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Cited by 154Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France

Open access
Rogers, Peter A. W., D’Hooghe, Thomas M., Fazleabas, Asgerally, Giudice, Linda C., Montgomery, Grant W., Petraglia, Felice, Taylor, Robert N.·2013·Reproductive Sciences
DOI 10.1177/1933719113477495PMC PMC3635070
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Abstract

Endometriosis, defined as estrogen-dependent lesions containing endometrial glands and stroma outside the uterus, is a chronic and often painful gynecological condition that affects 6% to 10% of reproductive age women. Endometriosis has estimated annual costs of US $12 419 per woman (approximately €9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity. Decreased quality of life is the most important predictor of direct health care and total costs. It has been estimated that there is a mean delay of 6.7 years between onset of symptoms and a surgical diagnosis of endometriosis, and each affected woman loses on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working. To encourage and facilitate research into this debilitating disease, a consensus workshop to define future directions for endometriosis research was held as part of the 11th World Congress on Endometriosis in September 2011 in Montpellier, France. The objective of this workshop was to review and update the endometriosis research priorities consensus statement developed following the 10th World Congress on Endometriosis in 2008.(1) A total of 56 recommendations for research have been developed, grouped under 6 subheadings: (1) diagnosis, (2) classification and prognosis, (3) clinical trials, treatment, and outcomes, (4) epidemiology, (5) pathophysiology, and (6) research policy. By producing this consensus international research priorities statement, it is the hope of the workshop participants that researchers will be encouraged to develop new interdisciplinary research proposals that will attract increased funding support for work on endometriosis.

AI snapshot

Written from the paper’s full text.

TL;DR

This workshop report updates the 2008 consensus research priorities for endometriosis from the 2011 World Congress, producing 56 recommendations across six domains. It summarizes background burden data and expert recommendations for diagnosis, classification, clinical trials, epidemiology, pathophysiology, and research policy.

Key findings

  • Endometriosis affects an estimated 6% to 10% of reproductive-age women; annual costs are estimated at US $12,419 per woman (approximately €9,579), comprising one-third direct health care costs and two-thirds productivity loss, with a mean 6.7-year delay between symptom onset and surgical diagnosis and an average 10.8 hours of work lost weekly.
  • Between the 2008 and 2011 World Congress meetings, 3,176 new endometriosis publications were recorded on PubMed, a 21.5% increase over the total number published prior to 2008; major contributions included the first two genome-wide association studies and ongoing nerve fiber work.
  • The workshop developed 56 research recommendations grouped under 6 subheadings: diagnosis; classification and prognosis; clinical trials, treatment, and outcomes; epidemiology; pathophysiology; and research policy.
  • Recommendations emphasize noninvasive biomarkers, imaging advances, better classification/prognostic tools, adequately powered multicenter randomized controlled trials with quality-of-life and live-birth outcomes, pain mechanisms, genetic/environmental/diet/BMI research, inflammation/oxidative stress/neuroangiogenesis/stem cells/apoptosis/miRNAs, and biobanks/registries/multidisciplinary approaches.

Methods

  • Consensus workshop held at the 11th World Congress on Endometriosis in September 2011 in Montpellier, France, convened by the World Endometriosis Society and World Endometriosis Research Foundation to review and update the 2008 consensus statement.
  • 58 participants from 19 countries attended; the meeting used 6 moderated sessions, with each moderator reviewing progress, discussing whether 2008 recommendations needed updating, leading discussion, and producing a written summary incorporated into the final report.
  • Narrative synthesis of expert discussion and literature; no primary data collection or systematic review methods are described.

Limitations

  • Stated limitations: Not stated in the paper.
  • Evident from text: this is a consensus workshop report; the recommendations are described as “by no means proscriptive” and are based on expert discussion rather than primary empirical testing.
  • Evident from text: many recommendations call for larger, well-designed, adequately powered studies and validation, indicating evidence gaps and limitations in the existing literature.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1177/1933719113477495

Cites

128 of 128 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 158 cited sources checked · 0 supported · 0 flagged

  • Findingown data

    A number of emerging endometriosis research fields had significantly increased publication rates, including stem cells, proteomics, genomics, angiogenesis, vasculogenesis, genetics, and inflammation.

    “although a number of emerging endometriosis research fields had significantly increased publication rates including stem cells, proteomics, genomics, angiogenesis, vasculogenesis, genetics, and inflammation.”
    Quote in the paperNot a substantial claim
  • Findingown data

    Between 2008 and 2011, 3176 new scientific publications on endometriosis were recorded on PubMed.

    “Between the 2008 and 2011 WCE meetings, a total of 3176 new scientific publications on endometriosis were recorded on PubMed.”
    Quote in the paperNot a substantial claim
  • Findingown data

    The vast majority of publications were in established areas of endometriosis research, including etiology, surgery, histology, pathology, pain, cancer, and fertility.

    “The vast majority of the publications were in established areas of endometriosis research, including etiology, surgery, histology, pathology, pain, cancer, and fertility”
    Quote in the paperSubstantial claim
  • Findingown data

    The 3176 new publications represent a 21.5% increase in the total number of scientific papers published prior to 2008 in the field.

