The vaginal microbiome and preterm birth
Open accessAbstract
The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in the frequency of preterm birth among populations within countries, and women of African ancestry disproportionately bear the burden of risk in the United States. In the present study, we report a community resource that includes ‘omics’ data from approximately 12,000 samples as part of the integrative Human Microbiome Project. Longitudinal analyses of 16S ribosomal RNA, metagenomic, metatranscriptomic and cytokine profiles from 45 preterm and 90 term birth controls identified harbingers of preterm birth in this cohort of women predominantly of African ancestry. Women who delivered preterm exhibited significantly lower vaginal levels of Lactobacillus crispatus and higher levels of BVAB1, Sneathia amnii, TM7-H1, a group of Prevotella species and nine additional taxa. The first representative genomes of BVAB1 and TM7-H1 are described. Preterm-birth-associated taxa were correlated with proinflammatory cytokines in vaginal fluid. These findings highlight new opportunities for assessment of the risk of preterm birth.
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MOMS-PI identified signatures of higher risk for PTB in women who experienced spontaneous preterm birth at less than 37 weeks of gestation.
“The MOMS-PI team (http://vmc.vcu.edu/momspi) also identified signatures of higher risk for PTB in women who experienced spontaneous preterm birth at less than 37 weeks of gestation50.”
From The Integrative Human Microbiome Project (2019) · cites this paper as [50]
The HMP2 studies together provide information and insights about microbial dynamics, associated human host responses, and microbial inter-relationships.
“These studies, which have now reached the first stage of completion49–51, together provide a wealth of information and insights about not only microbial dynamics, but also associated human host responses and microbial inter-relationships.”
From The Integrative Human Microbiome Project (2019) · cites this paper as [50]
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The Integrative Human Microbiome Project
The Integrative HMP (iHMP) Research Network Consortium, Proctor, L. M., Creasy, H. H., Fettweis, J. M., Lloyd-Price, J., Mahurkar, A., Zhou, W., Buck, G. A., Snyder, M. P., Strauss, J. F., et al. (2019) · Nature · doi:10.1038/s41586-019-1238-8 · Cited by 1,381 · see citing works
Self-citationPrevotella Diversity, Niches and Interactions with the Human Host
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The impact of the gut microbiota on the reproductive and metabolic endocrine system
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The Female Vaginal Microbiome in Health and Bacterial Vaginosis
Chen, X. F., Lu, Y., Chen, T., & Li, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.631972 · Cited by 485 · see citing works
Menstruation: science and society
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Role of the gut microbiota in type 2 diabetes and related diseases
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Towards a deeper understanding of the vaginal microbiota
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Network analysis methods for studying microbial communities: A mini review
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Endometrial microbiota composition is associated with reproductive outcome in infertile patients
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Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy
Serrano, M. G., Parikh, H. I., Brooks, J. P., Edwards, D. J., Arodz, T. J., Edupuganti, L., Huang, B., Girerd, P. H., Bokhari, Y. A., Bradley, S. P., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0465-8 · Cited by 300 · see citing works
Self-citationThe Role of Microbiota in Infant Health: From Early Life to Adulthood
Yao, Y., Cai, X. T., Ye, Y., Wang, F., Chen, F., & Zheng, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708472 · Cited by 264 · see citing works
Contribution of Lactobacillus iners to Vaginal Health and Diseases: A Systematic Review
Zheng, N., Guo, R., Wang, J., Zhou, W. M., & Ling, Z. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.792787 · Cited by 262 · see citing works
Problems with the concept of gut microbiota dysbiosis
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Bactopia: a Flexible Pipeline for Complete Analysis of Bacterial Genomes
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Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus
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The Interplay Between Reproductive Tract Microbiota and Immunological System in Human Reproduction
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Translocation of vaginal microbiota is involved in impairment and protection of uterine health
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Immune-microbe interactions early in life: A determinant of health and disease long term
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Microbial transmission, colonisation and succession: from pregnancy to infancy
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Infections and Pregnancy: Effects on Maternal and Child Health
Kumar, M., Saadaoui, M., & Khodor, S. A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.873253 · Cited by 173 · see citing works
The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis
Guðnadóttir, U., Debelius, J. W., Du, J., Hugerth, L. W., Danielsson, H., Schuppe‐Koistinen, I., Fransson, E., & Brusselaers, N. (2022) · Scientific Reports · doi:10.1038/s41598-022-12007-9 · Cited by 168 · see citing works
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The pregnancy microbiome and preterm birth
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Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions
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Kaur, H., Merchant, M., Haque, M. M., & Mande, S. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00551 · Cited by 155 · see citing works
Morrill, S. R., Gilbert, N. M., & Lewis, A. L. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00168 · Cited by 152 · see citing works
Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip
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Priorities for the next 10 years of human microbiome research
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Recent Insights on the Maternal Microbiota: Impact on Pregnancy Outcomes
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The Vaginal Microbiome in Health and Disease—What Role Do Common Intimate Hygiene Practices Play?
