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Treatment of opioid-dependent pregnant women: Clinical and research issues
Open accessAbstract
This article addresses common questions that clinicians face when treating pregnant women with opioid dependence. Guidance, based on both research evidence and the collective clinical experience of the authors, which include investigators in the Maternal Opioid Treatment: Human Experimental Research (MOTHER) project, is provided to aid clinical decision making. The MOTHER project is a double-blind, double-dummy, flexible-dosing, parallel-group clinical trial examining the comparative safety and efficacy of methadone and buprenorphine for the treatment of opioid dependence in pregnant women and their neonates. The article begins with a discussion of appropriate assessment during pregnancy and then addresses clinical management stages including maintenance medication selection, induction, and stabilization; opioid agonist medication management before, during, and after delivery; pain management; breast-feeding; and transfer to aftercare. Lastly, other important clinical issues including managing co-occurring psychiatric disorders and medication interactions are discussed.
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“Current standard of care for treatment of OUD is medication treatment, most often with methadone or buprenorphine [1].”
From Mindful moms: acceptability and impact of co-designed and digitally delivered video meditations for pregnant and parenting women with opioid use disorder (2025) · cites this paper as [1]
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Metadata
- Authors
- Jones, H. E., Martin, P. R., Heil, S. H., Kaltenbach, K., Selby, P., Coyle, M. G., Stine, S. M., O'Grady, K. E., Arria, A. M., & Fischer, G.
- Affiliations
- Vanderbilt University (US)
- University of Vermont (US)
- Thomas Jefferson University (US)
- University of Toronto (CA)
- Brown University (US)
- Wayne State University (US)
- University of Maryland, College Park (US)
- Medical University of Vienna (AT)
- ORCID
- Venue
- Journal of Substance Abuse Treatment
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 35
- Issue
- 3
- Pages
- 245-259
- ISSN
- 0740-5472 (ISSN-L)
- PMC
- PMC2633026
- OpenAlex
- W2094830932
- Cited by
- 191
- References
- 137
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 12 · 2019: 16 · 2018: 16 · 2017: 10 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 8 · 2012: 16
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Substance Abuse Treatment (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Rice University
- University of Vermont
- Universität Wien
- National Institute on Drug Abuse (R01 DA15832, R01DA015778, R01DA015764, R01DA 0184103, R01DA015713, R01DA 0175138, R01DA015832, R01DA015741, R01DA015738, R01DA018410, R01DA018417)
- National Center for Research Resources (M01RR000095, M01RR000109, M01-RR-00095)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- opioid use disorder, pregnancy, maternal opioid treatment, methadone, buprenorphine, neonatal outcomes, induction, stabilization, pain management, breastfeeding, follow-up care, psychiatric comorbidity, drug interactions, clinical decision-making
- MeSH terms
- Analgesics, Opioid, Buprenorphine, Clinical Trials as Topic, Decision Making, Female, Humans, Infant, Newborn, Methadone, Opioid-Related Disorders, Pain, Pregnancy, Pregnancy Complications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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