    “This represents a 21.5% increase in the total number of scientific papers published prior to 2008 in the field”
    Quote in the paperNot a substantial claim
  • Findingcitation

    The 2011 World Congress of Endometriosis meeting attached significant priority to the need for research on all aspects of pain, including basic mechanisms, classification, and treatment.

    “One area of research need that was repeatedly highlighted at the 2011 meeting was work on all aspects of pain.34”
    • Also stated in: § Discussion · plain
      “The meeting recognized the impact that pain has on many women with endometriosis and attached significant priority to the need for research on all aspects of pain, including basic mechanisms, classification, and treatment.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [34] Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. source

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  • Classified as probably not a substantial claim. 21
  • May combine two claims. 39

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Endometriosis affects an estimated 6% to 10% of women in the reproductive age group.

    “Endometriosis affects an estimated 6% to 10% of women in the reproductive age group.3”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [3] Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am. 1997;24(2):235–258. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Endometriosis has estimated annual costs of US $12,419 per woman (approximately €9579), comprising one-third direct health care costs and two-thirds loss of productivity.

    “estimated annual costs of US $12 419 per woman (approximately €9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity.6”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [6] Simoens S, Dunselman G, Dirksen C, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292–1299. source

      Not checked in the free run.

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    Premisenone given

    The ENZIAN classification system does not appear to be widely used.

    “However, this classification system does not appear to be widely used.”
    Quote in the paperNot a substantial claim

  • May combine two claims.

    Premisecitation

    Oral CHM may have a better overall treatment effect than danazol; it may be more effective in relieving dysmenorrhea and shrinking adnexal masses when used in conjunction with a CHM enema.

    “Oral CHM may have a better overall treatment effect than danazol; it may be more effective in relieving dysmenorrhea and shrinking adnexal masses when used in conjunction with a CHM enema.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [37] Flower A, Liu JP, Lewith G, Little P, Li Q. Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev. 2012;5:CD006568.

      Not checked in the free run.

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    Premisecitation

    Endometriosis occurs in adolescents, and presenting symptoms may vary from those seen in adult women with the disease.

    “Endometriosis occurs in adolescents, and presenting symptoms may vary from those seen in adult women with the disease.38”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [38] Laufer MR, Sanfilippo J, Rose G. Adolescent endometriosis: diagnosis and treatment approaches. J Pediatr Adolesc Gynecol. 2003;16(suppl 3):S3–S11. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Different techniques for diagnostic and preoperative imaging of endometriosis are being explored, including ultrasound, computed tomography, and magnetic resonance imaging.

    “Different techniques for diagnostic and preoperative imaging of endometriosis are being explored, including ultrasound, computed tomography, and magnetic resonance imaging.21”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [21] Chamie LP, Blasbalg R, Pereira RM, Warmbrand G, Serafini PC. Findings of pelvic endometriosis at transvaginal us, mr imaging, and laparoscopy. Radiographics. 2011;31(4):E77–E100. source

      Not checked in the free run.

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    Premisecitation

    The ENZIAN classification system is a refinement of the rAFS/rASRM criteria, developed to describe more severe disease.

    “A refinement of the rAFS/rASRM criteria is the ENZIAN classification system, developed to describe more severe disease.25”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [25] Tuttlies F, Keckstein J, Ulrich U, et al. [ENZIAN-score, a classification of deep infiltrating endometriosis]. Zentralbl Gynakol. 2005;127(5):275–281. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Loss of work productivity translates into significant costs, ranging from US $208 in Nigeria to US $23,712 in Italy per woman per year.

    “Loss of work productivity translated into significant costs, ranging from US $208 in Nigeria to US $23 712 in Italy per woman per year.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [7] Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373 e368. source

      Not checked in the free run.

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    Premisecitation

    Based on a review of best available evidence, pain recurrence and reoperation rates after conservative surgery for symptomatic endometriosis are high and probably underestimated.

    “Based on a review of best available evidence, pain recurrence and reoperation rates after conservative surgery for symptomatic endometriosis are high and probably underestimated.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [33] Vercellini P, Crosignani PG, Abbiati A, Somigliana E, Vigano P, Fedele L. The effect of surgery for symptomatic endometriosis: the other side of the story. Hum Reprod Update. 2009;15(2):177–188. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    The state of advancement and the results of novel treatments studied in registered trials have recently been reviewed.

    “The state of advancement and the results of novel treatments studied in registered trials (www.ClinicalTrials.gov)have recently been reviewed.36”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [36] Streuli I, de Ziegler D, Borghese B, Santulli P, Batteux F, Chapron C. New treatment strategies and emerging drugs in endometriosis[published online march 23, 2012]. Expert Opin Emerg Drugs. 2012. source

      Not checked in the free run.

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    Premisecitation

    The EFI is a simple, robust, and validated clinical tool that provides reassurance to those patients with good prognoses and avoids wasting time and treatment for those with poor prognoses.