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Crosstalk between Vaginal Microbiome and Female Health: A review
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Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset
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A metagenomic strategy for harnessing the chemical repertoire of the human microbiome
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Single-cell approaches in human microbiome research
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Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span
Lehtoranta, L., Ala‐Jaakkola, R., Laitila, A., & Maukonen, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.819958 · Cited by 138 · see citing works
Batch effects removal for microbiome data via conditional quantile regression
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The impact of the female genital tract microbiome in women health and reproduction: a review
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The female reproductive tract microbiotas, inflammation, and gynecological conditions
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Roles of the Microbiota of the Female Reproductive Tract in Gynecological and Reproductive Health
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Self-citationDiversity of Vaginal Microbiome in Pregnancy: Deciphering the Obscurity
Gupta, P., Singh, M. P., & Goyal, K. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00326 · Cited by 119 · see citing works
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Immunobiology of Acute Chorioamnionitis
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The early life education of the immune system: Moms, microbes and (missed) opportunities
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Self-citationMale-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis
Vodstrcil, L. A., Plummer, E. L., Fairley, C. K., Hocking, J. S., Law, M. G., Petoumenos, K., Bateson, D. J., Murray, G. L., Donovan, B. J., Chow, E. P. F., et al. (2025) · New England Journal of Medicine · doi:10.1056/nejmoa2405404 · Cited by 113 · see citing works
Host and Microbiome Interplay Shapes the Vaginal Microenvironment
Kwon, M. S., & Lee, H. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.919728 · Cited by 112 · see citing works
Interactions between microbiota and cervical epithelial, immune, and mucus barrier
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The role of Lactobacillus species in the control of Candida via biotrophic interactions
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Prebiotic and Probiotic Modulation of the Microbiota–Gut–Brain Axis in Depression
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Understanding human health through metatranscriptomics
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Vaginal microbiota and human papillomavirus infection among young Swedish women
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Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response
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Maternal Infection and Preterm Birth: From Molecular Basis to Clinical Implications
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Assembly methods for nanopore-based metagenomic sequencing: a comparative study
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Vaginal Microbiome Signature Is Associated With Spontaneous Preterm Delivery
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Vaginal microecological characteristics of women in different physiological and pathological period
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Vaginal Microbiome in Preterm Rupture of Membranes
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Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation
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Preterm birth is associated with xenobiotics and predicted by the vaginal metabolome
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The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract
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Pregnancy immune tolerance at the maternal-fetal interface
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Microbiome epidemiology and association studies in human health
