogenesis
- MeSH terms
- Animals, Choristoma, Endometriosis, Endometrium, Female, Humans, Inflammation, Pregnancy, Pregnancy, Ectopic, Uterus, T-Lymphocytes, Regulatory, Forkhead Transcription Factors
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