    “The EFI is a simple, robust, and validated clinical tool that provides reassurance to those patients with good prognoses and avoids wasting time and treatment for those with poor prognoses.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [27] Adamson GD, Pasta DJ. Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril. 2010;94(5):1609–1615. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisenone given

    In China, treatment of endometriosis using Chinese herbal medicine (CHM) is routine, and considerable research into the role of CHM in alleviating pain, promoting fertility, and preventing relapse has taken place.

    “In China, treatment of endometriosis using Chinese herbal medicine (CHM) is routine, and considerable research into the role of CHM in alleviating pain, promoting fertility, and preventing relapse has taken place.”
    Quote in the paperNot a substantial claim

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    Premisecitation

    Genetic and environmental factors contribute to endometriosis risk and the disease is inherited as a complex trait.

    “Genetic and environmental factors contribute to endometriosis risk and the disease is inherited as a complex trait.[41][42][43][44][45]”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [41][42][43][44][45]

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    Premisenone given

    Methodological drawbacks limit considerably the validity of observational, noncomparative studies on the effect of laparoscopy, identifying the need for prospective, multicenter randomized controlled trials.

    “Methodological drawbacks limit considerably the validity of observational, noncomparative studies on the effect of laparoscopy, identifying the need for prospective, multicenter randomized controlled trials.”
    Quote in the paperSubstantial claim

  • May combine two claims.

    Premisenone given

    These classifications are restricted to a limited number of criteria and are not particularly valuable for predicting many parameters needed for clinical management, including pain or fertility outcomes.

    “However, these classifications are restricted to a limited number of criteria and are not particularly valuable for predicting many of the parameters needed for clinical management, including pain or fertility outcomes.”
    Quote in the paperSubstantial claim

  • Classified as probably not a substantial claim.

    Premisecitation

    The authors of that systematic review concluded that larger studies in well-defined populations are required to determine the true usefulness of endometrial biomarkers.

    “However, the authors concluded that larger studies in well-defined populations are required to determine their true usefulness.18”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [18] May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endometrial alterations in endometriosis: a systematic review of putative biomarkers. Hum Reprod Update. 2011;17(5):637–653. source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Premisecitation

    The authors of that Cochrane review concluded that post-surgical administration of CHM may have comparable benefits to gestrinone but with fewer side effects.

    “The authors concluded that post-surgical administration of CHM may have comparable benefits to gestrinone but with fewer side effects.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [37] Flower A, Liu JP, Lewith G, Little P, Li Q. Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev. 2012;5:CD006568.

      Not checked in the free run.

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    Premisecitation

    There is a paucity of data on long-term outcomes and little data on cost-effectiveness and QoL for diagnostic laparoscopy.

    “Furthermore, there is a paucity of data on longterm outcomes and little data on cost-effectiveness and QoL.16”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [16] Hori Y. Diagnostic laparoscopy guidelines: This guideline was prepared by the SAGES Guidelines Committee and reviewed and approved by the Board of Governors of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), November 2007. Surg Endosc. 2008;22(5):1353–1383. source

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    Premisecitation

    The American Association of Gynecologic Laparoscopists is currently developing a categorization system that will be more focused on pain.

    “Currently, The American Association of Gynecologic Laparoscopists is developing a categorization system that will be more focused on pain.26”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [26] Adamson GD. Endometriosis classification: an update. Curr Opin Obstet Gynecol. 2011;23(4):213–220. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisenone given

    Current treatment options for women with endometriosis-associated pain and/or infertility include surgery, medical treatment, alternative therapies, and assisted reproduction.

    “Current treatment options for women with endometriosisassociated pain and/or infertility include surgery, medical treatment, alternative therapies, and assisted reproduction.”
    Quote in the paperNot a substantial claim

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Each affected woman loses on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working.

    “Each affected woman lost on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [7] Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373 e368. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Studies in Australian twins, the Icelandic population, and rhesus macaques provide strong evidence for a genetic contribution to endometriosis, with heritability estimated to be around 50%.

    “However, studies in Australian twins, 45 in the Icelandic population, 43 and in rhesus macaques 49 provide strong evidence for a genetic contribution to the disease with the heritability of endometriosis estimated to be around 50%. 45”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites [45] Treloar SA, O’Connor DT, O’Connor VM, Martin NG. Genetic influences on endometriosis in an Australian twin sample. sueT@qimr.edu.au. Fertil Steril. 1999;71(4):701–710. source

      Not checked in the free run.

    • cites [43] Stefansson H, Geirsson RT, Steinthorsdottir V, et al. Genetic factors contribute to the risk of developing endometriosis. Hum Reprod. 2002;17(3):555–559. source

      Not checked in the free run.

    • cites [49] Zondervan KT, Weeks DE, Colman R, et al. Familial aggregation of endometriosis in a large pedigree of rhesus macaques. Hum Reprod. 2004;19(2):448–455. source

      Not checked in the free run.

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    Premisecitation

    Increased total fat consumption was associated with decreased endometriosis risk and increased b-carotene consumption and servings of fruit were associated with increased risk.