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The Interplay between Androgen and Gut Microbiota: Is There a Microbiota-Gut-Testis Axis
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Remodeling of the maternal gut microbiome during pregnancy is shaped by parity
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Self-citationJuliana, N. C. A., Suiters, M., Al‐Nasiry, S., Morré, S. A., Peters, R. P. H., & Ambrosino, E. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.567885 · Cited by 81 · see citing works
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Maternal Microbiome and Infections in Pregnancy
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Precocious puberty and microbiota: The role of the sex hormone–gut microbiome axis
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Vaginal Microbiota and Cytokine Levels Predict Preterm Delivery in Asian Women
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Next generation strategies for preventing preterm birth
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Metagenomics and artificial intelligence in the context of human health
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Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator
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- Authors
- Fettweis, J. M., Serrano, M. G., Brooks, J. P., Edwards, D. J., Girerd, P. H., Parikh, H. I., Huang, B., Arodz, T. J., Edupuganti, L., Glascock, A. L., Xu, J., Jimenez, N. R., Vivadelli, S. C., Fong, S. S., Sheth, N. U., Jean, S., Lee, V., Bokhari, Y. A., Lara, A. M., Mistry, S. D., Duckworth, R. A., Bradley, S. P., Koparde, V. N., Orenda, X. V., Milton, S. H., Rozycki, S. K., Matveyev, A. V., Wright, M. L., Huzurbazar, S. V., Jackson, E. M., Smirnova, E., Korlach, J., Tsai, Y.-C., Dickinson, M. R., Brooks, J. L., Drake, J. I., Chaffin, D. O., Sexton, A. L., Gravett, M. G., Rubens, C. E., Wijesooriya, N. R., Hendricks-Muñoz, K. D., Jefferson, K. K., Strauss, J. F., & Buck, G. A.
- Affiliations
- Virginia Commonwealth University (US)
- Emory University (US)
- West Virginia University (US)
- Pacific Biosciences (United States) (US)
- Global Alliance to Prevent Prematurity and Stillbirth (US)
- University of Washington (US)
- Corresponding author
- Buck, Gregory A.
- ORCID
- Fettweis, Jennifer M.
- Serrano, Myrna G.
- Brooks, J. Paul
- Edwards, David J.
- Parikh, Hardik I.
- Arodz, Tom J.
- Edupuganti, Laahirie
- Glascock, Abigail L.
- Xu, Jie
- Jimenez, Nicole R.
- Fong, Stephen S.
- Bokhari, Yahya A.
- Orenda, X. Valentine
- Rozycki, Sarah K.
- Wright, Michelle L.
- Huzurbazar, Snehalata V.
- Smirnova, Ekaterina
- Korlach, Jonas
- Tsai, Yu-Chih
- Brooks, Jamie L.
- Drake, Jennifer I.
- Gravett, Michael G.
- Jefferson, Kimberly K.
- Strauss, Jerome F.
- Buck, Gregory A.
- Venue
- Nature Medicine
- Published
- 2019-05-29
- Volume
- 25
- Issue
- 6
- Pages
- 1012-1021
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC6750801
- OpenAlex
- W2947640277
- Cited by
- 983
- References
- 83
- Citations by year
- 2026: 116 · 2025: 138 · 2024: 124 · 2023: 147 · 2022: 149 · 2021: 165 · 2020: 115 · 2019: 28
- FWCI
- 84.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Nature Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1453658)
- Bill and Melinda Gates Foundation
- National Institutes of Health
- National Institute of General Medical Sciences (R25GM089614, R25GM090084)
- National Institute of Allergy and Infectious Diseases (UH2AI083263, UH3AI083263)
- National Institute of Dental and Craniofacial Research (U54DE023786)
- Office of Research on Women's Health
- National Center for Complementary and Integrative Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD080784, R01HD092415, R21HD092965)
- Common Fund
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- vaginal microbiota, preterm birth, African ancestry, Lactobacillus crispatus, Sneathia amnii, Prevotella, inflammatory cytokines, vaginal secretions, preterm birth prediction, Human Microbiome Project, metagenomics, metatranscriptomics, 16S rRNA
- MeSH terms
- Host Microbial Interactions, Adult, Black or African American, Female, Humans, Infant, Newborn, Longitudinal Studies, Risk Factors, United States, Vagina, Cohort Studies, Cytokines, Inflammation Mediators, Biodiversity, Premature Birth, Young Adult, Metagenomics, Microbiota
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