Cited by 191Opioid Use Disorder TreatmentPrenatal Substance Exposure EffectsPregnancy and Medication Impact

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Treatment of opioid-dependent pregnant women: Clinical and research issues

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Jones, Hendree E., Martin, Peter R., Heil, Sarah H., Kaltenbach, Karol, Selby, Peter, Coyle, Mara G., Stine, Susan M., O'Grady, Kevin E., Arria, Amelia M., Fischer, Gabriele·2008·Journal of Substance Abuse Treatment

DOI 10.1016/j.jsat.2007.10.007PMC PMC2633026

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Abstract

This article addresses common questions that clinicians face when treating pregnant women with opioid dependence. Guidance, based on both research evidence and the collective clinical experience of the authors, which include investigators in the Maternal Opioid Treatment: Human Experimental Research (MOTHER) project, is provided to aid clinical decision making. The MOTHER project is a double-blind, double-dummy, flexible-dosing, parallel-group clinical trial examining the comparative safety and efficacy of methadone and buprenorphine for the treatment of opioid dependence in pregnant women and their neonates. The article begins with a discussion of appropriate assessment during pregnancy and then addresses clinical management stages including maintenance medication selection, induction, and stabilization; opioid agonist medication management before, during, and after delivery; pain management; breast-feeding; and transfer to aftercare. Lastly, other important clinical issues including managing co-occurring psychiatric disorders and medication interactions are discussed.

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See all 191

Authors: Jones, H. E., Martin, P. R., Heil, S. H., Kaltenbach, K., Selby, P., Coyle, M. G., Stine, S. M., O'Grady, K. E., Arria, A. M., & Fischer, G.
Affiliations: Vanderbilt University (US)
University of Vermont (US)
Thomas Jefferson University (US)
University of Toronto (CA)
Brown University (US)
Wayne State University (US)
University of Maryland, College Park (US)
Medical University of Vienna (AT)
ORCID: Martin, Peter R.
Heil, Sarah H.
Selby, Peter
Coyle, Mara G.
Stine, Susan M.
Arria, Amelia M.
Fischer, Gabriele
Venue: Journal of Substance Abuse Treatment
Publisher: Elsevier BV
Published: 2008-10
Volume: 35
Issue: 3
Pages: 245-259
ISSN: 0740-5472 (ISSN-L)
DOI: 10.1016/j.jsat.2007.10.007
PMC: PMC2633026
OpenAlex: W2094830932
Cited by: 191
References: 137
Citations by year: 2026: 4 · 2025: 9 · 2024: 10 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 12 · 2019: 16 · 2018: 16 · 2017: 10 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 8 · 2012: 16
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Substance Abuse Treatment (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Rice University
University of Vermont
Universität Wien
National Institute on Drug Abuse (R01 DA15832, R01DA015778, R01DA015764, R01DA 0184103, R01DA015713, R01DA 0175138, R01DA015832, R01DA015741, R01DA015738, R01DA018410, R01DA018417)
National Center for Research Resources (M01RR000095, M01RR000109, M01-RR-00095)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords: opioid use disorder, pregnancy, maternal opioid treatment, methadone, buprenorphine, neonatal outcomes, induction, stabilization, pain management, breastfeeding, follow-up care, psychiatric comorbidity, drug interactions, clinical decision-making
MeSH terms: Analgesics, Opioid, Buprenorphine, Clinical Trials as Topic, Decision Making, Female, Humans, Infant, Newborn, Methadone, Opioid-Related Disorders, Pain, Pregnancy, Pregnancy Complications

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