    “Increased total fat consumption was associated with decreased endometriosis risk and increased b-carotene consumption and servings of fruit were associated with increased risk.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [53] Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr. 2011;105(3):459–467. source

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    Premisecitation

    Diet plausibly has a role in the etiology of endometriosis through effects at various levels including on steroid hormones; however, few published studies have examined diet and endometriosis risk, resulting in no clear consensus recommendations.

    “Diet plausibly has a role in the etiology of endometriosis through effects at various levels including on steroid hormones; however, few published studies have examined diet and endometriosis risk, 52 resulting in no clear consensus recommendations.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [52] Fjerbaek A, Knudsen UB. Endometriosis, dysmenorrhea and diet–what is the evidence? Eur J Obstet Gynecol Reprod Biol. 2007;132(2): 140–147. source

      Not checked in the free run.

  • May combine two claims.

    Premisenone given

    Autoimmune diseases that may be associated with endometriosis include systemic lupus erythematosus (SLE), hypothyroidism, rheumatoid arthritis, Sjögren syndrome, and multiple sclerosis.

    “Autoimmune diseases that may be associated with endometriosis include systemic lupus erythematosus (SLE), hypothyroidism, rheumatoid arthritis, Sjo ¨gren syndrome, and multiple sclerosis.”
    Quote in the paperNot a substantial claim

  • May combine two claims.

    Premisecitation

    NF-kB-mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells.

    “Human epithelial and stromal endometrial cells express nuclear factor-kappa B (NF-kB) proteins; NF-kB-mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells.63”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [63] Gonzalez-Ramos R, Van Langendonckt A, Defrere S, et al. Involvement of the nuclear factor-kappaB pathway in the pathogenesis of endometriosis. Fertil Steril. 2010;94(6):1985–1994. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    A recent review concluded there is not enough evidence to support the use of anti-inflammatory pentoxifylline in the management of subfertility and relief of pain from endometriosis.

    “However, evidence is mixed on the usefulness of anti-inflammatory agents to treat endometriosis symptoms, with a recent review concluding that there is no enough evidence to support the use of the antiinflammatory pentoxifylline in the management of subfertility and relief of pain from endometriosis.65”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [65] Lu D, Song H, Li Y, Clarke J, Shi G. Pentoxifylline for endometriosis. Cochrane Database Syst Rev. 2012;1: CD007677.

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Dysregulation of ROS production in endometriotic cells correlates with a proproliferative phenotype and may be implicated in the spreading of the disease.

    “The dysregulation of ROS production in endometriotic cells correlates with a proproliferative phenotype and may be implicated in the spreading of the disease.75”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [75] Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F. Reactive oxygen species controls endometriosis progression. Am J Pathol. 2009;175(1):225–234. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    There was also a suggestion of decreased endometriosis risk associated with the consumption of dairy products.

    “There was also a suggestion of decreased endometriosis risk associated with the consumption of dairy products.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [53] Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr. 2011;105(3):459–467. source

      Not checked in the free run.

  • May combine two claims.

    Interpretationreasoning

    Taken together, these reports show that endometriotic lesions can develop their own nerve supply, thereby creating a direct and 2-way interaction between lesions and the CNS.

    “Taken together, these reports show that endometriotic lesions can develop their own nerve supply, thereby creating a direct and 2-way interaction between lesions and the CNS.”
    Quote in the paperSubstantial claim

  • May combine two claims.

    Premisecitation

    Ectopic and eutopic endometrium produce neurotrophic factors, some of which are differentially expressed in cases of endometriosis and could serve as minimally invasive endometriosis biomarkers.

    “Not surprisingly, ectopic and eutopic endometrium produce neurotrophic factors, 83 some of which are differentially expressed in cases of endometrioisis 84 and could serve as minimally invasive endometriosis biomarkers.85”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites [83] Borghese B, Vaiman D, Mondon F, et al. [Neurotrophins and pain in endometriosis]. Gynecol Obstet Fertil. 2010;38(7–8):442–446. source

      Not checked in the free run.

    • cites [84] Browne AS, Yu J, Huang RP, Francisco AM, Sidell N, Taylor RN. Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis. Fertil Steril. 2012;98(3):713–719. source

      Not checked in the free run.

    • cites [85] Giannini A, Bucci F, Luisi S, Cela V, Pluchino N, Merlini S. Brain-derived neurotrophic factor in plasma of women with endometriosis. J Endometriosis. 2010;2(3):144–145. source

      Not checked in the free run.

  • May combine two claims.

    Interpretationcitation

    These results are consistent with clinical and pathological findings observed in patients with endometriosis, compatible with the ectopic endometrium as a source of pain.

    “These results are consistent with clinical and pathological findings observed in patients with endometriosis, compatible with the ectopic endometrium as a source of pain.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [89] Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Significantly increased presence of endometrial cells and altered immune environment has been demonstrated in uterine-draining lymph nodes in the baboon model of induced endometriosis.

