The role of the endometrial microbiome in embryo implantation and recurrent implantation failure
Abstract
There is a suggested pathophysiology associated with endometrial microbiota in cases where repeated implantation failure of high-quality embryos is observed. However, there is a suspected association between endometrial microbiota and the pathogenesis of implantation failure. However, there is still a lack of agreement on the fundamental composition of the physiological microbiome within the uterine cavity. This is primarily due to various limitations in the studies conducted, including small sample sizes and variations in experimental designs. As a result, the impact of bacterial communities in the endometrium on human reproduction is still a subject of debate. In this discourse, we undertake a comprehensive examination of the existing body of research pertaining to the uterine microbiota and its intricate interplay with the process of embryo implantation.
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A shift in the population of Lactobacillus species has been implicated in diminished endometrial receptivity.
“A shift in the population of Lactobacillus species, for instance, has been implicated in diminished endometrial receptivity [8, 9, 28, 29].”
From Vaginal probiotics as therapeutic adjuncts for improving embryo transfer success rates: a systematic review and meta-analysis (2025) · cites this paper as [29]
Cites
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The vaginal microbiome and preterm birth
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Maleki-Hajiagha, A., Karimi, R., abbasi, S., Emami, N., & Amidi, F. (2025) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-025-07338-0 · Cited by 13 · see citing works
“A shift in the population of Lactobacillus species, for instance, has been implicated in diminished endometrial receptivity [8, 9, 28, 29].”
- Authors
- Rokhsartalab Azar, P., Karimi, S., Haghtalab, A., Taram, S., Hejazi, M., Sadeghpour, S., Pashaei, M. R., Ghasemnejad-Berenji, H., & Taheri-Anganeh, M.
- Affiliations
- Urmia University of Medical Sciences (IR)
- Urmia University (IR)
- Venue
- Journal of Reproductive Immunology
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 162
- Pages
- 104192
- ISSN
- 0165-0378 (ISSN-L)
- OpenAlex
- W4390640380
- Cited by
- 14
- References
- 6
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 1
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Reproductive Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Urmia University of Medical Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- endometrial microbiota, uterine microbiota, embryo implantation, recurrent implantation failure, bacterial communities, human reproduction, endometrium
- MeSH terms
- Endometrium, Female, Humans, Embryo Implantation, Research Design, Uterus, Microbiota
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