The DOI matches its Crossref record; 35 of the 37 references it cites were found in a registry or an index.
Aromatase in endometriosis and uterine leiomyomata
Abstract
Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis. PGE2 stimulates both aromatase expression and activity in endometriotic stromal cells via promoter II region of the aromatase gene. This results in local production of estradiol, which induces PGE2 formation and establishes a positive feedback cycle. This mechanism seems to contribute to continuous production of estradiol and PGE2. Aromatase mRNA levels and enzyme activity are also present in uterine leiomyomata that are estrogen-dependent benign tumors of the myometrium. Successful treatment of endometriosis and uterine leiomyomata using aromatase inhibitors by recent pilot trials underscores the clinical significance of these molecular studies.
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“The oestrogen can be further produced in the endometrial lesions by aromatase activity [14].”
From 5-Year data analysis of patients following abdominal wall endometrioma surgery (2014) · cites this paper as [14]
Citations
Cites
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334
Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis*
SIMPSON, E. R., Mahendroo, M., Means, G., Kilgore, M. W., Hinshelwood, M. M., Graham-Lorence, S. E., Amarneh, B., Ito, Y., Fisher, C. R., Michael, M. D., et al. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-3-342 · Cited by 1,542
Self-citationOlive, D. L., & Schwartz, L. B. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306173282407 · Cited by 675
Aromatase expression in endometriosis.
Noble, L. S., Simpson, E. R., Johns, A., & Bulun, S. E. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.1.8550748 · Cited by 566
Self-citationAromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis
Simpson, E. R. (1994) · Endocrine Reviews · doi:10.1210/er.15.3.342 · Cited by 482
MacDonald, P. C., Edman, C. D., Hemsell, D. L., Porter, J. C., & Siiteri, P. K. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90287-9 · Cited by 440
Aromatization of Androstenedione by Human Adipose Tissue Stromal Cells in Monolayer Culture*
Ackerman, G. E., Smith, M. E., Mendelson, C. R., MacDonald, P. C., & Simpson, E. R. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-2-412 · Cited by 389
Bulun, S. E., Price, T. M., Aitken, R. J., Mahendroo, M., & Simpson, E. R. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8117355 · Cited by 334
Self-citationZeitoun, K., Takayama, K., Sasano, H., Suzuki, T., Moghrabi, N., Andersson, S., Johns, A., Meng, L., Putman, M., Carr, B., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5301 · Cited by 308
Self-citationProstaglandin E2 Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells
Noble, L. S. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.2.600 · Cited by 301
Self-citation
Research works printed but not linked: 1
- Bulun, 1994, Expression of the CYP19 gene and its product aromatase cytochrome P450 in human leiomyoma tissues and cells in culture, J. Clin. Endocrinol. Metab., 78, 736
Cited by
Sorted by citations
Endometriosis is a chronic systemic disease: Clinical challenges and novel innovations
Taylor, H. S., Kotlyar, A. M., & Flores, V. A. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00389-5 · Cited by 1,425
Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment
Yang, Q., Ciebiera, M., Bariani, M. V., Ali, M. K., Elkafas, H., Boyer, T., & Al-Hendy, A. A. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab039 · Cited by 497
“Adrenal androgens are mostly metabolized by aromatase in adipose tissues to estrogens (67-69).”
BackgroundFibroids and female reproduction: a critical analysis of the evidence
Somigliana, E., Vercellini, P., Daguati, R., Pasin, R., Giorgi, O. D., & Crosignani, P. G. (2007) · Human Reproduction Update · doi:10.1093/humupd/dmm013 · Cited by 350
Epidemiology of Uterine Fibroids
Wise, L. A., & Laughlin-Tommaso, S. K. (2016) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000164 · Cited by 367
“In both prospective and case-control studies, the risk of surgically confirmedULwas increased up to 6fold inwomenusing estrogenor combined estrogen-progestin therapy compared with nonusers.(46,48,82,150) Diethylstilbestrol (DES): Prenatal exposure toDES has been shown to cause longterm changes in estrogen-related gene…”
BackgroundEstrogen receptors and human disease: an update
Burns, K. A., & Korach, K. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0868-5 · Cited by 287
Metadata
- Authors
- Bulun, S. E., Imir, G., Utsunomiya, H., Thung, S., Gurates, B., Tamura, M., & Lin, Z.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Bulun, Serdar E.
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 95
- Issue
- 1-5
- Pages
- 57-62
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2119512564
- Cited by
- 154
- References
- 37
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 11 · 2013: 3 · 2012: 11
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD046260, HD-38691, HD46260)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- aromatase, endometriosis, uterine fibroids, prostaglandin E2, endometrial stromal cells, estradiol production, positive feedback loop, aromatase inhibitors, estrogen-dependent tumors
- MeSH terms
- Aromatase, Endometriosis, Estrogens, Female, Humans, Leiomyoma, Uterine Neoplasms, Uterus, Aromatase Inhibitors
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