    “Significantly increased presence of endometrial cells and altered immune environment has also been demonstrated in uterine-draining lymph nodes in the baboon model of induced endometriosis.99”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [99] Hey-Cunningham AJ, Fazleabas AT, Braundmeier AG, Markham R, Fraser IS, Berbic M. Endometrial stromal cells and immune cell populations within lymph nodes in a nonhuman primate model of endometriosis. Reprod Sci. 2011;18(8):747–754. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    In a rat model of autotransplantation of endometrium to the gastrocnemius muscle, cystic lesions developed within 2 weeks with stromal invasion of the muscle, nociceptor nerve fibers, and neuronal sprouting, and persistent mechanical hyperalgesia at the site of the lesions.

    “In a rat model of autotransplantation of endometrium to the gastrocnemius muscle, cystic lesions developed within 2 weeks with stromal invasion of the muscle, nociceptor nerve fibers, and neuronal sprouting, and persistent mechanical hyperalgesia at the site of the lesions.89”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [89] Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Endometrial biopsy, with detection of nerve fibres, provides a reliability of diagnosis of endometriosis close to the accuracy of laparoscopic assessment by experienced gynecological laparoscopists.

    “It has been reported that endometrial biopsy, with detection of nerve fibres, provides a reliability of diagnosis of endometriosis which is close to the accuracy of laparoscopic assessment by experienced gynecological laparoscopists.86”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [86] Al-Jefout M, Dezarnaulds G, Cooper M, et al. Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study. Hum Reprod. 2009;24(12):3019–3024. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Endometriotic cells display higher endogenous oxidative stress with an increase in ROS production, alterations in ROS detoxification pathways, and a drop in catalase levels.

    “Endometriotic cells display higher endogenous oxidative stress with an increase in ROS production, alterations in ROS detoxification pathways, and a drop in catalase levels.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [75] Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F. Reactive oxygen species controls endometriosis progression. Am J Pathol. 2009;175(1):225–234. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Causality between endometriosis lesions and pain remains an enigma because pain symptoms attributed to endometriosis occur in women without endometriosis and pain symptoms and severity correlate poorly with lesion characteristics.

    “Yet causality remains an enigma, because pain symptoms attributed to endometriosis occur in women without endometriosis and because pain symptoms and severity correlate poorly with lesion characteristics.34”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [34] Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    In a rat autotransplantation model of endometrium to the mesentery, vascularized endometriotic cysts become innervated with sensory and sympathetic fibers, and rats subsequently exhibit vaginal hyperalgesia.

    “In a rat autotransplantation model of endometrium to the mesentery, vascularized endometriotic cysts become innervated with sensory and sympathetic fibers, and rats subsequently exhibit vaginal hyperalgesia.81”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [81] McAllister SL, Dmitrieva N, Berkley KJ. Sprouted innervation into uterine transplants contributes to the development of hyperalgesia in a rat model of endometriosis. PLoS One. 2012;7(2):e31758. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Intralesional, but not contralateral, injection of progesterone was dose-dependently antihyperalgesic as was systemic administration of leuprolide.

    “Intralesional, but not contralateral, injection of progesterone was dose-dependently antihyperalgesic as was systemic administration of leuprolide.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [89] Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Corticotropin-releasing hormone and urocortin are expressed by endometriotic tissue and their deranged expression in endometrium of patients with endometriosis suggests these neuropeptides may also participate in the pathogenesis of endometriosis.

    “Corticotropin-releasing hormone and urocortin are expressed by endometriotic tissue and their deranged expression in endometrium of patients with endometriosis suggests that these neuropeptides may also participate in the pathogenesis of endometriosis.88”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [88] Novembri R, Borges LE, Carrarelli P, et al. Impaired CRH and urocortin expression and function in eutopic endometrium of women with endometriosis. J Clin Endocrinol Metab. 2011;96(4):1145–1150. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Removing cysts before they acquired functional innervation prevented vaginal hyperalgesia from developing, whereas sham cyst removal did not.

    “Removing cysts before they acquired functional innervation prevented vaginal hyperalgesia from developing, whereas sham cyst removal did not.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [81] McAllister SL, Dmitrieva N, Berkley KJ. Sprouted innervation into uterine transplants contributes to the development of hyperalgesia in a rat model of endometriosis. PLoS One. 2012;7(2):e31758. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    In human studies, there is an imbalance between sympathetic and sensory nerve fibres in peritoneal endometriosis as well as an altered modulation of peritoneal fluids from patients with endometriosis on sympathetic and sensory innervation, which might directly be involved in the maintenance of inflammation and pain.

    “In human studies, it has been reported that there is an imbalance between sympathetic and sensory nerve fibres in peritoneal endometriosis as well as an altered modulation of peritoneal fluids from patients with endometriosis on sympathetic and sensory innervation, which might directly be involved in the maintenance of inflammation and pain.82”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [82] Arnold J, Barcena de Arellano ML, Ruster C, et al. Imbalance between sympathetic and sensory innervation in peritoneal endometriosis. Brain Behav Immun. 2012;26(1):132–141. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    In a study of pelvic inflammatory disease in 109 women, 22 at laparoscopy had salpingitis, 19 had adhesions without salpingitis, 20 had endometriosis or ovarian pathology, and 48 no observable abnormality.

