Buprenorphine treatment of pregnant opioid-dependent women: maternal and neonatal outcomes
Abstract
This open-label prospective study examined maternal and neonatal safety and efficacy outcome measures during and following prenatal buprenorphine exposure. Three opioid-dependent pregnant women received 8 or 12 mg sublingual buprenorphine tablets daily for 15-16 weeks prior to delivery. Results showed that buprenorphine in combination with comprehensive prenatal care was safe and effective in these women. Prenatal exposure to buprenorphine resulted in normal birth outcomes, a mean of 4.33 days (minimum possible=4) hospitalization, and a 'relatively mild' neonatal abstinence syndrome comprised primarily of tremors (disturbed), hyperactive moro and shortened sleep after feeding. The infants required no pharmacological treatment. Onset of neonatal abstinence signs occurred within the first 12 h after birth, peaked by 72 h and returned to below pre-12 h levels by 120 h. It is concluded that buprenorphine has potential utility for the treatment of pregnant opioid-dependent women.
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The NNNS is sensitive to effects of intrauterine drug exposure but also captures the normative range of behaviors.
“The exam is sensitive to effects of intrauterine drug exposure22, 23 but also captures the normative range of behaviors.”
From Maternal Smoking during Pregnancy and Newborn Neurobehavior: Effects at 10 to 27 Days (2009) · cites this paper as [23]
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- Authors
- Johnson, R. E., Jones, H. E., Jasinski, D. R., Svikis, D. S., Haug, N. A., Jansson, L. M., Kissin, W. B., Alpan, G., Lantz, M. E., Cone, E. J., Wilkins, D. G., Golden, A. S., Huggins, G. R., & Lester, B. M.
- Affiliations
- Johns Hopkins University (US)
- National Institute on Drug Abuse (US)
- University of Utah (US)
- Brown University (US)
- Corresponding author
- Jones, Hendrée E
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 63
- Issue
- 1
- Pages
- 97-103
- ISSN
- 0376-8716 (ISSN-L)
- OpenAlex
- W2162092714
- Cited by
- 125
- References
- 21
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 11 · 2012: 9
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- U.S. Public Health Service
- National Institute on Drug Abuse (DA 09258, DA 07029, 2P50-DA05273-11, R01DA007029, P50DA009258, P50DA005273)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- buprenorphine, opioid use disorder, pregnancy, neonatal abstinence syndrome, maternal outcomes, neonatal outcomes, sublingual buprenorphine, prenatal care, neonatal hospitalization
- MeSH terms
- Adult, Buprenorphine, Female, Health Status, Humans, Infant, Narcotic Antagonists, Opioid-Related Disorders, Pregnancy, Pregnancy Complications, Pregnancy Outcome
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