    “In a study of pelvic inflammatory disease in 109 women, 22 at laparoscopy had salpingitis, 19 had adhesions without salpingitis, 20 had endometriosis or ovarian pathology, and 48 no observable abnormality.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [119] Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    The endometriotic 70-kDa SRC-1 C-terminal fragment prevents TNF-a-mediated apoptosis in human endometrial epithelial cells and causes the epithelial-mesenchymal transition and the invasion of human endometrial cells that are hallmarks of progressive endometriosis.

    “In contrast to full-length SRC-1, the endometriotic 70-kDa SRC-1 C-terminal fragment prevents TNF-a-mediated apoptosis in human endometrial epithelial cells and causes the epithelial-mesenchymal transition and the invasion of human endometrial cells that are hallmarks of progressive endometriosis.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source

      Not checked in the free run.

  • Classified as probably not a substantial claim. May combine two claims.

    Interpretationcitation

    These differences could influence the expression of angiogenic factors and play a role in the pathogenesis of endometriosis.

    “They conclude that this could influence the expression of angiogenic factors and play a role in the pathogenesis of endometriosis.114”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [114] Ramon LA, Braza-Boils A, Gilabert-Estelles J, et al. micro-RNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod. 2011;26(5):1082–1090. source

      Not checked in the free run.

  • May combine two claims.

    Interpretationcitation

    The results reported for the whole group of women with pain highlight the difficulties in making a precise microbial diagnosis and highlight the need for further investigation into the links between the microbiome, pain, and endometriosis.

    “The results reported for the whole group of women with pain highlight the difficulties in making a precise microbial diagnosis and highlight the need for further investigation into the links between the microbiome, pain, and endometriosis.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [119] Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Endometrial BCL-2 expression may be stimulated by estrogen and downregulated by progesterone.

    “Endometrial BCL-2 expression may be stimulated by estrogen and downregulated by progesterone.110”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [110] Nasu K, Nishida M, Kawano Y, et al. Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis. Reprod Sci. 2011;18(3):206–218. source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Premisecitation

    The authors concluded that greater scrutiny of the preclinical efficacy of models, end points, and experimental designs are needed if the desire of translating novel treatment approaches is to be realized in women with endometriosis.

    “The authors concluded that greater scrutiny of the preclinical efficacy of models, end points, and experimental designs are needed if the desire of translating novel treatment approaches is to be realized in women with endometriosis.115”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [115] Pullen N, Birch CL, Douglas GJ, Hussain Q, Pruimboom-Brees I, Walley RJ. The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies. Hum Reprod Update. 2011;17(6):791–802. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Clonogenic cells and side populations have been identified in human endometrium; these cells are few in number and have the ability to give rise to a variety of differentiated cell types.

    “Clonogenic cells and side populations have been identified in human endometrium; these cells are few in number and have the ability to give rise to a variety of differentiated cell types.101,102”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites [101] Chan RW, Schwab KE, Gargett CE. Clonogenicity of human endometrial epithelial and stromal cells. Biol Reprod. 2004;70(6): 1738–1750. source

      Not checked in the free run.

    • cites [102] Kato K, Yoshimoto M, Kato K, et al. Characterization of side-population cells in human normal endometrium. Human Reproduction. 2007;22(5):1214–1223. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Women with endometriosis are reported to have reduced endometrial apoptosis with increased expression of antiapoptotic and decreased expression of proapoptotic factors.

    “Women with endometriosis are reported to have reduced endometrial apoptosis with increased expression of antiapoptotic and decreased expression of proapoptotic factors.”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [109] Taniguchi F, Kaponis A, Izawa M, et al. Apoptosis and endometriosis. Front Biosci (Elite Ed). 2011;3(2):648–662. source

      Not checked in the free run.

    • cites [110] Nasu K, Nishida M, Kawano Y, et al. Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis. Reprod Sci. 2011;18(3):206–218. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    In endometriosis, there is altered expression of BCL-2 in the eutopic endometrium and thereby fewer apoptotic cells and abnormal survival in ectopic sites.

    “In endometriosis, there is altered expression of BCL-2 in the eutopic endometrium and thereby fewer apoptotic cells and abnormal survival in ectopic sites.109”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [109] Taniguchi F, Kaponis A, Izawa M, et al. Apoptosis and endometriosis. Front Biosci (Elite Ed). 2011;3(2):648–662. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Currently, there are no definitive markers to allow isolation and characterization of endometrial progenitor or stem cells, and it is unknown what drives the recruitment and homing of these cells to eutopic endometrium or ectopic sites.

    “Currently, there are no definitive markers to allow isolation and characterization of endometrial progenitor or stem cells, and it is unknown what drives the recruitment and homing of these cells to eutopic endometrium or ectopic sites.107,108”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites [107] Du H, Taylor HS. Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells. 2007;25(8):2082–2086. source

      Not checked in the free run.

    • cites [108] Sasson IE, Taylor HS. Stem cells and the pathogenesis of endometriosis. Ann N Y Acad Sci. 2008;1127(1):106–115. source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Premisecitation

    Expression levels of miRNAs related to angiogenesis were different in eutopic endometrium from that observed in ovarian endometrioma.

    “Other workers have shown that expression levels of miRNAs related to angiogenesis were different in eutopic endometrium from that observed in ovarian endometrioma.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [114] Ramon LA, Braza-Boils A, Gilabert-Estelles J, et al. micro-RNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod. 2011;26(5):1082–1090. source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Premisecitation

    A systematic review concluded that miRNAs may play an important role in endometriotic lesion development, including regulatory functions associated with hypoxia, inflammation, tissue repair, TGF-b-regulated pathways, cell growth, cell proliferation, apoptosis, extracellular matrix remodeling, and angiogenesis.

    “The authors conclude that miRNAs may play an important role in endometriotic lesion development, including regulatory functions associated with hypoxia, inflammation, tissue repair, TGF-b-regulated pathways, cell growth, cell proliferation, apoptosis, extracellular matrix remodeling, and angiogenesis.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [112] Teague EM, Print CG, Hull ML. The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update. 2010;16(2):142–165. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    In all laparoscopic categories, Ureaplasma spp and Mycoplasma hominis, but not Mycoplasma genitalium, were at least as common in the cervix/vagina as Chlamydia trachomatis and equally frequent in the endometrium.

    “In all laparoscopic categories, Ureaplasma spp and Mycoplasma hominis, but not Mycoplasma genitalium, were at least as common in the cervix/vagina as Chlamydia trachomatis and equally frequent in the endometrium.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [119] Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    Studies focused on gene regulation using transgenic models will provide valuable insights into mechanisms that may contribute to endometriosis.

    “Thus, studies focused on gene regulation using transgenic models will provide valuable insights into mechanisms that may contribute to endometriosis.116,117,111”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites [116] Jeong JW, Lee HS, Lee KY, et al. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 2009;106(21):8677–8682. source

      Not checked in the free run.

    • cites [117] Jeong JW, Lee HS, Franco HL, et al. beta-catenin mediates glandular formation and dysregulation of beta-catenin induces hyperplasia formation in the murine uterus. Oncogene. 2009;28(1):31–40. source

      Not checked in the free run.

    • cites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    The 2011 meeting recognized that pain has an impact on many women with endometriosis.

    “The meeting recognized the impact that pain has on many women with endometriosis and attached significant priority to the need for research on all aspects of pain, including basic mechanisms, classification, and treatment.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [34] Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. source

      Not checked in the free run.

57 of 57

  • The paper relies on this without support.

    Peritoneal oxidative stress is one of the major constituents of the endometriosis-associated inflammatory response.

    “Peritoneal oxidative stress is thought to be one of the major constituent of the endometriosis-associated inflammatory response.”

  • The paper relies on this without support.

    Excessive production of ROS, secondary to peritoneal influx of prooxidants such as heme and iron, may induce cellular damage and increased proinflammatory gene expression through NF-kB activation.

    “Excessive production of reactive oxygen species (ROS), secondary to peritoneal influx of prooxidants such as heme and iron, may induce cellular damage and increased proinflammatory gene expression through NF-kB activation.”

  • The paper relies on this without support.

    ROS are proinflammatory mediators that modulate cell proliferation.

    “The ROS are proinflammatory mediators that modulate cell proliferation.”

  • The paper relies on this without support.

    The presence of unmyelinated sensory nerve fibers in the functional layer of endometrium and increased nerve fiber density in endometrium and myometrium in women with endometriosis suggests a possible role in pain perception.

    “The presence of unmyelinated sensory nerve fibers in the functional layer of endometrium and a significantly increased nerve fiber density in endometrium and myometrium in women with endometriosis suggests a possible role in pain perception.”

  • The paper relies on this without support.

    Angiogenesis and lymphangiogenesis are critical processes in the pathogenesis of endometriosis.

    “Angiogenesis and lymphangiogenesis, or the development of new blood and lymphatic vessels from preexisting ones, are critical processes in the pathogenesis of endometriosis.”

  • The paper relies on this without support.

    Clinical evidence for the efficacy of antiangiogenic endometriosis therapy is still lacking.

    “However, clinical evidence for their efficacy in antiangiogenic endometriosis therapy is still lacking.”

  • The paper relies on this without support.

    Progenitor stem cells have the capacity to generate endometriosis if shed in a retrograde fashion.

    “It is also likely that these same progenitor stem cells have the capacity to generate endometriosis if shed in a retrograde fashion.”

  • The paper relies on this without support.

    Stem cells not of uterine origin may migrate to and cause or contribute to endometriotic lesions.

    “It is also possible that stem cells that are not of uterine origin may migrate to and cause or contribute to endometriotic lesions, both in the peritoneal cavity and in the rarer instances where endometriosis occurs outside of the peritoneal cavity.”

  • The paper relies on this without support.

    Progestins have overall anti-inflammatory activity.

    “Progestins have overall anti-inflammatory activity, and there appears to be progesterone resistance in endometriotic lesions and eutopic endometrium of women with endometriosis.”

  • The paper relies on this without support.

    There is progesterone resistance in endometriotic lesions and eutopic endometrium of women with endometriosis.

    “Progestins have overall anti-inflammatory activity, and there appears to be progesterone resistance in endometriotic lesions and eutopic endometrium of women with endometriosis.”

  • The paper relies on this without support.

    Different progestins have different glucocorticoid and androgenic activity.

    “Given that different progestins have different glucocorticoid and androgenic activity there may be opportunities for modifying treatments to improve outcomes.”

  • The paper relies on this without support.

    Selective progesterone receptor modulators (SPRMs) may have a role in treating endometriosis.

    “Selective progesterone receptor modulators (SPRMs) may also have a role in treating endometriosis, although evidence to support this is lacking to date.”

  • The paper relies on this without support.

    Expression of VEGF-C and VEGF-D and their receptors neuropilin 2 is dysregulated in the endometrium from women with endometriosis.

    “It has recently been demonstrated that expression of the potent lymphangiogenic growth factors VEGF-C and VEGF-D and their receptors neuropilin 2 is dysregulated in the endometrium from women with endometriosis.”

  • The paper relies on this without support.

    Endometriosis organizations, often led by women with endometriosis, have greater credibility with politicians and the general public than scientists or physicians, giving them greater access to media and better effectiveness for educational campaigns.

    “Endometriosis Organizations, which are often led by women with endometriosis, have the ability to raise public awareness about the challenges posed by endometriosis more effectively than scientists or physicians, not the least because they are seen by politicians and the general public to have greater credibility.This gives greater access to media and better effectiveness for educational campaigns”

  • The paper relies on this without support.

    Different endometriosis organizations have been responsible for multimillion dollar outreach campaigns, public service announcement campaigns, numerous outreach mailings, e-mail blitzes, educational outreach videos, books, and brochures.

    “Different endometriosis organizations have been responsible for multimillion dollar outreach campaigns, public service announcement campaigns, numerous outreach mailings, and e-mail blitzes to key stakeholders, educational outreach videos, books, and brochures”

  • The paper relies on this without support.

    These activities have contributed significantly to raising the profile of endometriosis as a disease.

    “This has contributed significantly to raising the profile of endometriosis as a disease”

  • The paper relies on this without support.

    Women with endometriosis often have more persuasive power with government bodies, politicians, and institutions than others.

    “Women with endometriosis often have more persuasive power with government bodies, politicians, and institutions”

  • The paper relies on this without support.

    Personal stories and sharing experience and impact of a disease are more powerful than simply asking for research funds.

    “Personal stories and sharing experience and impact of a disease are more powerful than simply asking for research funds, and women with endometriosis have more political capital as they can represent a significant block of votes”

  • The paper relies on this without support.

    Women with endometriosis have more political capital because they can represent a significant block of votes.

    “Personal stories and sharing experience and impact of a disease are more powerful than simply asking for research funds, and women with endometriosis have more political capital as they can represent a significant block of votes”
19 of 19

Claims other papers make about this one

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Cites

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2 of the 130 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Cakmak H, Guzeloglu-Kayisli O, Kayisli UA, Arici A. Immuneendocrine interactions in endometriosis. Front Biosci (Elite Ed). 2009;1(2):429–443.

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Authors
Rogers, P. A. W., D’Hooghe, T. M., Fazleabas, A., Giudice, L. C., Montgomery, G. W., Petraglia, F., & Taylor, R. N.
Affiliations
  • Royal Women's Hospital (AU)
  • Universitair Ziekenhuis Leuven (BE)
  • Michigan State University (US)
  • University of California, San Francisco (US)
  • QIMR Berghofer Medical Research Institute (AU)
  • University of Siena (IT)
  • Wake Forest University Health Sciences (US)
Corresponding author
Rogers, Peter A. W.
ORCID
Venue
Reproductive Sciences
Publisher
Springer Science and Business Media LLC
Published
2013-05
Volume
20
Issue
5
Pages
483-499
ISSN
  • 1933-7191 (ISSN-L)
  • 1933-7205
DOI
10.1177/1933719113477495
PMC
PMC3635070
OpenAlex
W2103672022
Semantic Scholar
63a4d6c6f314f869bfec6ec5c5d35efc1db55094
Cited by
154
References
130
Citations by year
2026: 1 · 2025: 6 · 2024: 2 · 2023: 9 · 2022: 7 · 2021: 16 · 2020: 15 · 2019: 6 · 2018: 5 · 2017: 16 · 2016: 23 · 2015: 19 · 2014: 28 · 2013: 1
FWCI
28.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Reproductive Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • Use Siena air (University of Siena) (submittedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD055764, U54HD040093, 1U54HD40093, 1U54HD05576, U54HD055787)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
endometriosis, research priorities, consensus statement, endometriosis diagnosis, endometriosis classification, prognosis, clinical trials, treatment outcomes, pathophysiology, science policy, quality of life, economic burden, delayed diagnosis
MeSH terms
Animals, Endometriosis, Female, Forecasting, Humans, Prognosis, Consensus, Biomedical Research

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-10.

Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-10.

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